Q8L785
PR
Gene name |
EDD1 |
Protein name |
Glycine--tRNA ligase, chloroplastic/mitochondrial 2 |
Names |
Glycyl-tRNA synthetase 2, GlyRS-2, Protein EMBRYO-DEFECTIVE-DEVELOPMENT 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G48110 |
EC number |
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8L785
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8L785-F1 | Predicted | AlphaFoldDB |
78 variants for Q8L785
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_17763162_C_T,A | 18 | H>N | No | 1000Genomes | |
| tmp_3_17763162_C_T,A | 18 | H>Y | No | 1000Genomes | |
| tmp_3_17763166_C_T | 19 | A>V | No | 1000Genomes | |
| tmp_3_17763216_C_T | 36 | L>F | No | 1000Genomes | |
| ENSVATH02466817 | 47 | V>I | No | 1000Genomes | |
| ENSVATH02466818 | 50 | A>P | No | 1000Genomes | |
| tmp_3_17763293_C_A | 61 | D>E | No | 1000Genomes | |
| ENSVATH06266339 | 68 | V>E | No | 1000Genomes | |
| tmp_3_17763319_T_C | 70 | V>A | No | 1000Genomes | |
| tmp_3_17763505_G_C | 102 | G>R | No | 1000Genomes | |
| ENSVATH00407133 | 154 | D>E | No | 1000Genomes | |
| tmp_3_17764375_C_T | 222 | P>S | No | 1000Genomes | |
| tmp_3_17764529_G_A | 242 | D>N | No | 1000Genomes | |
| tmp_3_17764771_C_A | 292 | S>Y | No | 1000Genomes | |
| ENSVATH06266362 | 315 | I>V | No | 1000Genomes | |
| tmp_3_17765184_C_T | 347 | A>V | No | 1000Genomes | |
| ENSVATH12628844 | 361 | E>K | No | 1000Genomes | |
| ENSVATH02466832 | 368 | H>Q | No | 1000Genomes | |
| ENSVATH06266365 | 371 | A>V | No | 1000Genomes | |
| tmp_3_17765856_C_T | 421 | R>W | No | 1000Genomes | |
| ENSVATH12628873 | 440 | A>V | No | 1000Genomes | |
| ENSVATH06266395 | 442 | S>F | No | 1000Genomes | |
| tmp_3_17766260_G_C | 450 | V>L | No | 1000Genomes | |
| tmp_3_17766294_T_A | 461 | F>Y | No | 1000Genomes | |
| ENSVATH14398383 | 481 | P>S | No | 1000Genomes | |
| ENSVATH06266398 | 489 | V>L | No | 1000Genomes | |
| tmp_3_17767127_T_G | 518 | I>R | No | 1000Genomes | |
| tmp_3_17767146_C_A | 524 | F>L | No | 1000Genomes | |
| ENSVATH12628925 | 525 | P>R | No | 1000Genomes | |
| ENSVATH00407143 | 535 | M>I | No | 1000Genomes | |
| tmp_3_17767286_G_A | 537 | S>N | No | 1000Genomes | |
| tmp_3_17767307_T_C | 544 | M>T | No | 1000Genomes | |
| tmp_3_17767306_A_G | 544 | M>V | No | 1000Genomes | |
| ENSVATH00407144 | 547 | H>Y | No | 1000Genomes | |
| ENSVATH14398396 | 552 | V>L | No | 1000Genomes | |
| ENSVATH06266411 | 553 | P>Q | No | 1000Genomes | |
| ENSVATH06266412 | 555 | S>F | No | 1000Genomes | |
| tmp_3_17767479_G_A | 564 | V>I | No | 1000Genomes | |
| ENSVATH00407146 | 574 | A>S | No | 1000Genomes | |
| ENSVATH00407147 | 579 | Q>L | No | 1000Genomes | |
| ENSVATH06266420 | 582 | E>G | No | 1000Genomes | |
| tmp_3_17767639_A_G | 588 | M>V | No | 1000Genomes | |
| ENSVATH14398399 | 610 | A>T | No | 1000Genomes | |
| ENSVATH00407149 | 616 | S>N | No | 1000Genomes | |
| ENSVATH06266427 | 627 | N>K | No | 1000Genomes | |
| tmp_3_17768016_G_A | 633 | V>I | No | 1000Genomes | |
| tmp_3_17768083_T_C | 655 | L>S | No | 1000Genomes | |
| ENSVATH06266439 | 694 | K>T | No | 1000Genomes | |
| tmp_3_17768456_T_A | 696 | N>K | No | 1000Genomes | |
| tmp_3_17768682_C_G | 715 | T>R | No | 1000Genomes | |
| tmp_3_17768691_G_A | 718 | R>K | No | 1000Genomes | |
| ENSVATH14398403 | 739 | L>Q | No | 1000Genomes | |
| ENSVATH06266453 | 749 | V>L | No | 1000Genomes | |
| tmp_3_17769026_G_A | 759 | D>N | No | 1000Genomes | |
| ENSVATH12628938 | 789 | S>L | No | 1000Genomes | |
| ENSVATH06266454 | 794 | R>C | No | 1000Genomes | |
| tmp_3_17769147_G_A | 799 | R>K | No | 1000Genomes | |
| tmp_3_17769157_T_A | 802 | Y>* | No | 1000Genomes | |
| tmp_3_17769156_A_T | 802 | Y>F | No | 1000Genomes | |
| tmp_3_17769360_T_A | 818 | F>I | No | 1000Genomes | |
| ENSVATH00407153 | 834 | I>V | No | 1000Genomes | |
