AiPD: Autoinhibited Protein Database

Q8N1Q8

Gene name	THEM5 (ACOT15)
Protein name	Acyl-coenzyme A thioesterase THEM5
Names	Acyl-CoA thioesterase THEM5, Acyl-coenzyme A thioesterase 15, Thioesterase superfamily member 5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:284486
EC number	3.1.2.2: Thiolester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-73 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q8N1Q8

Entry ID	Method	Resolution	Chain	Position	Source
4AE7	X-ray	145 A	A	35-247	PDB
AF-Q8N1Q8-F1	Predicted				AlphaFoldDB

205 variants for Q8N1Q8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA341998787 rs1401329968	2	I>T		No	ClinGen TOPMed
CA1096442 rs754356775	4	R>G		No	ClinGen ExAC gnomAD
CA1096441 rs778320508	4	R>T		No	ClinGen ExAC gnomAD
rs756474422 CA1096440	5	C>R		No	ClinGen ExAC gnomAD
rs1280925934 CA341998743	5	C>W		No	ClinGen TOPMed
CA341998727 rs1490408010	6	F>L		No	ClinGen gnomAD
rs1216566866 CA341998705	8	V>L		No	ClinGen gnomAD
rs1355101534 CA341998688	9	A>V		No	ClinGen gnomAD
rs1330150225 CA341998677	10	A>V		No	ClinGen TOPMed
rs765871696 CA1096435	13	G>A		No	ClinGen ExAC
rs200511087 CA30489013	13	G>C		No	ClinGen TOPMed
rs200511087 CA30489020	13	G>R		No	ClinGen TOPMed
rs1339604899 CA341998622	14	H>R		No	ClinGen gnomAD
CA1096434 rs762511855	15	H>N		No	ClinGen ExAC gnomAD
rs773075332 CA1096433	16	R>S		No	ClinGen ExAC gnomAD
CA30488993 rs914570893	17	G>D		No	ClinGen Ensembl
rs761734311 CA1096431	18	L>F		No	ClinGen ExAC gnomAD
CA341998571 rs1286716575	18	L>H		No	ClinGen TOPMed
CA341998554 rs1218931464	20	E>Q		No	ClinGen TOPMed
rs772424639 CA341998533	21	A>D		No	ClinGen ExAC TOPMed gnomAD
CA1096430 rs776521336	21	A>T		No	ClinGen ExAC gnomAD
CA1096429 rs772424639	21	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1096428 rs370864082	23	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs368052106 CA1096426	23	R>H		No	ClinGen ESP
TCGA novel	24	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779178086 CA1096425	27	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1002042962 CA30488936	28	L>V		No	ClinGen TOPMed gnomAD
CA341998435 rs1480664343	29	N>K		No	ClinGen gnomAD
rs770961173 CA1096424	29	N>T		No	ClinGen ExAC gnomAD
TCGA novel	30	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs563588343 CA30488913	31	A>D		No	ClinGen Ensembl
rs749355211 CA1096423	31	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1196778554 CA341998411	32	S>T		No	ClinGen gnomAD
rs1381508585 CA341998374	34	F>L		No	ClinGen TOPMed
rs1572063630 CA341998351	36	S>F		No	ClinGen Ensembl
rs1420912776 CA341998340	37	S>F		No	ClinGen TOPMed
rs368050120 CA30488906	38	T>A		No	ClinGen ESP TOPMed gnomAD
rs1197055370 CA341998313	39	D>E		No	ClinGen TOPMed gnomAD
rs778172770 CA1096422	40	S>A		No	ClinGen ExAC gnomAD
rs892146575 CA30488878	41	M>I		No	ClinGen TOPMed gnomAD
rs61754919 CA341998295	41	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61754919 CA1096421	41	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748722568 CA1096400	43	S>L		No	ClinGen ExAC TOPMed gnomAD
CA1096399 rs781656232	46	L>S		No	ClinGen ExAC gnomAD
rs1254745598 CA341997792	47	P>T		No	ClinGen gnomAD
rs1183673008 CA341997784	48	E>K		No	ClinGen gnomAD
CA341997723 rs1196692582	52	L>M		No	ClinGen gnomAD
rs755385477 CA1096398	53	K>*		No	ClinGen ExAC TOPMed gnomAD
rs16833597 VAR_031764 CA1096397	55	Y>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1286811532 CA341997668	56	A>T		No	ClinGen gnomAD
CA341997651 rs1203575803	57	L>F		No	ClinGen gnomAD
rs758022985 CA1096395	57	L>P		No	ClinGen ExAC gnomAD
rs749918467 CA1096394	58	P>H		No	ClinGen ExAC gnomAD
CA341997635 rs150019062	59	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1384896046 CA341997629	59	N>S		No	ClinGen gnomAD
CA1096393 rs150019062	59	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs199774275 CA30487896	60	A>V		No	ClinGen 1000Genomes gnomAD
rs1052365564 CA30487887	61	S>G		No	ClinGen TOPMed
rs764088633 CA1096390	62	W>*		No	ClinGen ExAC TOPMed gnomAD
CA1096391 rs753871648	62	W>R		No	ClinGen ExAC gnomAD
CA341997593 rs764088633	62	W>S		No	ClinGen ExAC TOPMed gnomAD
rs1320084272 CA341997559	64	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	64	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766522055 CA1096387	65	D>A		No	ClinGen ExAC gnomAD
