Q8LF97
Gene name |
ASK21 (At3g61415, F2A19.5) |
Protein name |
SKP1-like protein 21 |
Names |
AtSK21 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G61415 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LF97
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LF97-F1 | Predicted | AlphaFoldDB |
13 variants for Q8LF97
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_22725131_C_A | 13 | M>I | No | 1000Genomes | |
| tmp_3_22725120_T_A | 17 | Y>F | No | 1000Genomes | |
| ENSVATH06355030 | 196 | V>I | No | 1000Genomes | |
| tmp_3_22723770_C_T | 230 | E>K | No | 1000Genomes | |
| tmp_3_22723742_G_C | 239 | T>R | No | 1000Genomes | |
| tmp_3_22723643_G_A | 248 | H>Y | No | 1000Genomes | |
| tmp_3_22723621_T_A | 255 | Q>L | No | 1000Genomes | |
| ENSVATH12868968 | 263 | T>S | No | 1000Genomes | |
| ENSVATH00430868 | 266 | C>S | No | 1000Genomes | |
| tmp_3_22723559_T_A | 276 | M>L | No | 1000Genomes | |
| tmp_3_22723224_C_T | 324 | G>E | No | 1000Genomes | |
| tmp_3_22723206_A_T | 330 | V>E | No | 1000Genomes | |
| tmp_3_22723195_T_C | 334 | I>V | No | 1000Genomes |
No associated diseases with Q8LF97
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cullin family protein binding | Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| jasmonic acid mediated signaling pathway | The series of molecular signals mediated by jasmonic acid. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| response to jasmonic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O81058 | ASK19 | SKP1-like protein 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEGEMAIIK | PEMMKSYIWL | ETADGSIQQV | EQEVAMFCPM | ICQEVIQKGV | GSSKNYAISL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQRVNPAMLS | LIFDYCRFHQ | VPGRSNKERK | VYDEKFIRMD | TKRLCELTSA | ADSLQLKPLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLTSRALARI | IEGKTPEEIR | EIFHLPDDLT | EEEKLEPLKN | TMDDPRIRLL | NRLYAKKRKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKEREKLKSV | EVEEHVDERS | VDDLLSFING | RDPKVVKTSK | SKKKNKKRKE | QKNGSSNGTC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EALEKDLHNL | DSKSQSAEIV | DNTASCLGDV | SNLPSMEDDI | FTPKTEFEDG | YIDDEIDPAL |
| 310 | 320 | 330 | 340 | 350 | |
| KELLDREVED | FARRLNSSWV | LSIGQERQPV | NFSINGNGTS | RRLTGPAAGH | K |