| tmp_3_17769635_C_T | 847 | A>V | No | 1000Genomes | |
| ENSVATH06266461 | 854 | T>A | No | 1000Genomes | |
| tmp_3_17769855_G_A | 887 | A>T | No | 1000Genomes | |
| ENSVATH00407155 | 893 | T>R | No | 1000Genomes | |
| ENSVATH06266465 | 902 | D>N | No | 1000Genomes | |
| tmp_3_17770135_C_G | 918 | N>K | No | 1000Genomes | |
| tmp_3_17770203_G_A | 941 | R>Q | No | 1000Genomes | |
| ENSVATH14398416 | 956 | P>L | No | 1000Genomes | |
| ENSVATH14398417 | 968 | I>L | No | 1000Genomes | |
| ENSVATH14398418 | 980 | V>M | No | 1000Genomes | |
| ENSVATH00407159 | 987 | T>I | No | 1000Genomes | |
| ENSVATH00407162 | 1012 | D>E | No | 1000Genomes | |
| tmp_3_17770748_G_A | 1022 | E>K | No | 1000Genomes | |
| tmp_3_17770897_C_G | 1046 | A>G | No | 1000Genomes | |
| ENSVATH00407164 | 1049 | N>S | No | 1000Genomes | |
| ENSVATH06266477 | 1052 | A>T | No | 1000Genomes | |
| tmp_3_17770953_C_T | 1065 | P>S | No | 1000Genomes |
No associated diseases with Q8L785
No regional properties for Q8L785
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8L785 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.14 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glycine-tRNA ligase activity | Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). |
| protein dimerization activity | The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| glycyl-tRNA aminoacylation | The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. |
| regulation of embryonic development | Any process that modulates the frequency, rate or extent of embryonic development. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAILHFSLPL | IVSFLRPHAS | PRFFLLPRSL | SQSPFLSRRR | FHRTSAVSSA | AVHHQSYRNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDDVTRAVSV | PTFQQAIQRL | QEYWASVGCA | VMQPSNTEVG | AGTMNPCTFL | RVLGPEPWNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AYVEPSIRPD | DSRYGENPNR | LQRHTQFQVI | LKPDPGNSQQ | LFINSLSALG | IDVTAHDIRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VEDNWESPVL | GAWGLGWEIW | MDGMEITQFT | YFQQAGSLPL | SPVSVEITYG | LERIIMLLQE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDHFKKILYA | DGITYGELFL | ENEKEMSSYY | LEHASVDRLQ | KHFDYFDEEA | RSLLALGLPI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PAYDQLLKTS | HAFNILDARG | FIGVTERARY | FGRMRSLARQ | CAQLWLATRE | SLGHPLGVAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EPVPPVCHRA | ALEKVAEKVS | EDPRSFIIEI | GTEEMPPQDV | INASEQLRVL | VLELLENQRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RHGAVKAFGT | PRRLVVLVDA | MSSKQLEEEV | EVRGPPASKA | FDDEGNPTKA | AEGFSRRYGV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLEKLYRKVS | GKTEYVHARV | TEPARLALEV | LSEDLPGILA | KISFPKSMRW | NSSVMFSRPI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RWVMALHGDL | VVPFSFAGIS | SGNVSCGLRN | TASASLLVQN | AESYEDTMRN | SGINIEIEER |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KKIILEKSNA | LAKSVSGRLV | VPQNLLNEVA | NLVEAPVPLI | GKFKESFLEL | PEELLTIVMQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KHQKYFSIID | ESGQLLPYFI | AVANGAINED | VVKKGNEAVL | RARYEDAKFF | YEVDTRKRFS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EFRDQLQGIL | FHEKLGTMLD | KMNRLKKMVS | KLCLALKIDE | DLLPVVEDAA | SLAMSDLATA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VVTEFTALSG | IMARHYALRD | GYSEQIAEAL | LEITLPRFSG | DVIPKTDAGM | VLAIGDRLDS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LVGLFAAGCQ | PSSTNDPFGL | RRISYGLVQI | LVEKDKNVNF | KRVLELAASV | QPTKVEANTV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EDVYQFVTRR | LEQLLVDNGV | SPEVVRSVLA | ERGNNPCLAA | RTAYKTEKLS | KGEMFPKIVE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AYSRPTRIVR | GKDVGVGVEV | DENAFETPQE | RTLWSTYTSI | KDRIHTGIEI | EDFTEISMQL |
| 1030 | 1040 | 1050 | 1060 | ||
| VEPLEDFFNN | VFVMVEEERV | RKNRLALLNN | IANLPKGVID | LSFLPGF |