Q8NNK8

PR
Gene name
pimB
Protein name
GDP-mannose-dependent monoacylated alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase
Names
Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase, Alpha-mannosyltransferase, Alpha-ManT, Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase, Phosphatidylinositol alpha-mannosyltransferase, PI alpha-mannosyltransferase
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl2186
EC number
2.4.1.346: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

146-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q8NNK8

Entry ID Method Resolution Chain Position Source
3OKA X-ray 220 A A/B 1-381 PDB
3OKC X-ray 240 A A 1-381 PDB
3OKP X-ray 200 A A 1-381 PDB
AF-Q8NNK8-F1 Predicted AlphaFoldDB

No variants for Q8NNK8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NNK8

No associated diseases with Q8NNK8

2 regional properties for Q8NNK8

Type Name Position InterPro Accession
domain Glycosyl transferase, family 1 185 - 357 IPR001296
domain Glycosyltransferase subfamily 4-like, N-terminal domain 18 - 176 IPR028098

Functions

Description
EC Number 2.4.1.346 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glycolipid 1,6-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.
phosphatidylinositol alpha-mannosyltransferase activity Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol.

3 GO annotations of biological process

Name Definition
glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSASRKTLVV TNDFPPRIGG IQSYLRDFIA TQDPESIVVF ASTQNAEEAH AYDKTLDYEV
70 80 90 100 110 120
IRWPRSVMLP TPTTAHAMAE IIREREIDNV WFGAAAPLAL MAGTAKQAGA SKVIASTHGH
130 140 150 160 170 180
EVGWSMLPGS RQSLRKIGTE VDVLTYISQY TLRRFKSAFG SHPTFEHLPS GVDVKRFTPA
190 200 210 220 230 240
TPEDKSATRK KLGFTDTTPV IACNSRLVPR KGQDSLIKAM PQVIAARPDA QLLIVGSGRY
250 260 270 280 290 300
ESTLRRLATD VSQNVKFLGR LEYQDMINTL AAADIFAMPA RTRGGGLDVE GLGIVYLEAQ
310 320 330 340 350 360
ACGVPVIAGT SGGAPETVTP ATGLVVEGSD VDKLSELLIE LLDDPIRRAA MGAAGRAHVE
370 380
AEWSWEIMGE RLTNILQSEP R