AiPD: Autoinhibited Protein Database

Q8NEA4

Gene name	FBXO36 (FBX36)
Protein name	F-box only protein 36
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:130888
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-95 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-95 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NEA4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NEA4-F1	Predicted				AlphaFoldDB

194 variants for Q8NEA4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA67438784 rs952250104	2	A>V		No	ClinGen TOPMed gnomAD
CA351148356 rs577947245	3	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA351148353 rs1183226005	3	S>P		No	ClinGen TOPMed
CA2153625 rs577947245	3	S>W		No	ClinGen 1000Genomes ExAC gnomAD
rs749345823 CA2153628	4	W>*		No	ClinGen ExAC TOPMed gnomAD
rs370957305 CA2153627	4	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA2153629 rs769314957	6	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1166514747 CA351148372	6	P>L		No	ClinGen gnomAD
CA351148369 rs769314957	6	P>S		No	ClinGen ExAC TOPMed gnomAD
CA2153630 rs769314957	6	P>T		No	ClinGen ExAC TOPMed gnomAD
CA67438785 rs74794441	7	E>G		No	ClinGen ExAC gnomAD
rs762423299 CA2153631	7	E>K		No	ClinGen ExAC TOPMed gnomAD
rs762423299 CA351148373	7	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA2153632 rs74794441	7	E>V		No	ClinGen ExAC gnomAD
rs1553798655 CA2153634	8	T>A		No	ClinGen Ensembl
CA351148382 rs1481793717	8	T>I		No	ClinGen gnomAD
rs202219810 CA2153636	9	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA gnomAD
CA2153637 rs765923907	10	F>I		No	ClinGen ExAC gnomAD
rs759130535 CA67438786	10	F>S		No	ClinGen Ensembl
CA2153638 rs753556519	12	T>A		No	ClinGen ExAC gnomAD
rs759036863 CA2153639 CA2153640	14	G>R		No	ClinGen ExAC TOPMed gnomAD
rs887670235 CA67438788	15	Q>*		No	ClinGen TOPMed
rs1354424549 CA351148427	16	G>A		No	ClinGen TOPMed
CA67438789 rs1006544293	16	G>R		No	ClinGen TOPMed
rs1306732381 CA351148434	17	P>L		No	ClinGen TOPMed
rs1366653677 CA351148440	18	P>L		No	ClinGen TOPMed
rs1484676626 CA351148443	19	P>S		No	ClinGen TOPMed gnomAD
rs1410207060 CA351148449	20	S>R		No	ClinGen TOPMed
CA351148455 rs1479769544	21	K>Q		No	ClinGen TOPMed gnomAD
rs183069679 CA2153642	22	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1417932696 CA351148468 CA351148467	22	D>E		No	ClinGen gnomAD
rs183069679 CA2153643	22	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1183471382 CA351148464	22	D>N		No	ClinGen gnomAD
CA351148473 rs1419898008	23	Y>*		No	ClinGen gnomAD
rs769504180 CA2153646	23	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs751292712 CA2153644	23	Y>D		No	ClinGen ExAC gnomAD
rs751292712 CA2153645	23	Y>N		No	ClinGen ExAC gnomAD
CA2153648 rs749576716	25	Q>H		No	ClinGen ExAC gnomAD
rs755046970 CA2153649	26	L>*		No	ClinGen ExAC gnomAD
CA351148493 rs1305044394	26	L>F		No	ClinGen gnomAD
rs755046970 CA351148491	26	L>S		No	ClinGen ExAC gnomAD
CA351148497 rs1403023531	27	L>Q		No	ClinGen gnomAD
CA67438790 rs921972194	29	T>S		No	ClinGen Ensembl
rs779134417 CA2153650	30	R>W		No	ClinGen ExAC gnomAD
CA2153651 rs748648208	31	S>C		No	ClinGen ExAC gnomAD
rs1379443271 CA351148525	32	Q>R		No	ClinGen TOPMed gnomAD
rs1341099988 CA351148903	34	I>S		No	ClinGen gnomAD
rs138308951 CA2153679	35	F>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2153681 rs147327260	36	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs767376456 CA2153683	38	W>*		No	ClinGen ExAC gnomAD
CA2153684 rs548696958	38	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1288560009 CA351148948	40	I>M		No	ClinGen gnomAD
CA351148943 rs1214992304	40	I>V		No	ClinGen gnomAD
rs1176919837 CA351148958	42	L>P		No	ClinGen TOPMed
CA2153686 rs765523966	43	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753027700 CA2153687	43	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1182508707 CA351148985	46	Y>C		No	ClinGen TOPMed gnomAD
CA2153688 rs377169424	47	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2153689 rs201887524	47	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1227455059 CA351148992	48	S>T		No	ClinGen gnomAD
CA67445039 rs1004251485	49	T>A		No	ClinGen Ensembl
rs1214108958 CA351149003	50	K>Q		No	ClinGen TOPMed
rs757788370 CA2153691	51	P>R		No	ClinGen ExAC gnomAD
rs61753284 CA2153690	51	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781703291 CA2153692	52	G>R		No	ClinGen ExAC gnomAD
