Q8NKG8

PR
Gene name
SLD
Protein name
Delta 8-(E)-sphingolipid desaturase
Names
Species
Kluyveromyces lactis (Yeast) (Candida sphaerica)
KEGG Pathway
ag:BAB93118
EC number
1.14.19.18: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NKG8

Entry ID Method Resolution Chain Position Source
AF-Q8NKG8-F1 Predicted AlphaFoldDB

No variants for Q8NKG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NKG8

No associated diseases with Q8NKG8

2 regional properties for Q8NKG8

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 2 - 77 IPR001199
domain Fatty acid desaturase domain 241 - 515 IPR005804

Functions

Description
EC Number 1.14.19.18 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRVLSRRDI ADRIAKGQTI VIYEDSVLNL DKWIKFHPGG DKSIYHMIGR DATDEMNAYH
70 80 90 100 110 120
DDQTITKFKI WKIGRIDYPW ENMLPPIQGG RFSKIDERDD IGDYDINLTS KWRSVDESNQ
130 140 150 160 170 180
YTKIPKNDRL ASEAEVKIYP KIPQGVVPSL DLKEAYEKKI VVDPAIVSEN YDNERVYEDL
190 200 210 220 230 240
TNFPSLDVKN QEWIASEYRK LHGEITAAGL YQCNYVRYLR EFLRIGTLFG ISFYLLSLKW
250 260 270 280 290 300
FAISAICLGF AWQQLVFIAH DAGHISITHN YQVDNIIGMT VASWIGGLSL GWWKRNHDVH
310 320 330 340 350 360
HLVTNDPVHD PDIQHLPFFA VSTRLFHNVY STYYDKFLWF DKFAQKVVPI QHYLYYPILC
370 380 390 400 410 420
FGRFNLYRLS WMHVLLGQGP RRGKAAWFRY YELAELSFFN YWFFYLIIYK QMPTNAERFK
430 440 450 460 470 480
YVMISHIATM IVHVQITLSH FAMSTSDLGV TESFPMRQLR TSMDVDCPRW LDFFHGGLQF
490 500 510 520 530 540
QVIHHLFPRL PRHNLKDAQS LVIKFCDKVG IKYSIYGFAA GNDVVISHLQ QIAQQAHTML
550 560 570
ECAKTMKKEA TDTEFHTNKH VLAANVNEKR KQE