Q8NNF6

PR
Gene name
aceE (Cgl2248, cg2466)
Protein name
Pyruvate dehydrogenase E1 component
Names
E1p, PDH E1 component
Species
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
KEGG Pathway
cgl:Cgl2248
EC number
1.2.4.1: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NNF6

Entry ID Method Resolution Chain Position Source
AF-Q8NNF6-F1 Predicted AlphaFoldDB

No variants for Q8NNF6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NNF6

No associated diseases with Q8NNF6

2 regional properties for Q8NNF6

Type Name Position InterPro Accession
domain Peptide chain release factor class I 214 - 321 IPR000352
domain Peptide chain release factor 12 - 203 IPR005139

Functions

Description
EC Number 1.2.4.1 With a disulfide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.

1 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADQAKLGGK PSDDSNFAMI RDGVASYLND SDPEETNEWM DSLDGLLQES SPERARYLML
70 80 90 100 110 120
RLLERASAKR VSLPPMTSTD YVNTIPTSME PEFPGDEEME KRYRRWIRWN AAIMVHRAQR
130 140 150 160 170 180
PGIGVGGHIS TYAGAAPLYE VGFNHFFRGK DHPGGGDQIF FQGHASPGMY ARAFMEGRLS
190 200 210 220 230 240
EDDLDGFRQE VSREQGGIPS YPHPHGMKDF WEFPTVSMGL GPMDAIYQAR FNRYLENRGI
250 260 270 280 290 300
KDTSDQHVWA FLGDGEMDEP ESRGLIQQAA LNNLDNLTFV VNCNLQRLDG PVRGNTKIIQ
310 320 330 340 350 360
ELESFFRGAG WSVIKVVWGR EWDELLEKDQ DGALVEIMNN TSDGDYQTFK ANDGAYVREH
370 380 390 400 410 420
FFGRDPRTAK LVENMTDEEI WKLPRGGHDY RKVYAAYKRA LETKDRPTVI LAHTIKGYGL
430 440 450 460 470 480
GHNFEGRNAT HQMKKLTLDD LKLFRDKQGI PITDEQLEKD PYLPPYYHPG EDAPEIKYMK
490 500 510 520 530 540
ERRAALGGYL PERRENYDPI QVPPLDKLRS VRKGSGKQQI ATTMATVRTF KELMRDKGLA
550 560 570 580 590 600
DRLVPIIPDE ARTFGLDSWF PTLKIYNPHG QNYVPVDHDL MLSYREAPEG QILHEGINEA
610 620 630 640 650 660
GSVASFIAAG TSYATHGKAM IPLYIFYSMF GFQRTGDSIW AAADQMARGF LLGATAGRTT
670 680 690 700 710 720
LTGEGLQHMD GHSPVLASTN EGVETYDPSF AYEIAHLVHR GIDRMYGPGK GEDVIYYITI
730 740 750 760 770 780
YNEPTPQPAE PEGLDVEGLH KGIYLYSRGE GTGHEANILA SGVGMQWALK AASILEADYG
790 800 810 820 830 840
VRANIYSATS WVNLARDGAA RNKAQLRNPG ADAGEAFVTT QLKQTSGPYV AVSDFSTDLP
850 860 870 880 890 900
NQIREWVPGD YTVLGADGFG FSDTRPAARR FFNIDAESIV VAVLNSLARE GKIDVSVAAQ
910 920
AAEKFKLDDP TSVSVDPNAP EE