Q8LFA9

PR
Gene name
At1g19340 (F18O14.6)
Protein name
Methyltransferase-like protein 2
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G19340
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q8LFA9

Entry ID Method Resolution Chain Position Source
7CV6 X-ray 301 A B 1-414 PDB
7CV7 X-ray 230 A A/B 1-414 PDB
7CV8 X-ray 237 A A 1-414 PDB
7CV9 X-ray 246 A A/C 1-414 PDB
7CVA X-ray 250 A A/B 1-414 PDB
7DPE X-ray 275 A A 1-414 PDB
AF-Q8LFA9-F1 Predicted AlphaFoldDB

37 variants for Q8LFA9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04602145 8 A>S No 1000Genomes
ENSVATH04602146 15 I>T No 1000Genomes
ENSVATH11531102 17 E>K No 1000Genomes
ENSVATH00032026 18 S>C No 1000Genomes
ENSVATH04602147 20 E>D No 1000Genomes
ENSVATH04602148 21 F>S No 1000Genomes
ENSVATH01070938 27 D>N No 1000Genomes
ENSVATH00032027 28 T>A No 1000Genomes
ENSVATH00032027 28 T>P No 1000Genomes
tmp_1_6684897_C_G 34 R>G No 1000Genomes
tmp_1_6684906_A_G 37 T>A No 1000Genomes
ENSVATH00032028 59 H>Q No 1000Genomes
ENSVATH04602149 74 N>I No 1000Genomes
ENSVATH11531103 103 E>K No 1000Genomes
ENSVATH04602150 104 S>T No 1000Genomes
ENSVATH13925475 108 E>K No 1000Genomes
ENSVATH11531104 128 S>N No 1000Genomes
tmp_1_6685246_C_A 150 P>H No 1000Genomes
ENSVATH04602155 195 S>Y No 1000Genomes
ENSVATH00032033 253 Q>L No 1000Genomes
ENSVATH00032033 253 Q>R No 1000Genomes
tmp_1_6686032_G_A 266 A>T No 1000Genomes
ENSVATH13925484 267 E>K No 1000Genomes
tmp_1_6686047_G_A 271 V>M No 1000Genomes
ENSVATH13925485 283 S>T No 1000Genomes
ENSVATH01070943 288 E>K No 1000Genomes
tmp_1_6686263_C_A 312 L>M No 1000Genomes
ENSVATH11531372 332 H>Y No 1000Genomes
tmp_1_6686330_C_G 334 T>S No 1000Genomes
ENSVATH04602164 337 A>V No 1000Genomes
ENSVATH04602165 338 G>A No 1000Genomes
tmp_1_6686467_C_G 351 N>K No 1000Genomes
ENSVATH04602168 376 P>L No 1000Genomes
ENSVATH13925490 380 P>R No 1000Genomes
ENSVATH04602169 383 C>S No 1000Genomes
ENSVATH00032034 393 A>V No 1000Genomes
tmp_1_6686747_G_C 398 W>C No 1000Genomes

No associated diseases with Q8LFA9

1 regional properties for Q8LFA9

Type Name Position InterPro Accession
conserved_site DNA methylase, N-6 adenine-specific, conserved site 230 - 236 IPR002052

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
nucleic acid binding Binding to a nucleic acid.

2 GO annotations of biological process

Name Definition
macromolecule methylation The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
nucleic acid metabolic process Any cellular metabolic process involving nucleic acids.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKTDKLAQF LDSGIYESDE FNWFFLDTVR ITNRSYTRFK VSPSAYYSRF FNSKQLNQHS
70 80 90 100 110 120
SESNPKKRKR KQKNSSFHLP SVGEQASNLR HQEARLFLSK AHESFLKEIE LLSLTKGLSD
130 140 150 160 170 180
DNDDDDSSLL NKCCDDEVSF IELGGVWQAP FYEITLSFNL HCDNEGESCN EQRVFQVFNN
190 200 210 220 230 240
LVVNEIGEEV EAEFSNRRYI MPRNSCFYMS DLHHIRNLVP AKSEEGYNLI VIDPPWENAS
250 260 270 280 290 300
AHQKSKYPTL PNQYFLSLPI KQLAHAEGAL VALWVTNREK LLSFVEKELF PAWGIKYVAT
310 320 330 340 350 360
MYWLKVKPDG TLICDLDLVH HKPYEYLLLG YHFTELAGSE KRSDFKLLDK NQIIMSIPGD
370 380 390 400 410
FSRKPPIGDI LLKHTPGSQP ARCLELFARE MAAGWTSWGN EPLHFQDSRY FLKV