TCGA novel	65	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1096386 rs763169938	66	M>T		No	ClinGen ExAC gnomAD
rs113162117 COSM108143 CA1096385	68	S>N	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341997486 rs1371834537	69	L>P		No	ClinGen gnomAD
COSM895948 CA341997452 rs1244127502	72	E>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1400261611 CA341997438	73	F>L		No	ClinGen gnomAD
rs200585408 CA1096382	75	E>G		No	ClinGen ExAC gnomAD
CA1096381 rs769116249	76	K>N		No	ClinGen ExAC gnomAD
CA341997360 rs747359317	78	K>N		No	ClinGen ExAC TOPMed gnomAD
CA341997333 rs775909654	80	S>R		No	ClinGen ExAC TOPMed gnomAD
CA1096377 rs558957960	81	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs558957960 CA1096378	81	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1096376 rs778682602	82	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756863692 CA1096375	86	P>S		No	ClinGen ExAC TOPMed gnomAD
rs753357280 CA1096374	91	N>K		No	ClinGen ExAC gnomAD
CA1096373 rs35299454	93	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	94	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1096370 rs752438289	96	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1096371 rs376299585	96	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1096369 rs767415506	97	G>E		No	ClinGen ExAC gnomAD
rs965131429 CA30487697	98	L>I		No	ClinGen Ensembl
rs1176660509 CA341997080	102	S>P		No	ClinGen TOPMed gnomAD
CA1096368 rs370211306	106	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773472992 CA1096367	108	S>P		No	ClinGen ExAC TOPMed gnomAD
CA341997021 rs773472992	108	S>T		No	ClinGen ExAC TOPMed gnomAD
CA341997013 rs1201803421	109	D>N		No	ClinGen gnomAD
rs765469169 CA1096349	110	K>I		No	ClinGen ExAC gnomAD
rs765469169 CA30486875	110	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341996899 rs765469169	110	K>T		No	ClinGen ExAC gnomAD
rs761969999 CA1096348	111	G>D		No	ClinGen ExAC gnomAD
CA341996862 rs1306496967	113	C>Y		No	ClinGen gnomAD
CA30486857 rs929391198	114	R>C		No	ClinGen TOPMed gnomAD
CA1096347 COSM1334049 rs753923316	114	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs753923316 CA341996846	114	R>L		No	ClinGen ExAC TOPMed gnomAD
rs374861686 CA1096346	115	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA341996842 rs374861686	115	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1279128602 CA341996781	119	C>Y		No	ClinGen TOPMed
rs1160041399 CA341996740	122	V>M		No	ClinGen gnomAD
CA1096342 rs569926934	123	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs561316028 CA1096340	129	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341996647 rs1178112249	129	Y>H		No	ClinGen gnomAD
CA341996614 rs1243742058	131	I>T		No	ClinGen TOPMed gnomAD
rs1183344622 CA341996566	134	Q>H		No	ClinGen gnomAD
rs770712505 CA1096339	135	P>A		No	ClinGen ExAC TOPMed gnomAD
CA1096338 rs749015504	137	Q>K		No	ClinGen ExAC gnomAD
CA1096337 rs777555505	137	Q>P		No	ClinGen ExAC gnomAD
CA1096336 rs769395039	139	K>M		No	ClinGen ExAC gnomAD
CA1096333 rs200369753	140	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1416730478 CA341996504	140	S>P		No	ClinGen TOPMed
CA1096331 rs754826520	141	V>I		No	ClinGen ExAC gnomAD
rs751371464 CA1096330	143	L>R		No	ClinGen ExAC TOPMed gnomAD
CA1096328 rs758188940	144	F>L		No	ClinGen ExAC gnomAD
CA1096329 rs548003244	144	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199737525 CA30486610	145	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA gnomAD
CA341996475 rs199737525	145	Q>E		No	ClinGen 1000Genomes gnomAD
CA341996467 rs1425421915	146	P>A		No	ClinGen TOPMed gnomAD
rs995356648 CA30486609	146	P>L		No	ClinGen TOPMed
CA341996466 rs1425421915	146	P>S		No	ClinGen TOPMed gnomAD
rs754104368 CA1096327	147	G>S		No	ClinGen ExAC gnomAD
rs756246769 CA1096325	148	S>F		No	ClinGen ExAC gnomAD
rs1394268152 CA341996446	149	Y>*		No	ClinGen TOPMed
rs1461794961 CA341996451	149	Y>H		No	ClinGen TOPMed
rs752667405 CA1096323	150	L>P		No	ClinGen ExAC gnomAD
rs768080665 CA1096322	151	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA30486528 rs1025110658	153	P>H		No	ClinGen Ensembl
rs200336579 CA1096320	153	P>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	154	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1336475178 CA341996423	154	P>S		No	ClinGen TOPMed
rs766908095 CA1096319	155	G>A		No	ClinGen ExAC gnomAD