CA351149042 rs1360397845	56	E>K		No	ClinGen TOPMed gnomAD
rs770212604 CA2153694	57	T>S		No	ClinGen ExAC TOPMed gnomAD
CA351149056 rs187530910	58	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351149059 rs1341613510	58	H>Q		No	ClinGen TOPMed
rs139081403 CA2153697	58	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2153696 rs187530910	58	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1241839113 CA351149062	59	E>Q		No	ClinGen gnomAD
CA351149082 rs1277986774	61	F>C		No	ClinGen TOPMed
TCGA novel	61	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA67445040 rs975650207	62	L>P		No	ClinGen Ensembl
CA2153699 rs773938730	63	E>G		No	ClinGen ExAC gnomAD
CA351149090 rs1311961665	63	E>Q		No	ClinGen gnomAD
CA2153702 rs200544029	66	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs968852269 CA67445041	66	H>P		No	ClinGen TOPMed
CA2153701 rs200544029	66	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351149115 rs1560447290	67	L>I		No	ClinGen Ensembl
CA2153703 rs371928808	68	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1391771236 CA351149432	72	A>V		No	ClinGen TOPMed
CA2153728 rs201098656	73	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA351149440 rs1437808839	74	I>V		No	ClinGen gnomAD
rs1049793522 CA67447252	77	A>G		No	ClinGen TOPMed
rs145930016 CA67447253 COSM221481 COSM221482	79	I>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
TCGA novel	79	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143439395 COSM1017557 CA2153730	82	Y>C	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
TCGA novel	83	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351149510 rs1220613487	84	I>T		No	ClinGen gnomAD
TCGA novel	85	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1057372884 CA67447254	85	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2153731 VAR_045626 rs1035834	86	L>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766599623 CA2153732	87	C>Y		No	ClinGen ExAC gnomAD
rs574202659 CA2153734	92	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351149565 rs1346275291	92	D>N		No	ClinGen TOPMed
rs1300277713 CA351149568	92	D>V		No	ClinGen TOPMed
rs755336934 CA2153735	93	F>I		No	ClinGen ExAC gnomAD
rs1478744991 CA351149585	95	E>K		No	ClinGen TOPMed gnomAD
CA2153737 rs747866198	96	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2153736 COSM1017560 rs140479647	96	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs970524734 CA67447255	97	L>V		No	ClinGen Ensembl
rs746894162 CA2153740	100	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA351149628 rs1033384470	101	L>F		No	ClinGen TOPMed gnomAD
rs770879889 CA2153741	103	L>V		No	ClinGen ExAC gnomAD
TCGA novel	105	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776477646 CA2153742	105	I>V		No	ClinGen ExAC gnomAD
rs1402373132 CA351149669	108	Y>F		No	ClinGen gnomAD
rs747276723 CA67447257	109	L>V		No	ClinGen Ensembl
CA351149681 TCGA novel rs1577361285	110	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
rs1278941273 CA351149686	111	L>V		No	ClinGen gnomAD
rs1189187316 CA351149693	112	E>G		No	ClinGen TOPMed
CA2153743 rs745676136	112	E>K		No	ClinGen ExAC TOPMed gnomAD
CA67447258 rs754629116	113	D>Y		No	ClinGen Ensembl
CA2153744 rs769538225	114	I>T		No	ClinGen ExAC gnomAD
CA67447260 rs984339155	114	I>V		No	ClinGen Ensembl
CA67447262 rs1039324823	116	R>S		No	ClinGen TOPMed gnomAD
CA2153747 rs140140630	118	C>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs140140630 CA2153746	118	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773298727 CA2153748	120	T>I		No	ClinGen ExAC gnomAD
rs760713596 CA2153749	124	F>L		No	ClinGen ExAC gnomAD
CA2153750 rs766877980	125	A>T		No	ClinGen ExAC gnomAD
CA351149778 rs1254881487	125	A>V		No	ClinGen gnomAD
CA351149779 rs1339102866	126	K>E		No	ClinGen TOPMed
CA351150596 rs1378857071	128	C>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2153768 rs760804470	129	M>I		No	ClinGen ExAC gnomAD
rs1441996228 CA351150602	129	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2153771 rs772081678	134	W>*		No	ClinGen ExAC TOPMed gnomAD
CA2153772 rs765649952	135	E>D		No	ClinGen ExAC
rs1003819693 CA67448830	135	E>K		No	ClinGen Ensembl
rs1402954300 CA351150652	136	Q>*		No	ClinGen TOPMed gnomAD
rs1402954300 CA351150651	136	Q>E		No	ClinGen TOPMed gnomAD
CA351150650 rs1402954300	136	Q>K		No	ClinGen TOPMed gnomAD
