Q8MP20

PR
Gene name
thrS2 (DDB_G0274545)
Protein name
Probable threonine--tRNA ligase 2, cytoplasmic
Names
Threonyl-tRNA synthetase, ThrRS
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0274545
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

512-586 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8MP20

Entry ID Method Resolution Chain Position Source
AF-Q8MP20-F1 Predicted AlphaFoldDB

No variants for Q8MP20

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8MP20

No associated diseases with Q8MP20

6 regional properties for Q8MP20

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 363 - 586 IPR002314
domain TGS 38 - 100 IPR004095
domain Anticodon-binding 599 - 691 IPR004154
domain Aminoacyl-tRNA synthetase, class II 307 - 592 IPR006195
domain Threonine-tRNA ligase catalytic core domain 281 - 597 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 597 - 691 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFLKLTKSI QKINNFNNNK INLINKYFST TNINNSGGGG NIKLNDGRIF KFEDKQTPLT
70 80 90 100 110 120
IANKINKTIG KQSILSRLNG NKLISMKEII EMSGKDYNIE FLNFEEHSDA RICFWNSSSL
130 140 150 160 170 180
VLARATMEYF KNENKEIELI NFGHLVNPQT ADNINQGTFY IDIFFKDKNQ TIKDNDINKI
190 200 210 220 230 240
KKIMEYIVKR NDKFEILKND QQDQDQDQEE SFIKFGEFKF KNNFLTIDSS NSIVSLDLIK
250 260 270 280 290 300
NSSVVGPNKE YSELQRIVGI SFPSKDQMNN WVEIQKIAAL RDHRVIGKDQ ELFFFHPFSP
310 320 330 340 350 360
GSCFFLPHGT KIYNKLLQFL RLEYRKRGYQ EVISPNIYNQ KLWETSGHWD NYKDNMFSFE
370 380 390 400 410 420
CDHTQYSLKP MNCPGHCLMY AHRARSYKEL PMRIADFGVL HRNETHGSLS GLTRVRRFQQ
430 440 450 460 470 480
DDAHIFCTPD MIREEIKQCL DFMKYVYTIF NFTFHLELST RPDSYLGELS VWEKAETSLS
490 500 510 520 530 540
QVLTEFCGDK WTINHGDGAF YGPKIDIHLK DANGKNHQCA TIQLDFQLPI RFNLEYSGGL
550 560 570 580 590 600
NNNNNNNNNN EEINDNNNNN SLNRPVMIHR ALFGSVERMM AILMEHTAGK WPFWLSPRQC
610 620 630 640 650 660
IVIPVSNKFN QFAQEIQSKI NLAGYDVDVD LNDSKLLSKK IREATVSQYN YIIVVGQEEI
670 680 690
DTNILNVRKR DLPEDNKQVK LSLNDLFSEF KLNIEQFK