Q8NSL2

PR
Gene name
prpB2
Protein name
Probable 2-methylisocitrate lyase 2
Names
2-MIC, MICL, (2R,3S)-2-methylisocitrate lyase
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl0658
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NSL2

Entry ID Method Resolution Chain Position Source
AF-Q8NSL2-F1 Predicted AlphaFoldDB

No variants for Q8NSL2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NSL2

No associated diseases with Q8NSL2

2 regional properties for Q8NSL2

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 127 - 132 IPR018523
domain ICL/PEPM domain 25 - 259 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGLFSSAVA PTERRKALRA ALAAPEIARM PGAFSPLAAR AIQEAGFEGV YVSGAVVAAD
70 80 90 100 110 120
LALPDIGLTT LTEVAHRSRQ IARVTDLPVL VDADTGFGEP MSAARTVSEL EDAGVAGCHL
130 140 150 160 170 180
EDQVNPKRCG HLDGKEVVGT DIMVRRIAAA VNERRDEQFV ICARTDAAGV EGIDSAIERA
190 200 210 220 230 240
KAYADAGADM IFTEALYSPA DFEKFRAAVD IPLLANMTEF GKTELLPAQL LEDIGYNAVI
250 260 270 280 290 300
YPVTLLRIAM GQVEQALGDI ANTGIQTDWV DRMQHRSRLY ELLRYNEYNA FDQQVFTYSA
DSYKPIF