AiPD: Autoinhibited Protein Database

Q8NCQ7

Gene name	PROCA1
Protein name	Protein PROCA1
Names	Protein interacting with cyclin A1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:147011
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

244-324 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

244-324 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NCQ7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NCQ7-F1	Predicted				AlphaFoldDB

330 variants for Q8NCQ7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1418534400 CA398393461	2	W>*		No	ClinGen gnomAD
rs1186571637 CA398393436	4	R>G		No	ClinGen gnomAD
CA398393422 rs1244395843	4	R>K		No	ClinGen gnomAD
CA8465874 rs772508942	7	L>F		No	ClinGen ExAC TOPMed gnomAD
CA8465873 rs772508942	7	L>I		No	ClinGen ExAC TOPMed gnomAD
CA8465871 rs200984168	9	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs564467384 CA8465872	9	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1217110627 CA398393327	11	R>G		No	ClinGen gnomAD
CA8465870 rs768961503	12	W>R		No	ClinGen ExAC gnomAD
CA8465869 rs749445488	13	T>A		No	ClinGen ExAC gnomAD
CA289127312 rs749445488	13	T>P		No	ClinGen ExAC gnomAD
rs1240121519 CA398393283	14	K>E		No	ClinGen TOPMed
CA398393278 rs1597744533	14	K>T		No	ClinGen Ensembl
CA398393259 rs769738771	15	E>*		No	ClinGen ExAC gnomAD
CA8465867 rs769738771	15	E>K		No	ClinGen ExAC gnomAD
CA8465866 rs781340036	16	K>N		No	ClinGen ExAC gnomAD
rs1289607154 CA398393195	19	P>S		No	ClinGen gnomAD
CA398393182 rs1447122831	20	K>Q		No	ClinGen TOPMed gnomAD
rs751124321 CA8465863	20	K>R		No	ClinGen ExAC gnomAD
CA398393157 rs777128011	21	A>D		No	ClinGen ExAC gnomAD
CA398393168 rs1343720854	21	A>T		No	ClinGen gnomAD
CA8465862 rs777128011	21	A>V		No	ClinGen ExAC gnomAD
CA398393152 rs1418420049	22	R>C		No	ClinGen gnomAD
CA289127275 rs934230814	22	R>H		No	ClinGen TOPMed
CA8465860 rs752325880	24	W>*		No	ClinGen ExAC gnomAD
rs1421045391 CA398393129	24	W>*		No	ClinGen gnomAD
rs1473903475 CA398393135	24	W>R		No	ClinGen gnomAD
CA8465858 rs761042157	25	D>G		No	ClinGen ExAC gnomAD
rs764803635 CA8465859	25	D>Y		No	ClinGen ExAC gnomAD
CA398391159 rs1310723946	28	L>V		No	ClinGen gnomAD
CA398391134 rs1422065710	29	S>L		No	ClinGen gnomAD
rs144816976 CA289123258	30	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs144816976 CA8465836	30	D>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1208754525 CA398391086	32	N>K		No	ClinGen TOPMed
rs907499934 CA289123252	32	N>S		No	ClinGen Ensembl
TCGA novel	37	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1182150112 CA398390956	38	E>K		No	ClinGen TOPMed
rs1364755895 CA398390928	39	R>K		No	ClinGen TOPMed gnomAD
CA289123248 rs951834752	40	G>E		No	ClinGen Ensembl
CA8465835 rs563545838	40	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA398390850 rs1185759261	44	A>D		No	ClinGen TOPMed
TCGA novel	45	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA289123242 rs1034087453	46	V>E		No	ClinGen TOPMed gnomAD
CA398390825 rs1420706855	46	V>M		No	ClinGen gnomAD
rs1457788717 CA398390809	47	A>T		No	ClinGen TOPMed
CA8465834 rs764592123	47	A>V		No	ClinGen ExAC gnomAD
CA398390628 rs1410604331	52	V>A		No	ClinGen TOPMed
rs578067125 CA289123233	53	S>P		No	ClinGen 1000Genomes
rs1486348966 CA398390600	54	T>A		No	ClinGen gnomAD
CA398390578 rs1191223926	55	F>L		No	ClinGen TOPMed gnomAD
rs1261090655 CA398390479	58	G>C		No	ClinGen gnomAD
rs1238111250 CA398390474	58	G>D		No	ClinGen gnomAD
CA8465825 rs746751574	59	G>D		No	ClinGen ExAC gnomAD
CA289122581 rs920625259	63	E>D		No	ClinGen gnomAD
rs1184389908 CA398389257	63	E>G		No	ClinGen TOPMed
rs773038403 CA8465824	65	D>G		No	ClinGen ExAC gnomAD
TCGA novel	65	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326635152 CA398389104	71	H>P		No	ClinGen gnomAD
rs916044523 CA289122520	72	K>M		No	ClinGen Ensembl
rs779638032 CA8465817	74	C>R		No	ClinGen ExAC gnomAD
rs1301073188 CA398389012	74	C>Y		No	ClinGen TOPMed gnomAD
rs753207202 CA8465813	79	I>T		No	ClinGen ExAC TOPMed gnomAD
CA289122478 rs369933235	79	I>V		No	ClinGen ESP TOPMed
CA398388843 rs1597731653	80	Y>S		No	ClinGen Ensembl
rs960230823 CA289122466	81	P>R		No	ClinGen gnomAD
