Q8NQM8

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl1406
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

193-412 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NQM8

Entry ID Method Resolution Chain Position Source
AF-Q8NQM8-F1 Predicted AlphaFoldDB

No variants for Q8NQM8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NQM8

No associated diseases with Q8NQM8

3 regional properties for Q8NQM8

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 217 - 318 IPR005123
domain Non-haem dioxygenase N-terminal domain 64 - 170 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 221 - 316 IPR044861

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNIIDELSWR GLINQSTDLE ALREEASTPI TLYCGFDPTG PSLHAGHLVP LLMLRRFQQA
70 80 90 100 110 120
GHNPIVLAGG ATGMIGDPRD VGERTMNSAD TVSDWAERIS GQLSRFVDFD GEHAARLVNN
130 140 150 160 170 180
AEWTNEMSVV TFLRDVGKHF SLNTMLARDT VKRRLESDGI SYTEFSYMLL QANDYVELNK
190 200 210 220 230 240
RFGCTLQVGG GDQWGNIVSG VDLNRRVNGT SVHAVTVPLV TDSDGKKFGK STGGGSLWLD
250 260 270 280 290 300
PEMTSPYAWY QYFINASDAD VIRYLRWFTF LTQEELAELE VEVAERPFKR EAQRRLAREM
310 320 330 340 350 360
TNLVHGTEAT EAVELAAQAL FGRAELRDLD EKTLAASVSE TAVAEIKAGE PRTIIDLLVA
370 380 390 400 410
SGLADSKGAA KRAVKEGGAY VNNERIESDD WEPFAEDLLH GSWLVLRRGK KNFAGVQILG