rs755094159 CA1096303	156	F>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1096301 rs763444720	158	H>Q		No	ClinGen ExAC gnomAD
CA1096302 rs752161833	158	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs543970440 CA341996347	159	G>C		No	ClinGen ExAC TOPMed gnomAD
rs543970440 CA1096299	159	G>S		No	ClinGen ExAC TOPMed gnomAD
rs991003578 CA30484199	160	G>E		No	ClinGen TOPMed
rs541469397 CA1096297	160	G>R		No	ClinGen ExAC TOPMed gnomAD
rs776346507 CA1096296	161	S>A		No	ClinGen ExAC gnomAD
CA341996312 rs1347639345	162	L>P		No	ClinGen gnomAD
rs768216646 CA1096295	163	A>E		No	ClinGen ExAC gnomAD
rs1299272134 CA341996308	163	A>T		No	ClinGen gnomAD
rs1389890173 CA341996284	165	M>V		No	ClinGen TOPMed gnomAD
rs1572060338 CA341996261	166	M>K		No	ClinGen Ensembl
CA1096292 rs199853939	168	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1096293 rs199853939	168	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1096291 rs745686412	169	T>N		No	ClinGen ExAC gnomAD
CA1096290 rs778504049	175	F>L		No	ClinGen ExAC gnomAD
rs748377229 CA1096288	178	G>A		No	ClinGen ExAC gnomAD
CA1096289 rs370580520	178	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1181002645 CA341996096	179	E>G		No	ClinGen gnomAD
TCGA novel	180	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751651455 CA1096285	183	T>P		No	ClinGen ExAC gnomAD
rs1347397398 CA341996034	184	L>P		No	ClinGen gnomAD
CA1096284 rs780730775	185	S>R		No	ClinGen ExAC gnomAD
CA1096283 rs758921203	186	L>H		No	ClinGen ExAC gnomAD
rs1032415035 CA30484128	189	R>K		No	ClinGen TOPMed
CA1096282 rs750807190	189	R>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1096281 rs765591109	192	N>H		No	ClinGen ExAC
CA1096256 rs767071162	195	P>S		No	ClinGen ExAC gnomAD
CA1096255 COSM895945 rs759063830	196	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341995862 rs6587625	197	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs6587625 VAR_031765 CA1096254	197	D>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs6587625 CA341995863	197	D>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	198	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1096253 rs747232182	199	L>P		No	ClinGen ExAC gnomAD
CA341995840 rs1292625369	200	V>G		No	ClinGen gnomAD
rs1228743927 CA341995830	201	V>A		No	ClinGen gnomAD
rs1558180060 CA341995837	201	V>I		No	ClinGen Ensembl
rs1558180060 CA341995834	201	V>L		No	ClinGen Ensembl
CA1096252 rs762679704	202	M>T		No	ClinGen ExAC gnomAD
CA1096250 rs200948412	204	V>I		No	ClinGen ExAC TOPMed gnomAD
rs200948412 CA1096249	204	V>L		No	ClinGen ExAC TOPMed gnomAD
rs6587624 CA1096246 VAR_031766	206	L>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1096244 rs138448945	209	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs138448945 CA1096243	209	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs961405016 CA30483729	209	I>V		No	ClinGen gnomAD
CA1096242 rs749655007	211	D>E		No	ClinGen ExAC gnomAD
rs1431233015 CA341995628	215	Y>*		No	ClinGen TOPMed
CA1096241 rs778176144	215	Y>C		No	ClinGen ExAC gnomAD
CA341995616 rs1475973322	216	M>I		No	ClinGen gnomAD
CA341995621 rs1558180026	216	M>T		No	ClinGen Ensembl
rs756456239 CA1096240	217	S>T		No	ClinGen ExAC gnomAD
CA1096239 COSM1229158 rs368281552	220	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1269621826 CA341995555	221	H>R		No	ClinGen gnomAD
rs560208573 CA1096235 CA1096236	224	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1096237 rs754477453	224	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341995465 rs1284263801	228	V>I		No	ClinGen TOPMed
rs1572059833 CA341995445	229	Y>C		No	ClinGen Ensembl
rs1227053989 CA341995453	229	Y>H		No	ClinGen TOPMed
rs192983700 CA1096231	230	A>D		No	ClinGen 1000Genomes ExAC gnomAD
CA341995415 rs1438035849	231	K>N		No	ClinGen TOPMed gnomAD
CA341995427 rs1274920863	231	K>Q		No	ClinGen gnomAD
CA1096230 rs761681491	234	G>C		No	ClinGen ExAC TOPMed gnomAD
CA341995387 rs761681491	234	G>S		No	ClinGen ExAC TOPMed gnomAD
rs771090386 CA1096207	238	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs749334518 CA1096206	241	L>V		No	ClinGen ExAC gnomAD
CA341995292 rs1310085837	244	E>K		No	ClinGen gnomAD
CA341995280 rs1558179810	245	S>C		No	ClinGen Ensembl
rs375477086 CA1096205	246	P>L		No	ClinGen ESP ExAC TOPMed
CA1096204 rs770237043	247	Q>R		No	ClinGen ExAC gnomAD
CA1096203 rs748526233	248	Q>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q8N1Q8