rs758909804 CA8465811	81	P>S		No	ClinGen ExAC gnomAD
rs752877417 CA8465810	82	F>L		No	ClinGen ExAC TOPMed gnomAD
rs765433249 CA398388769	83	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8465809 rs765433249	83	A>T		No	ClinGen ExAC TOPMed gnomAD
CA398388619 rs1597731588	87	V>A		No	ClinGen Ensembl
CA8465805 rs776997644	88	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8465806 rs776997644	88	R>G		No	ClinGen ExAC TOPMed gnomAD
rs138077899 CA8465804	88	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs968759452 CA289122431	89	H>Y		No	ClinGen Ensembl
rs543881952 CA8465803	90	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA8465801 rs771942143	92	H>Y		No	ClinGen ExAC gnomAD
rs146270076 CA8465799	93	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA289122429 rs996511712	94	H>R		No	ClinGen Ensembl
CA8465798 rs768181981	94	H>Y		No	ClinGen ExAC gnomAD
rs1193358374 CA398388431	97	N>S		No	ClinGen TOPMed
rs141862185 CA398388404	98	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA398388389 rs759599083	98	H>Q		No	ClinGen ExAC TOPMed
CA398388393 rs1391968591	98	H>R		No	ClinGen gnomAD
CA8465796 rs141862185	98	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA289122399 rs886969657	99	C>*		No	ClinGen Ensembl
rs1008001735 CA289122404	99	C>F		No	ClinGen Ensembl
TCGA novel	99	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA289122391 rs751847926	101	C>S		No	ClinGen ExAC TOPMed gnomAD
COSM1744186 CA8465794 rs751847926	101	C>Y	biliary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs778179510 CA8465793	102	N>T		No	ClinGen ExAC gnomAD
rs758645795 CA8465792	104	R>K		No	ClinGen ExAC gnomAD
CA8465750 rs780385812	104	R>S		No	ClinGen ExAC TOPMed gnomAD
CA398388132 rs1567713483	106	K>E		No	ClinGen Ensembl
rs1227923485 CA398388081	110	E>K		No	ClinGen gnomAD
rs750408777 CA8465746	112	S>N		No	ClinGen ExAC gnomAD
rs1295085753 CA398388018	113	S>G		No	ClinGen gnomAD
CA398388004 rs1442890192	113	S>R		No	ClinGen gnomAD
TCGA novel	115	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143668972 CA8465744	116	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA8465745 rs148075248 COSM3718521	116	R>W	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1433598147 CA398387969	117	G>S		No	ClinGen gnomAD
CA8465741 rs148946652	118	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs752688160 CA8465740	118	A>V		No	ClinGen ExAC TOPMed gnomAD
rs759143893 CA8465738	120	P>R		No	ClinGen ExAC gnomAD
rs776002091 CA8465737	121	T>I		No	ClinGen ExAC gnomAD
rs369147017 CA398387918	122	C>F		No	ClinGen ESP ExAC gnomAD
CA8465735 rs369147017	122	C>S		No	ClinGen ESP ExAC gnomAD
CA398387896 rs769173190	124	H>P		No	ClinGen ExAC gnomAD
CA8465733 rs769173190	124	H>R		No	ClinGen ExAC gnomAD
CA398387878 rs1482182743	126	I>V		No	ClinGen gnomAD
rs566098264 CA8465731	127	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770184428 CA8465730	128	S>F		No	ClinGen ExAC gnomAD
CA398387859 rs1330976697	129	P>S		No	ClinGen TOPMed
CA398387861 rs1330976697	129	P>T		No	ClinGen TOPMed
rs781215362 CA8465728	130	C>Y		No	ClinGen ExAC gnomAD
rs150328148 CA8465727	134	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374751808 CA8465726	135	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA398387818 rs374751808	135	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA398387817 rs374751808	135	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8465724 rs758229750	136	E>Q		No	ClinGen ExAC gnomAD
rs765286083 CA8465722	137	E>K		No	ClinGen ExAC TOPMed gnomAD
rs754841193 CA8465721	138	E>G		No	ClinGen ExAC gnomAD
CA398387801 rs1174475888	138	E>Q		No	ClinGen gnomAD
CA8465720 rs753438569	140	V>M		No	ClinGen ExAC gnomAD
CA398387781 rs1471671009	141	E>K		No	ClinGen gnomAD
rs766008745 CA8465719	142	R>*		No	ClinGen ExAC TOPMed gnomAD
rs760221349 CA8465718	142	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773002993 CA8465717	143	F>C		No	ClinGen ExAC gnomAD
