Q8NK50

PR
Gene name
lxr1
Protein name
NADP-dependent mannitol dehydrogenase
Names
MtDH, Mannitol 2-dehydrogenase [NADP(+)]
Species
Hypocrea jecorina (Trichoderma reesei)
KEGG Pathway
trr:M419DRAFT_121678
EC number
1.1.1.138: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NK50

Entry ID Method Resolution Chain Position Source
AF-Q8NK50-F1 Predicted AlphaFoldDB

No variants for Q8NK50

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NK50

No associated diseases with Q8NK50

No regional properties for Q8NK50

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8NK50

Functions

Description
EC Number 1.1.1.138 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
L-xylulose reductase (NADP+) activity Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH.
mannitol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

3 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
mannitol metabolic process The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.
xylulose metabolic process The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPQPVPTANR LLDLFSLKGK VVVVTGASGP RGMGIEAARG CAEMGADLAI TYSSRKEGAE
70 80 90 100 110 120
KNAEELTKEY GVKVKVYKVN QSDYNDVERF VNQVVSDFGK IDAFIANAGA TANSGVVDGS
130 140 150 160 170 180
ASDWDHVIQV DLSGTAYCAK AVGAHFKKQG HGSLVITASM SGHVANYPQE QTSYNVAKAG
190 200 210 220 230 240
CIHLARSLAN EWRDFARVNS ISPGYIDTGL SDFIDEKTQE LWRSMIPMGR NGDAKELKGA
250 260
YVYLVSDASS YTTGADIVID GGYTTR