Q8LC76

PR
Gene name
CYS7 (At5g05110, MUG13.3)
Protein name
Cysteine proteinase inhibitor 7
Names
AtCYS-7
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G05110
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8LC76

Entry ID Method Resolution Chain Position Source
AF-Q8LC76-F1 Predicted AlphaFoldDB

33 variants for Q8LC76

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06924884 2 D>A No 1000Genomes
tmp_5_1508738_T_A 10 M>L No 1000Genomes
tmp_5_1508735_T_C 11 M>V No 1000Genomes
tmp_5_1508731_A_G 12 L>S No 1000Genomes
ENSVATH06924883 17 L>F No 1000Genomes
ENSVATH06924882 19 L>F No 1000Genomes
ENSVATH06924881 22 G>D No 1000Genomes
tmp_5_1508668_T_A 33 K>I No 1000Genomes
ENSVATH10581361 34 G>R No 1000Genomes
ENSVATH00607243 36 Y>S No 1000Genomes
ENSVATH06924880 38 D>H No 1000Genomes
ENSVATH03024944 49 S>R No 1000Genomes
ENSVATH00607242 55 W>R No 1000Genomes
ENSVATH06924879 59 K>E No 1000Genomes
tmp_5_1508307_A_T 77 N>K No 1000Genomes
tmp_5_1508249_G_T 97 L>I No 1000Genomes
ENSVATH10581356 115 A>G No 1000Genomes
ENSVATH06924866 134 I>V No 1000Genomes
ENSVATH10581355 139 T>S No 1000Genomes
ENSVATH06924865 140 I>V No 1000Genomes
tmp_5_1508113_T_C 142 D>G No 1000Genomes
ENSVATH10581312 166 E>K No 1000Genomes
tmp_5_1507916_G_A 167 A>V No 1000Genomes
ENSVATH10581311 168 A>T No 1000Genomes
ENSVATH06924862 178 K>I No 1000Genomes
ENSVATH03024933 195 A>E No 1000Genomes
ENSVATH03024927 200 E>D No 1000Genomes
ENSVATH06924856 201 R>S No 1000Genomes
ENSVATH03024926 204 F>V No 1000Genomes
tmp_5_1507692_G_C 208 L>V No 1000Genomes
ENSVATH06924855 212 R>M No 1000Genomes
ENSVATH06924854 223 V>G No 1000Genomes
tmp_5_1507639_C_A 225 K>N No 1000Genomes

No associated diseases with Q8LC76

3 regional properties for Q8LC76

Type Name Position InterPro Accession
domain Cystatin domain 43 - 134 IPR000010-1
domain Cystatin domain 154 - 215 IPR000010-2
conserved_site Proteinase inhibitor I25, cystatin, conserved site 90 - 103 IPR018073

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
cysteine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

1 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDMRRASMCM MLICVSLVLL SGFGQFVICS EEKGTYNDNV VKMKLGGFSD SKNDWNGGKE
70 80 90 100 110 120
IDDIALFAVQ EHNRRENAVL ELARVLKATE QVVAGKLYRL TLEVIEAGEK KIYEAKVWVK
130 140 150 160 170 180
PWMNFKQLQE FKNIIPSFTI SDLGFKPDGN GFDWRSVSTN NPEVQEAAKH AMKSLQQKSN
190 200 210 220 230
SLFPYKLIDI ILARAKVVEE RVKFELLLKL ERGNKLEKFM VEVMKDQTGK YE