COSM1520867 rs1255191357 CA398387765	143	F>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM3795387 CA398387762 rs1318633969	144	R>Q	urinary_tract Variant assessed as Somatic; 4.632e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA8465716 rs372096791	144	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs201929229 CA398387731	147	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465688 rs201929229	147	W>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	148	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs947575752 CA289121780	151	Y>C		No	ClinGen Ensembl
TCGA novel	152	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8465686 rs760811240	152	R>S		No	ClinGen ExAC gnomAD
CA8465685 rs773245847	153	P>H		No	ClinGen ExAC gnomAD
CA398387686 rs1248404805	153	P>S		No	ClinGen gnomAD
CA398387670 rs1254835667	155	S>A		No	ClinGen TOPMed gnomAD
CA398387672 rs1254835667	155	S>P		No	ClinGen TOPMed gnomAD
CA398387658 rs1209870349	156	V>G		No	ClinGen gnomAD
CA398387643 rs1355042976	158	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1263258224 CA398387633	159	I>T		No	ClinGen gnomAD
CA8465683 rs201225284	160	H>P		No	ClinGen ExAC gnomAD
rs1342521060 CA398387625	160	H>Q		No	ClinGen gnomAD
CA289121739 rs768335542	162	P>R		No	ClinGen Ensembl
CA398387594 rs1424111191	165	H>R		No	ClinGen gnomAD
rs748342765 CA8465682	165	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8465681 rs768338852	167	C>G		No	ClinGen ExAC gnomAD
rs768338852 CA8465680	167	C>R		No	ClinGen ExAC gnomAD
CA398387578 rs1480883539	167	C>S		No	ClinGen TOPMed
CA8465679 rs749032245	169	A>T		No	ClinGen ExAC gnomAD
rs780198713 CA8465678	171	D>G		No	ClinGen ExAC TOPMed gnomAD
rs756113212 CA8465676	173	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1025855176 CA289121681	174	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1460235584 CA398387495	175	E>A		No	ClinGen TOPMed
CA8465673 rs756740370	175	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8465675 rs746509784	175	E>K		No	ClinGen ExAC TOPMed gnomAD
rs746509784 CA398387500	175	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs867007955 CA289121657	179	E>K		No	ClinGen gnomAD
CA398387428 rs867007955	179	E>Q		No	ClinGen gnomAD
rs1597729175 CA398387379	181	E>K		No	ClinGen Ensembl
rs763747751 CA398387352	182	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763747751 CA8465669	182	E>Q		No	ClinGen ExAC gnomAD
rs1273495653 CA398387322	183	S>G		No	ClinGen gnomAD
CA398387310 rs1226598838	183	S>N		No	ClinGen gnomAD
rs1213105008 CA398387272	185	P>S		No	ClinGen gnomAD
CA8465667 rs759956496	186	P>A		No	ClinGen ExAC TOPMed gnomAD
CA398387250 rs754198104	186	P>H		No	ClinGen ExAC gnomAD
rs754198104 CA8465666	186	P>L		No	ClinGen ExAC gnomAD
CA398387235 rs1597729069	187	I>T		No	ClinGen Ensembl
rs1370140606 CA398387222	188	P>L		No	ClinGen TOPMed gnomAD
rs1410536539 CA398387225	188	P>S		No	ClinGen gnomAD
TCGA novel	188	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772073223 CA8465662	190	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs772073223 CA8465663	190	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs761884631 CA8465661	190	Q>H		No	ClinGen ExAC gnomAD
rs1249525508 CA398387198	190	Q>R		No	ClinGen TOPMed
rs1597728996 CA398387177	191	V>G		No	ClinGen Ensembl
rs573386518 CA8465660	191	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1173016727 CA398387152	193	P>S		No	ClinGen gnomAD
CA8465657 rs543135538	194	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465658 rs199919141	194	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745819940 CA8465655	196	A>T		No	ClinGen ExAC TOPMed gnomAD
CA398387078 rs1279743877	198	P>S		No	ClinGen gnomAD
rs1567712254 CA398387041	200	L>V		No	ClinGen Ensembl
CA398387021 rs1343424201	201	G>A		No	ClinGen gnomAD
RCV000969679 CA8465654 rs114236344	201	G>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8465653 rs140256102	202	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746518553 CA8465652	203	S>T		No	ClinGen ExAC gnomAD
rs1320663915 CA398386956	205	A>V		No	ClinGen gnomAD
CA398386944 rs1567712184	206	T>I		No	ClinGen Ensembl
CA8465650 rs371202222	207	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs754251318 CA8465649	208	T>I		No	ClinGen ExAC TOPMed gnomAD
CA398386905 rs1334543297	209	P>S		No	ClinGen gnomAD
CA398386850 rs1435418005	210	D>E		No	ClinGen TOPMed
rs1457258987 CA398386815	212	T>I		No	ClinGen gnomAD
rs1042222293 CA289121591	212	T>S		No	ClinGen TOPMed gnomAD
