AiPD: Autoinhibited Protein Database

Q8N5I9

Gene name	NOPCHAP1
Protein name	NOP protein chaperone 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:121053
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

100-169 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

100-169 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8N5I9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N5I9-F1	Predicted				AlphaFoldDB

180 variants for Q8N5I9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs749580288	1	M>?	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs78938272 CA242596711	2	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs958676661 CA386352416	2	E>G		No	ClinGen TOPMed
CA386352414 rs1179246349	2	E>K		No	ClinGen gnomAD
CA242596704 rs958676661	2	E>V		No	ClinGen TOPMed
rs1452414826 CA386352418	3	V>I		No	ClinGen TOPMed gnomAD
CA6757077 rs368545818	4	H>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs771638970 CA386352427	4	H>L		No	ClinGen ExAC TOPMed gnomAD
CA6757078 rs771638970	4	H>R		No	ClinGen ExAC TOPMed gnomAD
rs368545818 CA386352424	4	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA386352431 rs1225201049	5	G>D		No	ClinGen gnomAD
CA6757081 rs12580271	5	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6757080 VAR_056833 rs12580271	5	G>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA386352436 rs1308394065	6	K>E		No	ClinGen TOPMed
CA242596734 CA386352440 rs776314525	6	K>N		No	ClinGen ExAC TOPMed gnomAD
rs374254858 CA6757084	7	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374254858 CA6757083	7	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1215149969 CA386352442	7	P>S		No	ClinGen gnomAD
rs1129593 CA386352446	8	K>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1129593 CA386352445	8	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6757086 rs1129593 VAR_060438	8	K>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA386352455 rs935241447	9	A>D		No	ClinGen gnomAD
CA386352452 rs1368139956	9	A>S		No	ClinGen TOPMed gnomAD
CA242596764 rs935241447	9	A>V		No	ClinGen gnomAD
CA6757089 rs371639910	10	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371639910 COSM3810843 CA6757088	10	S>N	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA386352460 rs1193344182	10	S>R		No	ClinGen gnomAD
CA6757087 rs371639910	10	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777900503 CA6757091	11	P>A		No	ClinGen ExAC TOPMed gnomAD
CA6757092 rs535539364	11	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA242596788 rs535539364	11	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386352462 rs777900503	11	P>S		No	ClinGen ExAC TOPMed gnomAD
rs777900503 CA6757090	11	P>T		No	ClinGen ExAC TOPMed gnomAD
CA386352481 rs1309858163	14	S>P		No	ClinGen gnomAD
CA386352491 rs1346481293	15	S>L		No	ClinGen gnomAD
CA6757094 rs746380021	16	P>L	Variant assessed as Somatic; 4.72e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386352492 rs1419889053	16	P>T		No	ClinGen gnomAD
rs374997946 CA6757096	17	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA386352497 rs1592746602	17	T>P		No	ClinGen Ensembl
rs746561893 CA6757099	18	R>Q		No	ClinGen ExAC
CA386352503 rs1372485617	18	R>W		No	ClinGen gnomAD
rs117368247 CA6757102	19	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs117368247 CA6757103	19	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6757104 rs201369478	19	D>V		No	ClinGen 1000Genomes ExAC
rs1355986071 CA386352524	22	G>R		No	ClinGen gnomAD
CA6757105 rs371351832	23	V>I		No	ClinGen ESP ExAC gnomAD
CA386352529 rs371351832	23	V>L		No	ClinGen ESP ExAC gnomAD
CA386352536 rs1345136814	24	P>A		No	ClinGen TOPMed
CA6757107 rs766374958	27	K>N		No	ClinGen ExAC
CA6757106 rs763003278	27	K>R		No	ClinGen ExAC TOPMed gnomAD
CA6757108 rs751516011	29	L>P		No	ClinGen ExAC gnomAD
rs1470032125 CA386352576	31	T>A		No	ClinGen gnomAD
CA386352584 rs1366246266	32	A>V		No	ClinGen TOPMed
rs764224128 CA6757110	34	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1410711100 CA386352615	37	R>G		No	ClinGen TOPMed
CA6757111 rs754078464	37	R>H		No	ClinGen ExAC TOPMed gnomAD
