AiPD: Autoinhibited Protein Database

Q8NEK8

Gene name	TENT5D
Protein name	Terminal nucleotidyltransferase 5D
Names	Non-canonical poly(A) polymerase FAM46D
Species	Homo sapiens (Human)
KEGG Pathway	hsa:169966
EC number	2.7.7.19: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-156 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

85-156 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NEK8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NEK8-F1	Predicted				AlphaFoldDB

194 variants for Q8NEK8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10461436 rs747484824	2	S>F		No	ClinGen ExAC gnomAD
CA413742764 rs1180055460	7	T>I		No	ClinGen TOPMed
CA10461438 rs777296127	8	N>S		No	ClinGen ExAC TOPMed gnomAD
rs17855533 CA331814065	10	T>A		No	ClinGen Ensembl
CA413742787 rs1258045947	11	W>L		No	ClinGen TOPMed
CA413742816 rs1180834617	15	I>V		No	ClinGen gnomAD
CA413742823 rs1569376798	16	T>A		No	ClinGen Ensembl
rs1412013907 CA413742826	16	T>R		No	ClinGen gnomAD
TCGA novel	18	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461439 rs759757458	18	D>Y		No	ClinGen ExAC gnomAD
rs370538052 CA10461440	22	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1031757178 CA331814067	22	D>H		No	ClinGen Ensembl
rs773874789 CA10461441	24	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1263083696 CA413742949	34	P>L		No	ClinGen TOPMed gnomAD
rs151135944 CA331814068 CA331814069	36	M>I		No	ClinGen ESP TOPMed gnomAD
rs766993924 CA10461443	36	M>V		No	ClinGen ExAC gnomAD
rs749977497 CA10461444	37	E>D		No	ClinGen ExAC gnomAD
rs955765761 CA331814070	40	P>S		No	ClinGen Ensembl
rs766257081 CA10461446 COSM3845458	42	D>Y	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA
CA10461447 rs140244380	45	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1313284280 CA413743032	47	V>M		No	ClinGen gnomAD
TCGA novel	49	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413743053 rs1243369308	50	Q>E		No	ClinGen gnomAD
TCGA novel	52	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461448 rs375165939	53	G>E		No	ClinGen ESP ExAC gnomAD
TCGA novel	54	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461451 rs368099663	57	I>M		No	ClinGen ESP ExAC gnomAD
rs780229845 CA331814071	59	K>R		No	ClinGen Ensembl
CA331814072 rs914512365	60	D>N		No	ClinGen Ensembl
TCGA novel	60	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461455 rs137952753	67	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs746458461 CA10461456	73	A>E		No	ClinGen ExAC gnomAD
CA10461458 rs372407342	76	N>S		No	ClinGen ESP ExAC gnomAD
rs1374230339 CA413743240	78	I>V		No	ClinGen TOPMed gnomAD
rs1428845173 CA413743249	79	S>N		No	ClinGen gnomAD
CA10461459 rs375689010	80	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	83	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA331814074 rs992431399 COSM252500	85	V>I	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1292959702 CA413743298	86	I>S		No	ClinGen gnomAD
rs1463001407 CA413743296	86	I>V		No	ClinGen TOPMed
CA413743315 rs1368926663	88	G>D		No	ClinGen gnomAD
TCGA novel	88	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201702381 CA10461461	93	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs141007953 CA10461463 COSM1125786	95	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA413743386 rs1263515934 COSM1125787	99	V>I	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	101	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461464 rs753705045	103	A>S		No	ClinGen ExAC gnomAD
CA331814076 rs113640425	104	V>A		No	ClinGen Ensembl
rs754990371 CA10461465	105	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1188512085 CA413743431	106	D>A		No	ClinGen TOPMed
CA331814077 rs186689398	108	L>P		No	ClinGen 1000Genomes
CA331814078 rs768827836	109	L>P		No	ClinGen TOPMed gnomAD
rs150129047 CA10461468	111	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	113	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs189602496 CA10461471	114	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs781393813 CA10461472	115	D>Y		No	ClinGen ExAC gnomAD
rs1422907488 CA413743508	117	K>N		No	ClinGen gnomAD
CA10461475 rs780459324	119	E>G		No	ClinGen ExAC gnomAD
rs1459491585 CA413743533	121	L>I		No	ClinGen TOPMed gnomAD
rs1287697168 CA413743542	122	S>F		No	ClinGen TOPMed gnomAD
CA10461476 rs749617118	123	P>A		No	ClinGen ExAC gnomAD
CA10461477 rs769022513	123	P>L		No	ClinGen ExAC TOPMed gnomAD
rs779051485 CA10461478	125	I>T		No	ClinGen ExAC TOPMed gnomAD
rs374685215 CA413743585	128	D>E		No	ClinGen ESP TOPMed gnomAD
rs1569376984 CA413743587	129	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA10461480 rs188396741	131	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	132	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461482 rs758997189	137	V>I		No	ClinGen ExAC TOPMed gnomAD
CA331814082 rs765171207	139	N>K		No	ClinGen ExAC gnomAD
rs201318635 CA331814081	139	N>S		No	ClinGen Ensembl
CA10461484 rs752587473	141	H>R		No	ClinGen ExAC gnomAD
rs1249626200 CA413743687	143	C>S		No	ClinGen TOPMed gnomAD
rs1443036303 CA413743703	145	S>N		No	ClinGen gnomAD
TCGA novel	147	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA331814083 rs1008391005	153	T>A		No	ClinGen gnomAD
rs1008391005 CA413743755	153	T>S		No	ClinGen gnomAD
TCGA novel	154	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	160	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	161	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	167	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	171	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413743933 rs1569377031	178	I>V		No	ClinGen Ensembl
rs750478659 CA10461490	179	V>F		No	ClinGen ExAC
CA10461492 rs780554117	182	P>S		No	ClinGen ExAC gnomAD
rs749800137 CA10461493	183	M>V		No	ClinGen ExAC gnomAD
rs1113265 VAR_028980 CA10461495	185	D>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10461494 rs143862091	185	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	186	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461496 rs746631425	187	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	190	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	191	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs140859426 CA10461497	193	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1285833898 CA413744041	193	K>R		No	ClinGen gnomAD