rs1179439709 CA398386806	213	A>T		No	ClinGen gnomAD
CA8465645 rs572743535	213	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774485004 CA8465642	217	I>M		No	ClinGen ExAC gnomAD
CA8465641 COSM3421365 rs182342785	219	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1329152439 CA398386693	219	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs931661503 CA289121562	221	E>D		No	ClinGen TOPMed gnomAD
rs536086715 CA8465639	224	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536086715 CA8465640	224	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1446936505 CA398386566	227	G>A		No	ClinGen TOPMed gnomAD
rs1283860119 CA398386572	227	G>S		No	ClinGen gnomAD
CA398386537 rs1338503006	228	Q>R		No	ClinGen gnomAD
CA8465637 rs745603315	230	S>R		No	ClinGen ExAC TOPMed gnomAD
rs776491153 CA8465636	231	K>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel CA398386420 rs746545857	234	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
rs573063962 CA8465633	237	K>E		No	ClinGen ExAC TOPMed gnomAD
CA398386341 rs1248517791	239	K>*		No	ClinGen gnomAD
TCGA novel	240	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8465631 rs771826469	241	E>K		No	ClinGen ExAC TOPMed gnomAD
CA398386279 rs771826469	241	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs747832617 CA8465630	242	K>R		No	ClinGen ExAC gnomAD
rs1393389167 CA398386234	243	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs756481029 CA8465628	243	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	243	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs942963678 CA289121532	244	K>E		No	ClinGen TOPMed
rs1077127 VAR_043476 CA289121525	245	D>A		No	ClinGen UniProt Ensembl dbSNP
CA8465627 rs750782908	246	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1567711743 CA398386149	247	E>K		No	ClinGen Ensembl
CA398386062 rs1597728466	251	E>G		No	ClinGen Ensembl
rs763085012 CA8465620	254	K>R		No	ClinGen ExAC gnomAD
rs373807531 CA8465619	255	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs778029551 CA8465618	256	K>T		No	ClinGen ExAC TOPMed gnomAD
CA398385905 rs1437915131	257	K>R		No	ClinGen gnomAD
rs151135532 CA8465617	258	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1349942474 CA398385875	258	K>R		No	ClinGen gnomAD
CA289121494 rs962554503	266	K>*		No	ClinGen Ensembl
CA8465614 rs770826343	266	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1388791659 CA398385672	267	K>E		No	ClinGen gnomAD
rs746993062 CA8465613	268	K>E		No	ClinGen ExAC TOPMed gnomAD
rs200114460 CA289121485	268	K>R		No	ClinGen 1000Genomes
CA8465611 rs773096567	269	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771577797 CA8465610	270	P>A		No	ClinGen ExAC gnomAD
CA8465609 rs747596303	270	P>L		No	ClinGen ExAC TOPMed gnomAD
rs770541517 CA8465607	272	K>D		No	ClinGen ExAC gnomAD
rs960609698 CA398385528	273	L>V		No	ClinGen TOPMed gnomAD
CA8465606 rs377031681	274	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA398385498 rs1471219963	275	P>S		No	ClinGen TOPMed
CA398385482 rs1220866614	276	S>Y		No	ClinGen TOPMed gnomAD
rs746253854 CA8465605	277	P>L		No	ClinGen ExAC TOPMed gnomAD
rs752138151 CA8465601	279	D>H		No	ClinGen ExAC gnomAD
rs758610329 CA8465599	280	V>M		No	ClinGen ExAC gnomAD
CA398385393 rs1369085020	282	R>*		No	ClinGen TOPMed gnomAD
rs200021121 CA8465597	282	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8465598 rs200021121	282	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8465594 COSM976984 rs143950518	286	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA289121410 rs533056293	291	R>G		No	ClinGen 1000Genomes
CA398385254 rs1165964731	291	R>S		No	ClinGen gnomAD
rs766230452 CA8465593	292	M>I		No	ClinGen ExAC gnomAD
rs760322267 COSM265739 CA8465592	294	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA398385209 rs1243295554	294	E>V		No	ClinGen Ensembl
CA398385193 rs1567711258	295	S>C		No	ClinGen Ensembl
rs1597728008 CA398385188	296	S>G		No	ClinGen Ensembl
CA289121407 rs893272296	296	S>I		No	ClinGen gnomAD
CA398385159 rs1249369733	297	P>L		No	ClinGen gnomAD
rs751617318 CA289121406	298	E>Q		No	ClinGen Ensembl
CA398385126 rs1212036139	299	S>G		No	ClinGen gnomAD