CA386352617 rs754078464	37	R>P		No	ClinGen ExAC TOPMed gnomAD
CA386352894 rs1260434167	39	G>D		No	ClinGen gnomAD
CA6757113 rs779264151	39	G>R		No	ClinGen ExAC gnomAD
CA386352897 rs553044327	40	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1240681412 CA386352900	40	I>T		No	ClinGen gnomAD
rs553044327 CA6757129	40	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386352909 rs765405252	41	W>*		No	ClinGen ExAC gnomAD
rs765405252 CA6757130	41	W>C		No	ClinGen ExAC gnomAD
rs1287594745 CA386352922	43	R>M		No	ClinGen TOPMed
CA6757131 rs369869604	43	R>W		No	ClinGen ESP ExAC TOPMed
CA386352937 rs1229862203	45	L>P		No	ClinGen TOPMed
TCGA novel	46	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386352940 rs1285075238	46	I>F		No	ClinGen TOPMed
rs752012117 CA6757135	50	P>L		No	ClinGen ExAC gnomAD
rs752012117 CA6757134	50	P>R		No	ClinGen ExAC gnomAD
CA242598184 rs187213332	50	P>S		No	ClinGen 1000Genomes gnomAD
CA386352987 rs1348793939	53	R>T		No	ClinGen TOPMed
CA386352997 rs1400090256	54	K>N		No	ClinGen TOPMed gnomAD
CA6757138 rs755650170	57	T>I		No	ClinGen ExAC gnomAD
rs1398436956 CA386353036	61	V>I		No	ClinGen gnomAD
rs748939881 CA386353042	62	R>G		No	ClinGen ExAC TOPMed gnomAD
rs770919118 CA6757141	62	R>Q		No	ClinGen ExAC gnomAD
rs748939881 CA6757140	62	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA242598236 rs201752109 COSM1729677	63	I>T	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed gnomAD
rs1347819210 CA386353052	64	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs745808467 CA6757143	65	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1283003969 CA386353069	65	R>T		No	ClinGen gnomAD
rs374019637 CA386353104	67	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757145 rs776606163	67	P>L		No	ClinGen ExAC gnomAD
CA6757144 rs374019637	67	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1349109962 CA386353635	68	L>*		No	ClinGen TOPMed
rs1160591371 CA386353651	70	D>E		No	ClinGen gnomAD
rs756914491 CA6757161	70	D>V		No	ClinGen ExAC gnomAD
rs1424316795 CA386353657	71	Q>H		No	ClinGen gnomAD
rs778597849 CA6757162	71	Q>P		No	ClinGen ExAC gnomAD
CA6757164 rs771733790	73	Q>R		No	ClinGen ExAC gnomAD
CA386353677 rs1241296847	74	T>I		No	ClinGen TOPMed
CA6757165 rs373550337	76	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757166 rs746944094	78	Q>R		No	ClinGen ExAC gnomAD
rs773217138 CA6757168	79	M>T		No	ClinGen ExAC TOPMed gnomAD
CA6757167 rs769865983	79	M>V		No	ClinGen ExAC TOPMed gnomAD
CA6757170 rs565928398	81	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6757169 rs377566774	81	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757172 rs759991708	83	N>D		No	ClinGen ExAC gnomAD
CA6757174 rs145611751	83	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6757173 rs145611751	83	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386353733 rs1565938719	84	E>A		No	ClinGen Ensembl
rs761199161 CA6757175	84	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs373230527 CA242600414	85	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753351037 CA6757177	88	K>R		No	ClinGen ExAC TOPMed gnomAD
CA242600424 rs549921928	90	M>I		No	ClinGen Ensembl
rs1467273417 CA386353776	90	M>T		No	ClinGen gnomAD
CA386353780 rs1213146909	91	A>T		No	ClinGen TOPMed gnomAD
rs757002789 CA6757178	91	A>V		No	ClinGen ExAC TOPMed gnomAD
CA242600434 rs191930196	93	A>V		No	ClinGen 1000Genomes gnomAD
CA6757179 rs778667970	95	P>L		No	ClinGen ExAC gnomAD
TCGA novel	95	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6757181 rs758280475	96	G>D		No	ClinGen ExAC TOPMed gnomAD
rs377084571 CA242600446	97	R>C		No	ClinGen ESP
CA6757182 rs199516315	97	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	97	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6757183 rs200931216	103	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA386353869 rs1347614516	105	G>W		No	ClinGen TOPMed
CA6757184 rs768529525	106	P>L		No	ClinGen ExAC gnomAD
rs777858752 CA386353881	107	H>D		No	ClinGen ExAC TOPMed gnomAD
rs777858752 CA6757185	107	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs749405652 CA6757186	109	K>T		No	ClinGen ExAC TOPMed gnomAD
