Q8NSL3

PR
Gene name
prpD2 (Cgl0657, cg0759)
Protein name
2-methylcitrate dehydratase 2
Names
2-MC dehydratase, Aconitate hydratase, ACN, Aconitase
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl0657
EC number
4.2.1.3: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

264-334 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NSL3

Entry ID Method Resolution Chain Position Source
AF-Q8NSL3-F1 Predicted AlphaFoldDB

No variants for Q8NSL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NSL3

No associated diseases with Q8NSL3

No regional properties for Q8NSL3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8NSL3

Functions

Description
EC Number 4.2.1.3 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
2-methylcitrate dehydratase activity Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O.
aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O.

2 GO annotations of biological process

Name Definition
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MINHEVRTHR SAEEFPYEEH LAHKIARVAA DPVEVAADTQ EMIINRIIDN ASVQAASVLR
70 80 90 100 110 120
RPVSSARAMA QVRPVTDGRG ASVFGLPGRY AAEWAALANG TAVRELDFHD TFLAAEYSHP
130 140 150 160 170 180
GDNIPPILAA AQQAGKGGKD LIRGIATGYE IQVNLVRGMC LHEHKIDHVA HLGPSAAAGI
190 200 210 220 230 240
GTLLDLDVDT IYQAIGQALH TTTATRQSRK GAISSWKAFA PAFAGKMSIE AVDRAMRGEG
250 260 270 280 290 300
APSPIWEGED GVIAWLLSGL DHIYTIPLPA EGEAKRAILD TYTKEHSAEY QSQAPIDLAR
310 320 330 340 350 360
SMGEKLAAQG LDLRDVDSIV LHTSHHTHYV IGTGSNDPQK FDPDASRETL DHSIMYIFAV
370 380 390 400 410 420
ALEDRAWHHE RSYAPERAHR RETIELWNKI STVEDPEWTR RYHSVDPAEK AFGARAVITF
430 440 450 460 470 480
KDGTVVEDEL AVADAHPLGA RPFAREQYIQ KFRTLAEGVV SEKEQDRFLD AAQRTHELED
490 500
LSELNIELDA DILAKAPVIP EGLF