AiPD: Autoinhibited Protein Database

Q8NA77

Gene name	TEX19
Protein name	Testis-expressed protein 19
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:400629
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-132 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

27-132 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NA77

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NA77-F1	Predicted				AlphaFoldDB

133 variants for Q8NA77

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs761018318 CA295189559	4	P>A		No	ClinGen Ensembl
rs371327683 CA8856379	4	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA295189573 rs900962762	6	S>G		No	ClinGen Ensembl
CA401587913 rs1245990387	6	S>R		No	ClinGen gnomAD
CA401587930 rs1338083277	7	M>I		No	ClinGen TOPMed gnomAD
CA8856381 rs757728929	7	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8856383 rs143841873	8	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs143841873 CA8856382	8	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs868177850 CA295189588	8	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs766491977 CA295189613	9	Y>*		No	ClinGen Ensembl
rs1599669527 CA401587974	10	E>D		No	ClinGen Ensembl
rs1485404930 CA401587959	10	E>K		No	ClinGen gnomAD
rs754747769 CA8856384	11	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1352979376 CA401588005	12	E>A		No	ClinGen gnomAD
CA8856386 rs138453353	15	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401588051 rs138453353	15	S>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146250166 CA8856389	19	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401588143 rs1304150565	21	W>*		No	ClinGen gnomAD
CA295189649 rs185078297	22	M>I		No	ClinGen 1000Genomes TOPMed gnomAD
rs1395764523 CA401588157	22	M>T		No	ClinGen TOPMed
rs141219054 CA8856391 CA8856390	23	Y>*		No	ClinGen ESP ExAC gnomAD
rs559085175 CA295189682	26	Q>R		No	ClinGen Ensembl
rs1318138374 CA401588243	27	H>Q		No	ClinGen gnomAD
TCGA novel	28	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375937908 CA8856397	34	C>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs150740969 CA8856395	34	C>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA8856398 rs367711836	35	F>S		No	ClinGen ESP ExAC gnomAD
CA401588345 rs1257967420	37	C>S		No	ClinGen gnomAD
rs1346035716 CA401588355	38	F>L		No	ClinGen gnomAD
rs768068418 CA8856399	40	A>P		No	ClinGen ExAC TOPMed gnomAD
CA401588389 rs768068418	40	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	40	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259349893 CA401588404	41	A>S		No	ClinGen gnomAD
CA401588411 rs1185108733	41	A>V		No	ClinGen Ensembl
rs559280155 CA295189784	44	D>A		No	ClinGen ExAC TOPMed gnomAD
CA8856403 rs559280155	44	D>G		No	ClinGen ExAC TOPMed gnomAD
rs747835900 CA8856404	47	D>E		No	ClinGen ExAC gnomAD
CA8856406 rs116114329	50	E>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401588557 rs1156477833	50	E>D		No	ClinGen gnomAD
CA8856407 rs777443933	52	E>D		No	ClinGen ExAC gnomAD
rs746814720 CA8856408	53	D>N		No	ClinGen ExAC TOPMed gnomAD
rs553772038 CA8856409	54	W>*		No	ClinGen 1000Genomes ExAC gnomAD
CA401588623 rs1599669625	55	E>K		No	ClinGen Ensembl
CA401588706 rs1370982897	59	W>*		No	ClinGen gnomAD
CA401588709 rs1385130699	60	D>N		No	ClinGen gnomAD
CA401588721 rs1331784175	61	P>R		No	ClinGen TOPMed gnomAD
TCGA novel	62	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1238536426 CA401588727	62	E>G		No	ClinGen gnomAD
CA401588731 rs1266481991	63	L>M		No	ClinGen gnomAD
CA401588743 rs1237394406	64	M>V		No	ClinGen TOPMed
CA401588778 rs1335076626	66	H>N		No	ClinGen TOPMed
CA8856412 rs769889679	66	H>Q		No	ClinGen ExAC gnomAD
rs775496340 CA8856413	67	T>A		No	ClinGen ExAC gnomAD
rs1467122406 CA401588819	69	A>T		No	ClinGen gnomAD
CA8856414 rs763172270	72	E>K		No	ClinGen ExAC TOPMed gnomAD
CA295189871 rs1024891723	73	Q>*		No	ClinGen Ensembl
rs1179154699 CA401588865	75	G>A		No	ClinGen gnomAD
CA401588866 rs1179154699	75	G>V		No	ClinGen gnomAD
CA401588868 rs1459153804	76	S>A		No	ClinGen gnomAD
CA401588870 rs1459153804	76	S>T		No	ClinGen gnomAD
CA401588902 rs1302721754	78	G>V		No	ClinGen TOPMed
rs1394348193 CA401588925	80	E>K		No	ClinGen gnomAD
CA8856419 rs750913647	82	S>N		No	ClinGen ExAC gnomAD
CA401588982 rs1390892071	83	W>C		No	ClinGen gnomAD
CA8856420 rs761225499	83	W>R		No	ClinGen ExAC TOPMed gnomAD
CA401588988 rs1286675254 CA401588989	84	G>R		No	ClinGen TOPMed gnomAD
CA8856421 rs764863513	84	G>V		No	ClinGen ExAC gnomAD
rs1453194833 CA401589016	86	S>G		No	ClinGen TOPMed
TCGA novel	86	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8856422 rs752196807	86	S>N		No	ClinGen ExAC
CA401589033 rs1228758354	87	P>S		No	ClinGen gnomAD
rs1319739886 CA401589079	90	P>H		No	ClinGen gnomAD