TCGA novel	194	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461498 rs776167652	197	E>D		No	ClinGen ExAC TOPMed gnomAD
CA413744076 rs1228884980	198	S>F		No	ClinGen TOPMed gnomAD
CA10461499 rs61755189	199	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10461501 rs775490438	201	V>A		No	ClinGen ExAC gnomAD
CA413744090 rs1198117082	201	V>I		No	ClinGen gnomAD
CA10461502 rs763046111	203	V>A		No	ClinGen ExAC gnomAD
CA331814084 rs959936581	203	V>I		No	ClinGen gnomAD
rs959936581 CA413744101	203	V>L		No	ClinGen gnomAD
rs763963851 CA10461503	207	M>T		No	ClinGen ExAC gnomAD
rs139370296 CA331814085	207	M>V		No	ClinGen ESP
CA413744139 rs1162047609	208	Y>F		No	ClinGen gnomAD
TCGA novel	212	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs112952835 CA331814086	212	Q>R		No	ClinGen Ensembl
rs1177167865 CA413744191	215	M>I		No	ClinGen TOPMed gnomAD
CA331814087 rs774402950	220	H>Q		No	ClinGen 1000Genomes
CA413744238 rs1442580536	222	L>I		No	ClinGen TOPMed
rs1449721198 CA413744245	223	I>V		No	ClinGen gnomAD
CA10461507 rs750626708	226	R>K		No	ClinGen ExAC gnomAD
TCGA novel	228	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290197935 CA413744301	231	I>F		No	ClinGen gnomAD
TCGA novel	237	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	238	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754320744 CA10461510	244	V>I		No	ClinGen ExAC gnomAD
CA413744450 rs1330089419	252	M>I		No	ClinGen TOPMed
CA413744452 rs1279017345	253	S>P		No	ClinGen gnomAD
CA10461511 rs755519479 COSM1558823	256	K>R	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA413744484 rs1177074819	257	N>T		No	ClinGen gnomAD
CA413744505 rs1203339422	260	R>H		No	ClinGen gnomAD
COSM1125790 CA413744552 rs1389660181	266	F>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	267	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413744562 rs1398521393	268	I>V		No	ClinGen TOPMed
rs867317346 CA331814088	269	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs779425399 CA413744599	273	I>L		No	ClinGen ExAC gnomAD
rs779425399 CA10461512	273	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs908650103 CA331814089	277	Q>K		No	ClinGen TOPMed gnomAD
CA413744631 rs1465389705	277	Q>R		No	ClinGen TOPMed
rs767337141 COSM1570012 CA10461513	278	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA
rs1569377132 CA413744638	278	K>T		No	ClinGen Ensembl
CA413744691 rs1375674137	285	H>Q		No	ClinGen TOPMed
CA413744697 COSM1125791 rs1184424430	286	N>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	288	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413744757 rs1477950275	294	T>I		No	ClinGen gnomAD
rs1602226737 CA413744823	303	H>R		No	ClinGen Ensembl
rs1166375789 CA413744873	310	T>S		No	ClinGen TOPMed gnomAD
CA10461515 rs780828007	311	V>L		No	ClinGen ExAC
CA413744897 rs770805267	314	M>R		No	ClinGen gnomAD
rs770805267 CA331814091	314	M>T		No	ClinGen gnomAD
rs745569596 CA10461516	316	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs745569596 CA331814092	316	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1569377170 CA413744917	317	E>Q		No	ClinGen Ensembl
CA10461519 rs749210548	324	L>R		No	ClinGen ExAC gnomAD
CA413744979 rs1275347687	326	T>A		No	ClinGen TOPMed gnomAD
CA413744980 rs1275347687	326	T>S		No	ClinGen TOPMed gnomAD
rs1369514964 CA413744992	327	M>I		No	ClinGen gnomAD
CA10461521 COSM1558822 rs774454958	328	M>I	lung [Cosmic]	No	ClinGen cosmic curated ExAC
CA10461520 rs768676599	328	M>R		No	ClinGen ExAC gnomAD
rs369436155 CA10461524	340	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1200263892 CA413745077	341	N>D		No	ClinGen gnomAD
CA10461526 rs766451023	341	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10461527 rs200280082	342	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA10461528 rs201641735	344	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	349	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA413745145 CA413745146 rs1373395298	350	Q>H		No	ClinGen TOPMed
TCGA novel	350	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461529 rs765671795	350	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs776148348 CA10461530	353	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1158108919 CA413745191	357	A>V		No	ClinGen TOPMed
CA413745201 rs1302690239	359	A>S		No	ClinGen gnomAD
rs1343731241 CA413745209	360	R>T		No	ClinGen gnomAD
CA10461532 rs778054141	361	Y>H		No	ClinGen ExAC gnomAD
CA10461533 rs745515047	363	I>T		No	ClinGen ExAC gnomAD
CA331814095 rs765852551	364	Y>N		No	ClinGen 1000Genomes
rs1351532398 CA413745240	365	V>I		No	ClinGen gnomAD
rs1225823486 CA413745258	368	E>K		No	ClinGen gnomAD
TCGA novel	369	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779886301 CA10461537	370	P>L		No	ClinGen ExAC gnomAD
CA10461536 rs755766205	370	P>S		No	ClinGen ExAC TOPMed gnomAD
CA413745273 rs755766205	370	P>T		No	ClinGen ExAC TOPMed gnomAD
rs748762113 CA10461538	371	P>A		No	ClinGen ExAC TOPMed gnomAD
rs768296665 CA10461539 COSM1469579	372	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1284909928 CA413745289	373	S>N		No	ClinGen TOPMed
CA10461540 rs774366777	373	S>R		No	ClinGen ExAC
CA10461541 rs748101488	374	F>S		No	ClinGen ExAC gnomAD
rs376757382 CA10461542	377	Y>C		No	ClinGen ESP ExAC gnomAD
CA413745314 rs1352237872	377	Y>H		No	ClinGen TOPMed
CA10461543 rs772919719	378	H>P		No	ClinGen ExAC TOPMed gnomAD
rs760549896 CA10461544	378	H>Q		No	ClinGen ExAC gnomAD
CA413745323 rs1208526491	378	H>Y		No	ClinGen gnomAD
rs17855532 CA331814096	382	F>L		No	ClinGen Ensembl
rs776851281 CA413745352	382	F>L		No	ClinGen ExAC TOPMed gnomAD
COSM1558821 CA10461547 rs199636557	383	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA10461548 rs765366405	383	R>H		No	ClinGen ExAC TOPMed gnomAD
CA413745353 rs199636557	383	R>S		No	ClinGen ExAC gnomAD
rs1163273853 CA413745360	384	G>E		No	ClinGen gnomAD
rs538071284 CA331814097	385	S>L		No	ClinGen Ensembl
CA10461549 rs759085757	385	S>T		No	ClinGen ExAC TOPMed gnomAD
CA10461550 rs763415283	386	N>S		No	ClinGen ExAC gnomAD
TCGA novel	387	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10461551 rs145427021	388	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA413745400 rs1339554927	390	S>L		No	ClinGen TOPMed