CA6757187 rs368287596	110	V>G		No	ClinGen ESP ExAC gnomAD
rs999687757 CA242600511	111	I>V		No	ClinGen TOPMed gnomAD
rs746117924 CA6757207	116	A>S		No	ClinGen ExAC gnomAD
rs1257882494 CA386354129	118	F>S		No	ClinGen gnomAD
CA386354138 rs1490595824	119	E>A		No	ClinGen TOPMed
CA386354143 rs1401833748	120	M>L		No	ClinGen gnomAD
CA242602036 rs911291904	120	M>R		No	ClinGen Ensembl
CA6757209 rs371748784	122	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs776031032 CA6757210	122	Q>R		No	ClinGen ExAC gnomAD
CA6757211 rs747421151	123	S>L		No	ClinGen ExAC gnomAD
CA386354165 rs1479016857	123	S>P		No	ClinGen gnomAD
CA386354167 rs747421151	123	S>W		No	ClinGen ExAC gnomAD
rs777336739 CA6757213	128	V>L		No	ClinGen ExAC gnomAD
rs777336739 CA386354198	128	V>M		No	ClinGen ExAC gnomAD
rs1592748896 CA386354204	129	D>H		No	ClinGen Ensembl
CA6757215 rs764815193	130	S>C		No	ClinGen ExAC TOPMed gnomAD
CA386354212 rs764815193	130	S>G		No	ClinGen ExAC TOPMed gnomAD
CA386354223 rs1452519363	131	S>L		No	ClinGen TOPMed gnomAD
rs1295976440 CA386354226	132	E>K		No	ClinGen gnomAD
CA386354253 rs1222938914	135	S>L		No	ClinGen TOPMed
CA386354255 rs1362127730	136	Q>*		No	ClinGen gnomAD
CA6757217 rs374710696	137	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1204234999 CA386354270	138	S>G		No	ClinGen Ensembl
rs766056750 CA6757219	138	S>I		No	ClinGen ExAC gnomAD
CA6757218 rs766056750	138	S>T		No	ClinGen ExAC gnomAD
CA242602120 rs11554636	142	S>G		No	ClinGen Ensembl
CA386354312 rs1285365196	144	E>*		No	ClinGen TOPMed
CA6757220 rs367786401	144	E>V		No	ClinGen ESP ExAC TOPMed
rs138936935 CA6757221	145	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1303453153 CA386354330	147	D>N		No	ClinGen gnomAD
rs755952301 CA6757223	148	E>K		No	ClinGen ExAC TOPMed gnomAD
rs779076625 CA6757224	149	D>G		No	ClinGen ExAC TOPMed gnomAD
rs745896625 CA6757225	151	S>N		No	ClinGen ExAC gnomAD
CA386354368 rs1246541660	152	I>V		No	ClinGen gnomAD
rs376760830 CA242602152	153	P>S		No	ClinGen ESP
CA6757226 rs758473392	157	T>I		No	ClinGen ExAC gnomAD
CA6757228 rs747222960	158	I>T		No	ClinGen ExAC gnomAD
CA6757227 rs780475223	158	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs769146367 CA6757229	159	D>G		No	ClinGen ExAC gnomAD
rs1203090211 CA386354446	164	P>S		No	ClinGen gnomAD
rs369460633 CA6757231	165	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386354459 rs1302246468	166	S>P		No	ClinGen gnomAD
CA386354495 rs1430795723	171	G>D		No	ClinGen TOPMed
rs202087919 CA6757233	175	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1477281685 CA386354540	177	D>E		No	ClinGen TOPMed
rs184257841 CA6757234	178	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6757236 rs765859693	181	S>N		No	ClinGen ExAC
rs377159683 CA6757239	182	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757240 rs759124890	184	K>*		No	ClinGen ExAC gnomAD
rs759124890 CA242602207	184	K>E		No	ClinGen ExAC gnomAD
rs777032057	184	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777032057	185	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA6757241 rs767316407	185	K>T		No	ClinGen ExAC
rs369173579 CA242602213	186	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757242 rs369173579	186	K>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA386354598 rs369173579	186	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6757243 rs756111844	186	K>Y		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q8N5I9

No regional properties for Q8N5I9

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8N5I9

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
box C/D snoRNP complex binding	Binding to a box C/D snoRNP complex.

1 GO annotations of biological process

Name	Definition
box C/D snoRNP assembly	The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MEVHGKPKAS	PSCSSPTRDS	SGVPVSKELL	TAGSDGRGGI	WDRLLINSQP	KSRKTSTLQT
70	80	90	100	110	120
VRIERSPLLD	QVQTFLPQMA	RANEKLRKEM	AAAPPGRFNI	ENIDGPHSKV	IQMDVALFEM
130	140	150	160	170	180
NQSDSKEVDS	SEESSQDSSE	NSSESEDEDD	SIPSEVTIDN	IKLPNSEGGK	GKIEVLDSPA

SKKKK