rs753089890 CA2153773	137	I>T		No	ClinGen ExAC gnomAD
CA351150664 rs1329496171	138	V>I		No	ClinGen gnomAD
CA351150681 rs763837354	140	S>*		No	ClinGen ExAC TOPMed gnomAD
CA2153775 rs763837354	140	S>L		No	ClinGen ExAC TOPMed gnomAD
CA351150682 rs763837354	140	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1577369239 CA351150688	141	T>I		No	ClinGen Ensembl
rs149438648 CA351150695	142	C>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2153779 rs149438648	142	C>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2153780 rs756065810	143	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1196383425 CA351150715	145	I>M		No	ClinGen TOPMed gnomAD
CA351150709 rs1316675323	145	I>V		No	ClinGen gnomAD
rs942514590 CA67448832	147	P>S		No	ClinGen TOPMed gnomAD
rs1431982848 CA351150738	149	V>A		No	ClinGen TOPMed gnomAD
CA351150736 rs749047441	149	V>L		No	ClinGen ExAC TOPMed gnomAD
rs749047441 CA2153782	149	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	151	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2153783 rs148144704	152	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs200898703 CA351150761	153	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200898703 CA2153784	153	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA67448833 rs955560425	155	D>G		No	ClinGen Ensembl
rs377398090 CA67448834	156	T>I		No	ClinGen ESP TOPMed
rs1168613249 CA351150784	157	G>R		No	ClinGen gnomAD
rs1435824441 CA351150791	158	W>*		No	ClinGen gnomAD
TCGA novel	158	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402776882 CA351150797	159	R>G		No	ClinGen gnomAD
rs1292748455 CA351150808	160	Q>R		No	ClinGen gnomAD
TCGA novel	162	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1365173900 CA351150821	162	F>S		No	ClinGen gnomAD
CA351150826 rs1206413054	163	F>L		No	ClinGen gnomAD
rs987382559 CA67448835	164	T>N		No	ClinGen Ensembl
CA2153787 rs770975794	165	N>H		No	ClinGen ExAC TOPMed gnomAD
CA67448836 rs61753285	166	K>E		No	ClinGen Ensembl
CA2153788 rs776597799	166	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1577369311 CA351150858	168	Q>*		No	ClinGen Ensembl
rs759712484 CA2153789	169	L>P		No	ClinGen ExAC TOPMed gnomAD
rs942808736 CA67448837	169	L>V		No	ClinGen Ensembl
CA351150869 rs1475550608	170	Q>*		No	ClinGen TOPMed
TCGA novel	170	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2153792 rs747143681	171	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2153791 rs139190280	171	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2153795 rs144985086	172	Q>L		No	ClinGen ESP ExAC gnomAD
CA2153796 rs144985086	172	Q>P		No	ClinGen ESP ExAC gnomAD
rs749873884 CA2153797	173	L>P		No	ClinGen ExAC gnomAD
CA351150893 rs1487679217	174	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs145410117 CA2153798	174	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA2153799 rs145410117	174	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs946076112 CA67448838	176	R>T		No	ClinGen Ensembl
CA351150912 rs1440739009	177	K>T		No	ClinGen TOPMed
CA2153802 rs754707759	178	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA351150924 rs1425802486	179	K>Q		No	ClinGen gnomAD
CA2153803 rs778575480	180	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1577369364 CA351150932	180	Y>N		No	ClinGen Ensembl
rs1459301141 CA351150941	181	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA2153805 rs757400653	181	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1339816013 CA351150950	182	N>K		No	ClinGen gnomAD
rs1560460037 CA351150957	184	R>G		No	ClinGen Ensembl
rs368835857 CA67448839	184	R>K		No	ClinGen Ensembl
CA67448840 rs572054995	185	E>K		No	ClinGen 1000Genomes gnomAD
CA2153806 rs142486766	188	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA2153807 rs745938616	189	P>Y		No	ClinGen ExAC gnomAD

No associated diseases with Q8NEA4

1 regional properties for Q8NEA4

Type	Name	Position	InterPro Accession
domain	F-box domain	91 - 137	IPR001810

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UK96	FBXO10	F-box only protein 10	Homo sapiens (Human)	PR
Q7TQF2	Fbxo10	F-box only protein 10	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MASWLPETLF	ETVGQGPPPS	KDYYQLLVTR	SQVIFRWWKI	SLRSEYRSTK	PGEAKETHED
70	80	90	100	110	120
FLENSHLQGQ	TALIFGARIL	DYVINLCKGK	FDFLERLSDD	LLLTIISYLD	LEDIARLCQT
130	140	150	160	170	180
SHRFAKLCMS	DKLWEQIVQS	TCDTITPDVR	ALAEDTGWRQ	LFFTNKLQLQ	RQLRKRKQKY

GNLREKQP