Q8MZC4
Gene name |
CLS (CG4774) |
Protein name |
Probable cardiolipin synthase (CMP-forming) |
Names |
CLS |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4774 |
EC number |
2.7.8.41: Transferases for other substituted phosphate groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8MZC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8MZC4-F1 | Predicted | AlphaFoldDB |
No variants for Q8MZC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8MZC4 | |||||
No associated diseases with Q8MZC4
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.8.41 | Transferases for other substituted phosphate groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cardiolipin synthase (CMP-forming) | Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol. |
| cardiolipin synthase activity | Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP biosynthetic process | The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
| glycerophospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. |
| mitochondrial membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLPAIIFRQV | QRPLHHGAAT | LEHVLGVGGS | SFVNCLNRYA | AATGFIRISF | LDIKRRRNYE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LARLRLYADE | KKQSLHLRTL | QGRHLLQGVI | ERKNFLVDDI | REARHKVQER | VREKIDEIRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERENIMTIPN | MLTISRAVLS | PYIGYVIVQG | DFTLGMSLLA | FAGITDLLDG | QIARRWPSQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKFGSFLDPM | ADKLLMGSLV | ISLCYTDLLP | MWLMGIVVFR | DVFLLGAGFV | IRYISLPPPK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFSRYFDATH | VTAQLEPTLL | SKINTGVQLA | TIGLSLGAPI | WNYLDHPALQ | GLWYLTGLTT |
| 310 | 320 | ||||
| AATALSYVMN | RHNTFKIIQK | KT |