Q8NQJ3
Gene name |
odhI |
Protein name |
Oxoglutarate dehydrogenase inhibitor |
Names |
|
Species |
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) |
KEGG Pathway |
cgl:NCgl1385 |
EC number |
|
Protein Class |
NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 (PTHR23308) |
Descriptions
The Odhl protein is a Krebs cycle key regulator in C. glutamicum. The unphosphorylated form of OdhI inhibits the fourth step of the cycle, and the phosphorylated form is inactive. The unstructured N-terminal segment of Odhl undergoes considerable conformational changes upon phosphorylation by CgPknA or CgPknB. These changes comprise a switch of the N-terminal part of the protein in close vicinity to the FHA domain phosphopeptide binding site, leading to a fully inactive protein unable to bind to OdhA.
Autoinhibitory domains (AIDs)
Target domain |
67-131 (FHA domain) |
Relief mechanism |
PTM |
Assay |
Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q8NQJ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KB3 | NMR | - | A | 1-143 | PDB |
| 2KB4 | NMR | - | A | 1-143 | PDB |
| 4QCJ | X-ray | 200 A | A | 1-143 | PDB |
| 8P5X | EM | 229 A | G/H/I/J/K/L | 1-143 | PDB |
| AF-Q8NQJ3-F1 | Predicted | AlphaFoldDB |
No variants for Q8NQJ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8NQJ3 | |||||
No associated diseases with Q8NQJ3
8 regional properties for Q8NQJ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 316 - 351 | IPR002048 |
| domain | GTP binding domain | 430 - 522 | IPR006073 |
| domain | Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 | 353 - 421 | IPR013566 |
| domain | EF hand associated, type-2 | 230 - 315 | IPR013567 |
| binding_site | EF-Hand 1, calcium-binding site | 208 - 220 | IPR018247-1 |
| binding_site | EF-Hand 1, calcium-binding site | 329 - 341 | IPR018247-2 |
| domain | MIRO domain | 12 - 179 | IPR020860-1 |
| domain | MIRO domain | 425 - 599 | IPR020860-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR23308 | NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 |
| PANTHER Subfamily | PTHR23308:SF72 | GLYCOGEN ACCUMULATION REGULATOR GARA |
| PANTHER Protein Class |
RNA splicing factor
RNA metabolism protein RNA processing factor |
|
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDNNGTPEP | QVETTSVFRA | DLLKEMESST | GTAPASTGAE | NLPAGSALLV | VKRGPNAGAR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLLDQPTTTA | GRHPESDIFL | DDVTVSRRHA | EFRINEGEFE | VVDVGSLNGT | YVNREPRNAQ |
| 130 | 140 | ||||
| VMQTGDEIQI | GKFRLVFLAG | PAE |