Q8MY86
Gene name |
FGFR1 |
Protein name |
Fibroblast growth factor receptor 1 |
Names |
DjFgfr1, FGFR-1, DjPTK3 |
Species |
Dugesia japonica (Planarian) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
706-729 (Activation loop from InterPro)
Target domain |
551-822 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8MY86
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8MY86-F1 | Predicted | AlphaFoldDB |
No variants for Q8MY86
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8MY86 | |||||
No associated diseases with Q8MY86
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGLFFLLSE | LLILLGKINS | VSKKSLCHPE | LFKIDNKLNW | RTSEEMVLTC | KAVVNEKCKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKLQMRWYKD | NELLGKKIER | GLKMKYRYRK | KLKLNDSGNY | TCFVFNKNGN | SSVFFLINVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKENFHVNEN | KILDGSEISN | NTLYLHPEMG | MENYHVIPND | EIVMQCRFFS | PISINLTVSW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YQHSCDSNYH | NAQLLVKDSK | FNISSNKESC | QSYLSHIPLD | SICLYSWLRF | IATSDDQSCI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TCLIESDNNS | IEKTKFTFTV | LVDAGHRPHL | TFAPSSTVCQ | GSNFTMKCET | NVPRPILYIY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLDPSFNIEN | PIIHLSNSTL | FVNNYNEDSK | RSSQSAEVLI | KSMDFNYSGR | YLCSLAELPL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FEIMHLSVIK | CSNNFFMNSV | PLSIFLVIGF | FVAIILLSLI | IYCFFLQYKN | AVDSRKHFSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RKTVIVEYES | PIYKSFINGT | KNFKTDVLHT | NSLLPDSNPL | LPPIIKIKPI | KRLSQFRDGN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YGEQLPSTST | DRTRLESTRH | SQLENEVFEC | GSGNNSLSLK | YGLRKSSSFE | FFSLYEFPCD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AKWEFPREKL | KITNKKLGEG | AFGMVYEGIA | NDIGNRSNPI | KVAVKMMRDD | FSDSNVHDFV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KEMEIMKHIG | RHPNVIQLLG | LCTQKGPLRV | IVELAPYGNL | RDFVRAKNKK | YSKSKKIIGN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FTSSILCTYS | LQIARGMTYL | ASRSVVHRDL | SARNILVGEH | FEMKIADFGL | TRIVDYYYRK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KTDGILPVKW | MAPEALLEKK | YTTKSDVWSY | GILLWEIFTL | GDSPYSAILP | EKVVDLIRKG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FQNPKPELAN | FEIYRLMQHC | WSLSSENRPN | FFEIVEILID | IIQRIDDEPE | ENIYHSELNY |
| 850 | |||||
| LKMESDYLEP | KCLV |