Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8L611

Entry ID Method Resolution Chain Position Source
AF-Q8L611-F1 Predicted AlphaFoldDB

53 variants for Q8L611

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14473903 4 I>L No 1000Genomes
ENSVATH14473902 7 V>G No 1000Genomes
ENSVATH14473901 14 A>S No 1000Genomes
ENSVATH06365403 73 G>E No 1000Genomes
tmp_3_23436926_C_T 106 G>S No 1000Genomes
tmp_3_23436728_T_C 122 K>R No 1000Genomes
ENSVATH06365397 171 T>S No 1000Genomes
ENSVATH06365396 191 T>A No 1000Genomes
tmp_3_23435303_T_C 333 I>V No 1000Genomes
tmp_3_23435296_T_C 335 N>S No 1000Genomes
tmp_3_23434976_C_T 341 R>H No 1000Genomes
ENSVATH06365379 348 N>T No 1000Genomes
ENSVATH06365378 350 G>S No 1000Genomes
tmp_3_23434792_G_A 363 P>L No 1000Genomes
tmp_3_23434711_A_T 390 L>Q No 1000Genomes
ENSVATH12898842 437 E>K No 1000Genomes
ENSVATH06365370 474 D>N No 1000Genomes
ENSVATH12898841 491 D>V No 1000Genomes
ENSVATH02539732 493 A>V No 1000Genomes
ENSVATH06365369 494 A>P No 1000Genomes
tmp_3_23434216_A_C 495 D>E No 1000Genomes
tmp_3_23434113_T_C 530 T>A No 1000Genomes
tmp_3_23434091_G_A 537 P>L No 1000Genomes
tmp_3_23434073_G_T 543 S>Y No 1000Genomes
ENSVATH14473898 552 M>T No 1000Genomes
ENSVATH12898840 600 G>D No 1000Genomes
tmp_3_23433721_G_A 626 A>V No 1000Genomes
ENSVATH00803250 629 N>S No 1000Genomes
tmp_3_23432983_G_A 749 A>V No 1000Genomes
tmp_3_23432911_A_T 773 L>H No 1000Genomes
tmp_3_23432879_C_G 784 A>P No 1000Genomes
tmp_3_23432786_T_A 789 N>I No 1000Genomes
ENSVATH06365356 796 T>I No 1000Genomes
tmp_3_23432757_G_C 799 Q>E No 1000Genomes
tmp_3_23432504_T_A,G 852 Q>L No 1000Genomes
tmp_3_23432504_T_A,G 852 Q>P No 1000Genomes
ENSVATH00803246 866 T>A No 1000Genomes
ENSVATH06365347 869 A>P No 1000Genomes
tmp_3_23431963_C_T 873 M>I No 1000Genomes
tmp_3_23431956_T_C 876 T>A No 1000Genomes
tmp_3_23431931_G_A 884 A>V No 1000Genomes
ENSVATH14473864 889 D>N No 1000Genomes
ENSVATH12898798 895 T>I No 1000Genomes
tmp_3_23431790_G_T 904 P>Q No 1000Genomes
ENSVATH12898796 920 P>H No 1000Genomes
ENSVATH06365343 929 Y>S No 1000Genomes
ENSVATH06365342 934 M>I No 1000Genomes
tmp_3_23431677_C_T 942 A>T No 1000Genomes
tmp_3_23431676_G_A 942 A>V No 1000Genomes
tmp_3_23431659_T_C 948 T>A No 1000Genomes
tmp_3_23431608_G_T 965 P>T No 1000Genomes
tmp_3_23431578_C_A 975 A>S No 1000Genomes
tmp_3_23431529_G_A 991 S>F No 1000Genomes

No associated diseases with Q8L611

No regional properties for Q8L611

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8L611

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum exit site An endoplasmic reticulum part at which COPII-coated vesicles are produced.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

3 GO annotations of biological process

Name Definition
COPII-coated vesicle cargo loading The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.
endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MACIKGVGRS ASVALAPDAP YMAAGTMAGA VDLSFSSSAN LEIFKLDFQS DDRDLPLVGE
70 80 90 100 110 120
IPSSERFNRL AWGRNGSGSE EFALGLIAGG LVDGNIDLWN PLSLIGSQPS ENALVGHLSV
130 140 150 160 170 180
HKGPVRGLEF NAISSNLLAS GADDGEICIW DLLKPSEPSH FPLLKGSGSA TQGEISFISW
190 200 210 220 230 240
NRKVQQILAS TSYNGTTVIW DLRKQKPIIN FADSVRRRCS VLQWNPNVTT QIMVASDDDS
250 260 270 280 290 300
SPTLKLWDMR NIMSPVREFT GHQRGVIAME WCPSDSSYLL TCAKDNRTIC WDTNTAEIVA
310 320 330 340 350 360
ELPAGNNWNF DVHWYPKIPG VISASSFDGK IGIYNIEGCS RYGVEENNFG TAPLKAPKWY
370 380 390 400 410 420
KRPVGASFGF GGKLVSCHAR APAKGTSSIL SEVFLHSLVT EQSLVSRTSE FEAAIENGDM
430 440 450 460 470 480
TSLRGLCEKK SEETESEEEK ETWGLLKIMF EEEGTSRTKL ISHLGFTLPV AEKDQAVDGL
490 500 510 520 530 540
SSDLNGIRLE DTAADALDLD DSNEAAAFAM DNGEDFFNNF PAKPDTPVST SAKDFMPSDT
550 560 570 580 590 600
DFSTKGEETQ EMQEEEEESS DPVFDNAIQR ALIVGDYKEA VDQCITANKM ADALVIAHVG
610 620 630 640 650 660
GTALWESTRE KYLKTSSAPY MKVVSAMVNN DLRSLIYTRS HKFWKETLAL LCTFAQGEQW
670 680 690 700 710 720
TTLCDALASK LMAAGNTLAA VLCYICAGNV DRTVEIWSRS LANERDGRSY AELLQDLMEK
730 740 750 760 770 780
TLVLALATGN KKFSASLCKL FESYAEILAS QGLLTTAMKY LKVLDSGGLS PELSILRDRI
790 800 810 820 830 840
SLSAEPETNT TASGNTQPQS TMPYNQEPTQ AQPNVLANPY DNQYQQPYTD SYYVPQVSHP
850 860 870 880 890 900
PMQQPTMFMP HQAQPAPQPS FTPAPTSNAQ PSMRTTFVPS TPPALKNADQ YQQPTMSSHS
910 920 930 940 950 960
FTGPSNNAYP VPPGPGQYAP SGPSQLGQYP NPKMPQVVAP AAGPIGFTPM ATPGVAPRSV
970 980 990 1000 1010 1020
QPASPPTQQA AAQAAPAPAT PPPTVQTADT SNVPAHQKPV IATLTRLFNE TSEALGGARA
1030 1040 1050 1060 1070 1080
NTTKKREIED NSRKLGALFV KLNSGDISKN AADKLAQLCQ ALDNNDFSTA LQIQVLLTTS
1090 1100
EWDECNFWLA TLKRMMVKAR QNVR