CA8465591 rs773145372	299	S>I		No	ClinGen ExAC gnomAD
CA398385105 rs771980693	300	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8465589 rs201073389	300	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771980693 CA8465590	300	R>W		No	ClinGen ExAC TOPMed gnomAD
CA398385065 rs1288498781	302	E>K		No	ClinGen gnomAD
rs1408836926 CA398385021	303	L>R		No	ClinGen TOPMed gnomAD
CA289121399 rs200833418	304	E>D		No	ClinGen Ensembl
CA398385015 rs547305035	304	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465588 rs547305035	304	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465586 rs748991687	306	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1183149668 CA398384936	307	D>N		No	ClinGen TOPMed
CA398384886 rs1174591459	309	Y>C		No	ClinGen gnomAD
CA289121396 rs369735310	309	Y>N		No	ClinGen ESP
rs779531231 CA8465585	310	N>S		No	ClinGen ExAC TOPMed gnomAD
CA8465584 rs529027052	311	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	312	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201634767 CA8465582	312	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398384847 rs1258559975	312	R>Q		No	ClinGen TOPMed gnomAD
COSM183619 rs201634767 CA8465581	312	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA398384821 rs1567711029	313	G>E		No	ClinGen Ensembl
rs1213052374 CA398384777	315	G>E		No	ClinGen Ensembl
CA8465579 rs752873252	318	S>P		No	ClinGen ExAC gnomAD
rs779160916 CA8465578	318	S>Y		No	ClinGen ExAC gnomAD
CA398384703 rs1331230083	319	S>N		No	ClinGen TOPMed gnomAD
rs369557485 CA398384699	319	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8465577 rs754976909	319	S>R		No	ClinGen ExAC gnomAD
VAR_043477 CA8465575 rs3744637	320	E>K		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs372496544 CA289121362	321	D>Y		No	ClinGen Ensembl
CA8465572 rs199835822	322	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750211068 CA8465573	322	I>V		No	ClinGen ExAC gnomAD
CA8465571 rs761712471	324	E>Q		No	ClinGen ExAC gnomAD
rs774223943 CA8465570	326	S>L		No	ClinGen ExAC gnomAD
CA8465568 rs200057429	327	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1455741312 CA398384540	328	P>S		No	ClinGen gnomAD
CA8465565 rs747419432	329	R>K		No	ClinGen ExAC TOPMed gnomAD
CA398384523 rs1196927523	329	R>S		No	ClinGen TOPMed
rs773690375 CA8465564	330	K>E		No	ClinGen ExAC gnomAD
rs1255216380 CA398384510	330	K>R		No	ClinGen gnomAD
rs1248597964 CA398384489	331	R>S		No	ClinGen gnomAD
CA8465562 rs748700857	331	R>T		No	ClinGen ExAC gnomAD
CA398384487 rs79223253	332	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8465561 rs79223253	332	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755100786 CA8465560	333	N>H		No	ClinGen ExAC TOPMed gnomAD
CA8465559 rs573823632	335	V>I		No	ClinGen ExAC TOPMed gnomAD
rs181428051 CA8465558	337	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs372361291 CA8465557	338	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1237317109 CA398384362	340	T>A		No	ClinGen Ensembl
CA398384307 rs1597727472	343	K>N		No	ClinGen Ensembl
rs767322592 CA8465554	346	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs767322592 CA398384279	346	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs757005530 CA398384231	349	K>R		No	ClinGen ExAC gnomAD
rs757005530 CA8465552	349	K>T		No	ClinGen ExAC gnomAD
rs751501990 CA8465551	350	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1567710652 CA398384205	351	N>K		No	ClinGen Ensembl
CA8465550 rs763878512	352	K>Q		No	ClinGen ExAC gnomAD
CA8465548 rs762593335	354	K>R		No	ClinGen ExAC TOPMed gnomAD
CA398384159 rs762593335	354	K>T		No	ClinGen ExAC TOPMed gnomAD
CA8465546 rs764989691	356	P>L		No	ClinGen ExAC gnomAD
CA8465547 rs774832594	356	P>S		No	ClinGen ExAC gnomAD
COSM417632 CA398384132 rs774832594	356	P>T	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	357	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8465545 rs188624178	357	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1209962688 CA398384072	360	N>K		No	ClinGen TOPMed gnomAD
CA289121302 rs200506796	363	L>I		No	ClinGen 1000Genomes
CA398384000 rs1289185764	363	L>P		No	ClinGen gnomAD
rs1343336254 CA398383951	365	S>W		No	ClinGen gnomAD

