Q8NIV6

PR
Gene name
spt-6 (NCU04611)
Protein name
Transcription elongation factor spt-6
Names
Chromatin elongation factor spt-6
Species
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KEGG Pathway
ncr:NCU04611
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-285 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8NIV6

Entry ID Method Resolution Chain Position Source
AF-Q8NIV6-F1 Predicted AlphaFoldDB

No variants for Q8NIV6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8NIV6

No associated diseases with Q8NIV6

10 regional properties for Q8NIV6

Type Name Position InterPro Accession
domain S1 domain 1093 - 1161 IPR003029
domain RNA-binding domain, S1 1092 - 1161 IPR022967
domain Spt6 acidic, N-terminal domain 40 - 125 IPR028083
domain Helix-turn-helix DNA-binding domain of Spt6 282 - 405 IPR028088
domain Transcription elongation factor Spt6, YqgF domain 699 - 854 IPR028231
domain Transcription elongation factor Spt6, helix-hairpin-helix motif 856 - 965 IPR032706
domain Spt6, SH2 domain, C terminus 1301 - 1390 IPR035018
domain Spt6, SH2 domain, N terminus 1207 - 1291 IPR035019
domain Spt6, SH2 domain 1180 - 1388 IPR035420
domain HHH domain 9 974 - 1010 IPR041692

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).
transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
transcription antitermination factor activity, DNA binding Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.

13 GO annotations of biological process

Name Definition
carbon catabolite repression of transcription from RNA polymerase II promoter by glucose A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.
co-transcriptional chromatin reassembly The reestablishment of chromatin structure that was disrupted upon passage of RNA polymerase II during transcription elongation. This process prevents cryptic intragenic transcription initiation.
mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes.
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
positive regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.
regulation of histone H3-K36 methylation Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.
regulation of mRNA 3'-end processing Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.
regulation of transcriptional start site selection at RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNSMRDLID GEAELDDEED DESFDEEAGD RPRRRPNIDD SSEEEEDDED EEEARKIREG
70 80 90 100 110 120
FIVDEDEEDE AEDSDARERR RRKKRRRERE EEEQLDEEDL DLIGEAIPEW ERKPQPQRLK
130 140 150 160 170 180
RGHRDDHRPT ERRGLAEIFS DEDEEHDDRG YGRPSGRAQA DEFDDFIEDD YPEDDEERRH
190 200 210 220 230 240
REEDEEVARP KDRGLNIDTT GLDKDALEDM DAIFGNGEDY EWALQLEEEQ EHAERTKEDI
250 260 270 280 290 300
ELQDVFEPSQ LKEKLLTDED NRIRFNDEPE RFQLDRKAFK NLQMTSDQFK EEARWISNLM
310 320 330 340 350 360
LPSKNLSSEL HGPFNKAVGK VLEFFVIDGV EVPYVFQHRR DYLIHAKKMR NPNRRDDPDA
370 380 390 400 410 420
PEYTVDAEKL LTQDDLWKVL DLDIRFRSFL EKRNALEQTY DKLKEKTRDD ILEEMIRQAQ
430 440 450 460 470 480
SIEELQDLQD YLNFQYSAEL KDLAANDNSA QREIKRAGGR TAQFERIRRS NAYKFVQALG
490 500 510 520 530 540
ITPDRLAKNI LRESSKVTSE DDSRLPDDLA DTLVDADFPT GELVINAARQ MLAEEMFASP
550 560 570 580 590 600
RMRKHFRKNF YGMGIVSCRR TDKGLRKIDE ANPYYEVKYL KNMSIADLAV RPELFLKMMK
610 620 630 640 650 660
AEEEGLIEIK VSLENDREFR QQLFSDFASE NFSELADKWN AERQKVIDLA FDKLVKVIVK
670 680 690 700 710 720
GVKDSLRTAC QDELLKTCRE LYFKRLDQAP YKPKGMVIGT TPRVLTLSNG MGDPNREPVS
730 740 750 760 770 780
WVSMDEDGRI LEHGTFTNLA RDESQREALA ELVRRRQPDV IGISGFSADT HRLIKDVEGL
790 800 810 820 830 840
VSEKGLVGPE YDDPETNEYR SDLLEVIVIN DEVARLYKDS PRAVADHPSL NPMTRYCIAL
850 860 870 880 890 900
ARYMQNPMKE YAALGKDVTS LQIHPYQQYL PQAKLLKHLE TAMVDMVNLV GVDINVAMQD
910 920 930 940 950 960
ANTAHLLPYV AGLGPRKAQL LIKGINKNGG VVTSRDELVG DPERHKLPVL GPRVWNNCAS
970 980 990 1000 1010 1020
FLFIEYEPTN PESDPLDNTR IHPEDYDLAR KVAADALGLD EEDVKAETDE NGAGAIVRKL
1030 1040 1050 1060 1070 1080
FKDDEQDKVN ELILEEYAEQ LEREYQQRKR ATLETIRAEL QVPYEELRKK FESLTVDQVF
1090 1100 1110 1120 1130 1140
TMLTGENRDS LCEGMIVAAN VRVVKDDFAI VKLDCGIEGR IESHDVSYRH SIKDVLHVGQ
1150 1160 1170 1180 1190 1200
VVQAKLIDLN RKEFVSKLSM RDEEMRRPFR RHFDHGRDQW DYRKEDEDRE ELREKDKSTG
1210 1220 1230 1240 1250 1260
RAQRVVNHPL FKPFNSTQAE EYLGSQPSGE VVIRPSSKGN DHLAVTWKVA DGVFQHVDVL
1270 1280 1290 1300 1310 1320
ELQKENEFAV GRVLRVGKYT YQDLDELIVD HVKAMAKKVD ELMQCDKFQK GSRNETEKWL
1330 1340 1350 1360 1370 1380
TTYMDANPNR STYAFCIDTK HPGYFFLCFK ASRNSRVNAW PVRVIPHAFE LMKSQYPDVR
1390 1400
ALCNGFKLRY QSEMLKQQSG GR