Q8P475

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
KEGG Pathway
xcc:XCC3841
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

292-391 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8P475

Entry ID Method Resolution Chain Position Source
AF-Q8P475-F1 Predicted AlphaFoldDB

No variants for Q8P475

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8P475

No associated diseases with Q8P475

2 regional properties for Q8P475

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 39 - 49 IPR001412
domain RNA-binding S4 domain 352 - 414 IPR002942

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

2 GO annotations of biological process

Name Definition
tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATIDESLAL IGRGAEEILK LEQLEARLTS GVPLRVKAGF DPTAPDLHLG HTVLLNKMRQ
70 80 90 100 110 120
FQELGHQVIF LIGDFTGMIG DPSGKNVTRK PLSREDVLAN ARTYEEQVFK ILDRTRTEVR
130 140 150 160 170 180
FNSEWFGQMS AADMIKLSAQ HTVARMLERD DFAKRFAGQQ PIAIHEFLYP LVQGYDSVAL
190 200 210 220 230 240
KADVELGGTD QTFNLLMGRG LQEHYGQAPQ VVLTMPLLEG LDGVAKMSKS LGNYIGINEP
250 260 270 280 290 300
AIDIVTKTMK IGDTLTWRWI DLLSFDISVA EAARFKEDVA AGNLHPRDVK LRLARELATR
310 320 330 340 350 360
FHDAATAEQA IAGWHAVVTG QGDTSVLPLQ QVSVPAEGLR IASLLTAAGL TPSNSEATRK
370 380 390 400
LKERAVKIDG EVVDDLARQF GPGFEGVIQV GKRNFARVAL VTS