Q8MLZ3

PR
Gene name
pdeD (gbpA, pde5, DDB_G0274383)
Protein name
cGMP-dependent 3',5'-cGMP phosphodiesterase A
Names
Cyclic GMP-binding protein A, Phosphodiesterase 5, DdPDE5, Phosphodiesterase D
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0274383
EC number
3.1.4.35: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

97-264 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8MLZ3

Entry ID Method Resolution Chain Position Source
AF-Q8MLZ3-F1 Predicted AlphaFoldDB

No variants for Q8MLZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8MLZ3

No associated diseases with Q8MLZ3

6 regional properties for Q8MLZ3

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 4 - 78 IPR000089-1
domain Biotin/lipoyl attachment 122 - 196 IPR000089-2
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 326 - 552 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 28 - 57 IPR003016-1
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 146 - 175 IPR003016-2
domain Peripheral subunit-binding domain 250 - 287 IPR004167

Functions

Description
EC Number 3.1.4.35 Phosphoric diester hydrolases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.
cGMP binding Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
metal ion binding Binding to a metal ion.

10 GO annotations of biological process

Name Definition
aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
cGMP catabolic process The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate.
cGMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
negative regulation of actin filament polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of phosphatidylinositol 3-kinase signaling Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
positive regulation of myosin II filament assembly Any process that activates or increases the frequency, rate or extent of myosin II filament assembly.
protein localization to cell cortex A process in which a protein is transported to, or maintained in, the cell cortex.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMFSKRKSIR FNPEGDYTEL PRGGYVVPSK LGGIQFGVPP ETIKDSMALK IDVPTIYVFP
70 80 90 100 110 120
EELWDRKTGI NAAEAEFPAY FNYFILKRKV SFVCTKEQEQ RIRIVFQETL LGPPEFNTGI
130 140 150 160 170 180
IINSSSSTTD TSKTSPIKKQ TSSSSPPLSP QQQQPPPPLV KQPSQQQLEE LATMDTCHYH
190 200 210 220 230 240
HHHHHQEVND NDNNNNTTTN NNNIEILEQQ QQQQQQQQQQ QDEDSTDVDE EFQKEFSSTF
250 260 270 280 290 300
PRSEIPNLEK ECKYLRTFNS VDELFDFILF DDNGIAKLSD DVEIHFQEDQ SLFKVLQFEE
310 320 330 340 350 360
TGKGNKVQTL VATIPSKILF PDMINSISTI NDNKIFDPPT FGITIIGSSH GFDPKKSTTG
370 380 390 400 410 420
FVLWINKRGI MVDPPLNSSS FLQSQGVPTR MVDHIILTHC HADHDSGTFQ KLLEEYQITV
430 440 450 460 470 480
VTTPTILGSF LRKYGALSNL STDLLRRLFI FRPVMIGEPM IISGAEFRFF YTIHTIPTIS
490 500 510 520 530 540
FEVFYGGKSI FYSGDTCYDP NRIKDMNKRG IMKTSRMKFF LRPWNHTVVL HEAGVPPIHT
550 560 570 580 590 600
PVSVLRALPD EVKNRLYLVH ISEHTLPAGS GLKIAKEGVA HTLSLDVMKS SHSEAVDILK
610 620 630 640 650 660
LVESVDIFRS IPLTQACEIL QTATKRKYSQ GSVIIARDTE PDAFYVVASG VVCVNIGELK
670 680 690 700 710 720
KNLIVGDYFG EMSLVMGGLR SANVQAVTDV EVLSFNKEDF LSITRNSTES IQFITRLWEM
730 740 750 760 770 780
RNEKSWETMS LNSVFSRCTN SQKTAIQSIL VRELIKKDET LWCKGEEALF GCLVAEGSFV
790 800 810 820 830 840
FKEDDSLESF SQGSFLGDIN AMTTQPPSIH KTTVVAKEES VIYKVLSQDL IKFFSNNPGI
850 860
QLAFLDTIFV DALRDQVQQL VNSKLTY