No associated diseases with Q8NCQ7

1 regional properties for Q8NCQ7

Type	Name	Position	InterPro Accession
domain	Phospholipase A2 domain	55 - 133	IPR016090

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name	Definition
cyclin binding	Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
phospholipase A2 activity	Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.

2 GO annotations of biological process

Name	Definition
arachidonic acid secretion	The controlled release of arachidonic acid from a cell or a tissue.
phospholipid metabolic process	The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MWVRTTLTIE	RWTKEKTEPK	ARSWDEALSD	VNRLPSWERG	HLLAGVASST	DVSTFSEGGD
70	80	90	100	110	120
CKEPDKCCWR	HKQCTGHIIY	PFASDCVRHS	LHLHSVNHCN	CNSRLKDSSE	DSSSSRGAGP
130	140	150	160	170	180
TCSHVIESPC	FELTPEEEHV	ERFRYGWCKS	YRPVSVAVIH	HPLYHECGAD	DLNEEEEEEE
190	200	210	220	230	240
EESKPPIPTQ	VGPATASPDL	GTSMATGTPD	STAPITIWRS	ESPTGKGQGS	KVIKKVKKKK
250	260	270	280	290	300
EKEKDKEEMD	EKAKLKKKAK	KGQLTKKKSP	VKLEPSPPDV	SRSLSARQLA	RMSESSPESR
310	320	330	340	350	360
EELESEDSYN	GRGQGELSSE	DIVESSSPRK	RENTVQAKKT	GAKPSQARKV	NKRKSPPGSN

PNLS