Q8NQU9

PR
Gene name
ung (Cgl1324, cg1496)
Protein name
Uracil-DNA glycosylase
Names
UDG
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl1324
EC number
3.2.2.27: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NQU9

Entry ID Method Resolution Chain Position Source
AF-Q8NQU9-F1 Predicted AlphaFoldDB

No variants for Q8NQU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NQU9

No associated diseases with Q8NQU9

2 regional properties for Q8NQU9

Type Name Position InterPro Accession
domain Uracil-DNA glycosylase-like 57 - 242 IPR005122
active_site Uracil-DNA glycosylase, active site 65 - 74 IPR018085

Functions

Description
EC Number 3.2.2.27 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKLLMTNTL WNSVDELPIH DSWKPVLKPV EDAIRKLGVF LAEEEFLPPV DDVFRAFSYP
70 80 90 100 110 120
FDAVKVLIMG QDPYPTPGHA MGLSFSTQPD VRPLPRSLNN IFKELVSDVG SLGDSASEQG
130 140 150 160 170 180
ALDLGINAPG SVAGTQVALP ADGDLRAWSN QGVALFNRVL TVHPGQAGSH KGKGWEAVTE
190 200 210 220 230 240
QAIKALAERD QPLVAILWGK QAQEVQKFLG DTPCICSVHP SPLSASRGFF GSKPFSRANE
250
ILSSLGATEI DWSL