CA8856424 rs137989980	91	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8856425 rs777468964	92	Q>H		No	ClinGen ExAC gnomAD
CA8856426 rs147220016	93	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA295189935 rs371566517	94	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs371566517 CA8856428	94	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA295189953 rs375218867	98	W>*		No	ClinGen ESP
rs1417528607 CA401589199	99	G>E		No	ClinGen gnomAD
CA295189966 COSM1710911 rs140570015	99	G>R	skin [Cosmic]	No	ClinGen cosmic curated ESP
rs768822950 CA8856433	101	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8856436 rs772518786	103	L>P		No	ClinGen ExAC TOPMed gnomAD
CA401589248 rs1372613314	104	A>E		No	ClinGen gnomAD
rs368255921 CA8856437	108	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA295190020 rs952000817	113	A>T		No	ClinGen Ensembl
CA401589415 rs1306907568	114	G>V		No	ClinGen gnomAD
rs913848768 CA295190027	115	L>P		No	ClinGen TOPMed gnomAD
CA401589455 CA401589458 rs1276102321	116	D>E		No	ClinGen TOPMed gnomAD
rs113265042 CA8856441	117	P>A		No	ClinGen ExAC gnomAD
rs113265042 CA8856440	117	P>S		No	ClinGen ExAC gnomAD
rs751255303 CA8856444	118	H>Q		No	ClinGen ExAC gnomAD
CA8856443 rs763692160	118	H>Y		No	ClinGen ExAC gnomAD
CA401589548 rs1184019063	121	P>S		No	ClinGen gnomAD
CA8856445 rs199751552	125	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381668950 CA401589643	125	W>C		No	ClinGen TOPMed
rs1275880745 CA401589625	125	W>R		No	ClinGen TOPMed gnomAD
rs1403014449 CA401589652	126	P>S		No	ClinGen TOPMed
rs1599669794 CA401589678	127	Q>L		No	ClinGen Ensembl
CA401589688 rs1305037364	128	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	128	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781052597 CA8856446	128	E>V		No	ClinGen ExAC TOPMed gnomAD
CA8856449 rs779957295	130	V>A		No	ClinGen ExAC gnomAD
rs116293085 CA8856448	130	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8856447 rs116293085	130	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401589757 rs1479032497	131	P>L		No	ClinGen TOPMed
rs1449938959 CA401589788	133	G>D		No	ClinGen gnomAD
rs1445863837 CA401589832	135	G>D		No	ClinGen TOPMed
rs200970555 CA8856453	135	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA401589840 rs183087726	136	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA8856454 rs183087726	136	L>I		No	ClinGen 1000Genomes ExAC gnomAD
CA8856455 rs772130130	139	A>S		No	ClinGen ExAC TOPMed gnomAD
rs772130130 CA401589907	139	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8856456 rs142370714	139	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	140	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439503805 CA401589941	141	W>R		No	ClinGen TOPMed gnomAD
CA401589983 rs1319763517	143	Q>*		No	ClinGen TOPMed
CA401589996 rs1276048234	143	Q>H		No	ClinGen gnomAD
rs1276472282 CA401590013	144	G>A		No	ClinGen TOPMed
rs771614199 CA8856458	144	G>C		No	ClinGen ExAC gnomAD
rs555486603 RCV000957697	147	W>missing		No	ClinVar dbSNP
rs759919288 CA8856461	147	W>G		No	ClinGen ExAC gnomAD
CA401590061 rs759919288	147	W>R		No	ClinGen ExAC gnomAD
CA401590102 rs1187168976	149	F>L		No	ClinGen gnomAD
rs1450163917 CA401590164	152	L>I		No	ClinGen gnomAD
rs1172125146 CA401590178	153	L>H		No	ClinGen gnomAD
rs535694164 CA8856463	154	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1416340231 CA401590202	155	C>*		No	ClinGen gnomAD
rs933781675 CA401590254	158	W>*		No	ClinGen TOPMed
rs933781675 CA295190147	158	W>C		No	ClinGen TOPMed
CA8856465 rs767149161	159	P>S		No	ClinGen ExAC gnomAD
rs750280258 CA8856466	161	F>S		No	ClinGen ExAC TOPMed gnomAD
CA8856467 rs755883987	164	S>P		No	ClinGen ExAC gnomAD
CA401590351 rs1567854255	165	S>W		No	ClinGen Ensembl

No associated diseases with Q8NA77

No regional properties for Q8NA77

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8NA77

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm	Was initially reported to localize in the nucleus However, it was later shown to localize in cytoplasm only Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
piRNA binding	Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

7 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
male meiotic nuclear division	A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
negative regulation of transposition	Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites.
placenta development	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
reciprocal meiotic recombination	The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MCPPVSMRYE	EEGMSYLYAS	WMYQLQHGDQ	LSICFTCFKA	AFLDFKDLLE	SEDWEEDNWD
70	80	90	100	110	120
PELMEHTEAE	SEQEGSSGME	LSWGQSPGQP	VQGGSEAWGP	GTLAAAPEGL	EDAGLDPHFV
130	140	150	160
PTELWPQEAV	PLGLGLEDAD	WTQGLPWRFE	ELLTCSHWPS	FFPS