Q8NRB3

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl1139
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

339-463 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NRB3

Entry ID Method Resolution Chain Position Source
AF-Q8NRB3-F1 Predicted AlphaFoldDB

No variants for Q8NRB3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NRB3

No associated diseases with Q8NRB3

2 regional properties for Q8NRB3

Type Name Position InterPro Accession
domain Cobalamin-independent methionine synthase MetE, C-terminal/archaeal 413 - 735 IPR002629
domain Cobalamin-independent methionine synthase MetE, N-terminal 7 - 308 IPR013215

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSNFSSTVA GLPRIGAKRE LKFALEGYWN GSIEGRELAQ TARQLVNTAS DSLSGLDSVP
70 80 90 100 110 120
FAGRSYYDAM LDTAAILGVL PERFDDIADH ENDGLPLWID RYFGAARGTE TLPAQAMTKW
130 140 150 160 170 180
FDTNYHYLVP ELSADTRFVL DASALIEDLR CQQVRGVNAR PVLVGPLTFL SLARTTDGSN
190 200 210 220 230 240
PLDHLPALFE VYERLIKSFD TEWVQIDEPA LVTDVAPEVL EQVRAGYTTL AKRDGVFVNT
250 260 270 280 290 300
YFGSGDQALN TLAGIGLGAI GVDLVTHGVT ELAAWKGEEL LVAGIVDGRN IWRTDLCAAL
310 320 330 340 350 360
ASLKRLAARG PIAVSTSCSL LHVPYTLEAE NIEPEVRDWL AFGSEKITEV KLLADALAGN
370 380 390 400 410 420
IDAAAFDAAS AAIASRRTSP RTAPITQELP GRSRGSFDTR VTLQEKSLEL PALPTTTIGS
430 440 450 460 470 480
FPQTPSIRSA RARLRKESIT LEQYEEAMRE EIDLVIAKQE ELGLDVLVHG EPERNDMVQY
490 500 510 520 530 540
FSELLDGFLS TANGWVQSYG SRCVRPPVLF GNVSRPAPMT VKWFQYAQSL TQKHVKGMLT
550 560 570 580 590 600
GPVTILAWSF VRDDQPLATT ADQVALALRD EINDLIEAGA KIIQVDEPAI RELLPLRDVD
610 620 630 640 650 660
KPAYLQWSVD SFRLATAGAP DDVQIHTHMC YSEFNEVISS VIALDADVTT IEAARSDMQV
670 680 690 700 710 720
LAALKSSGFE LGVGPGVWDI HSPRVPSAQE VDGLLEAALQ SVDPRQLWVN PDCGLKTRGW
730 740
PEVEASLKVL VESAKQAREK IGATI