Q8NZB4

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Streptococcus pyogenes serotype M18 (strain MGAS8232)
KEGG Pathway
spm:spyM18_2030
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

236-317 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NZB4

Entry ID Method Resolution Chain Position Source
AF-Q8NZB4-F1 Predicted AlphaFoldDB

No variants for Q8NZB4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NZB4

No associated diseases with Q8NZB4

3 regional properties for Q8NZB4

Type Name Position InterPro Accession
domain Protein kinase domain 40 - 335 IPR000719
active_site Serine/threonine-protein kinase, active site 159 - 171 IPR008271
binding_site Protein kinase, ATP binding site 46 - 68 IPR017441

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQSKLLIPT LREMPSDAQV ISHALMVRAG YVRQVSAGIY AYLPLANRTI EKFKTIMREE
70 80 90 100 110 120
FEKIGAVEML APALLTADLW RESGRYETYG EDLYKLKNRD NSDFILGPTH EETFTTLVRN
130 140 150 160 170 180
AVKSYKQLPL NLYQIQSKYR DEKRPRNGLL RTREFIMKDG YSFHHNYEDL DVTYEDYRQA
190 200 210 220 230 240
YEAIFTRAGL DFKGIIGDGG AMGGKDSQEF MAITPARTDL DRWVVLDKSI ASMDDIPKEV
250 260 270 280 290 300
LEEIKAELAA WMISGEDTIA YSTESSYAAN LEMATNEYKP SSKVAAEDAL VEVETPHCKT
310 320 330 340 350 360
IDEVAAFLSV DETQTIKTLL FVADNEPVVA LLVGNDHINT VKLKNYLAAD FLEPASEEEA
370 380 390 400 410 420
RAFFGAGFGS LGPVNLAQGS RIVADRKVQN LTNAVAGANK DGFHVTGVNP GRDFQAEYVD
430 440 450 460 470 480
IREVKEGEMS PDGHGVLQFA RGIEVGHIFK LGTRYSDSMG ATILDENGRA VPIVMGCYGI
490 500 510 520 530 540
GVSRILSAVI EQHARLFVNK TPKGDYRYAW GINFPKELAP FDVHLITVNV KDQVAQDLTA
550 560 570 580 590 600
KLEADLMAKG YDVLTDDRNE RVGSKFSDSD LIGLPIRVTV GKKAAEGIVE IKIKATGDSI
610
EVNAENLIET LEILTKEH