No associated diseases with Q8NEK8

No regional properties for Q8NEK8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8NEK8

Functions

		Description
EC Number	2.7.7.19	Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name	Definition
polynucleotide adenylyltransferase activity	Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group.
RNA adenylyltransferase activity	Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group.

1 GO annotations of biological process

Name	Definition
mRNA stabilization	Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSEIRFTNLT	WDQVITLDQV	LDEVIPIHGK	GNFPTMEVKP	KDIIHVVKDQ	LIGQGIIVKD
70	80	90	100	110	120
ARLNGSVASY	ILASHNGISY	KDLDVIFGVE	LPGNEEFQVV	KDAVLDCLLD	FLPKDVKKEK
130	140	150	160	170	180
LSPDIMKDAY	VQKLVKVCNG	HDCWSLISLS	NNTGKNLELK	FVSSLRRQFE	FSVDSFQIVL
190	200	210	220	230	240
DPMLDFYSDK	NAKLTKESYP	VVVAESMYGD	FQEAMTHLQH	KLICTRKPEE	IRGGGLLKYC
250	260	270	280	290	300
SLLVHGFKPA	CMSEIKNLER	YMCSRFFIDF	PHIEEQQKKI	ESYLHNHFIG	EGMTKYDYLM
310	320	330	340	350	360
TLHGVVNEST	VCLMSYERRQ	ILHLITMMAL	KVLGELNILP	NTQKVTCFYQ	PAPYFAAEAR
370	380
YPIYVIPEPP	PVSFQPYHPL	HFRGSNGMS