1 regional properties for Q8N1Q8

Type	Name	Position	InterPro Accession
domain	Thioesterase domain	155 - 228	IPR006683

Functions

		Description
EC Number	3.1.2.2	Thiolester hydrolases
Subcellular Localization	Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name	Definition
myristoyl-CoA hydrolase activity	Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A.
palmitoyl-CoA hydrolase activity	Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.

3 GO annotations of biological process

Name	Definition
cardiolipin acyl-chain remodeling	Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.
fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
long-chain fatty-acyl-CoA metabolic process	The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MIRRCFQVAA	RLGHHRGLLE	APRILPRLNP	ASAFGSSTDS	MFSRFLPEKT	DLKDYALPNA
70	80	90	100	110	120
SWCSDMLSLY	QEFLEKTKSS	GWIKLPSFKS	NRDHIRGLKL	PSGLAVSSDK	GDCRIFTRCI
130	140	150	160	170	180
QVEGQGFEYV	IFFQPTQKKS	VCLFQPGSYL	EGPPGFAHGG	SLAAMMDETF	SKTAFLAGEG
190	200	210	220	230	240
LFTLSLNIRF	KNLIPVDSLV	VMDVELDKIE	DQKLYMSCIA	HSRDQQTVYA	KSSGVFLQLQ

LEEESPQ