Q8NTY7

PR
Gene name
iolG
Protein name
Inositol 2-dehydrogenase
Names
Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl0164
EC number
1.1.1.18: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-135 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NTY7

Entry ID Method Resolution Chain Position Source
AF-Q8NTY7-F1 Predicted AlphaFoldDB

No variants for Q8NTY7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NTY7

No associated diseases with Q8NTY7

2 regional properties for Q8NTY7

Type Name Position InterPro Accession
domain Gfo/Idh/MocA-like oxidoreductase, N-terminal 5 - 125 IPR000683
domain Gfo/Idh/MocA-like oxidoreductase, C-terminal 138 - 323 IPR004104

Functions

Description
EC Number 1.1.1.18 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
inositol 2-dehydrogenase activity Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKSLRVGVV GAGAMGADHI DRINNRTSGA HISAIIEPDA ARAAAAAEDA PGAQAFTRIE
70 80 90 100 110 120
DAIAADAVDA VLIAVPGQFH EPVLVPALEA GLPILCEKPL TPDSESSLRI VELEQKLDKP
130 140 150 160 170 180
HIQVGFMRRF DPEYNNLRKL VESGEAGELL MLRGLHRNPS VGESYTQSML ITDSVVHEFD
190 200 210 220 230 240
VIPWLAGSRV VSVEVKYPKT SSLAHSGLKE PILVIMELEN GVLVDVEMNV NIQFGYQVAT
250 260 270 280 290 300
EAVFEKGLAR IGQPSGMQRW RDGEFLINEH TDFTTRFATA YDRQIQSWVD AVHEGTLVAG
310 320 330
PNAWDGYLVA LSCEAGVKAL DGGVIPVDAA PRPDFYA