Q8KIY1

PR
Gene name
tmoS
Protein name
Sensor histidine kinase TmoS
Names
Species
Pseudomonas mendocina
KEGG Pathway
EC number
2.7.13.3: Protein-histidine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8KIY1

Entry ID Method Resolution Chain Position Source
AF-Q8KIY1-F1 Predicted AlphaFoldDB

No variants for Q8KIY1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8KIY1

No associated diseases with Q8KIY1

19 regional properties for Q8KIY1

Type Name Position InterPro Accession
domain PAS domain 32 - 160 IPR000014-1
domain PAS domain 610 - 735 IPR000014-2
domain PAS-associated, C-terminal 108 - 162 IPR000700-1
domain PAS-associated, C-terminal 685 - 737 IPR000700-2
repeat PAC motif 109 - 153 IPR001610-1
repeat PAC motif 686 - 728 IPR001610-2
domain Signal transduction response regulator, receiver domain 451 - 567 IPR001789
domain Histidine kinase/HSP90-like ATPase 292 - 405 IPR003594-1
domain Histidine kinase/HSP90-like ATPase 862 - 973 IPR003594-2
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 178 - 247 IPR003661-1
domain Signal transduction histidine kinase, dimerisation/phosphoacceptor domain 748 - 820 IPR003661-2
domain Signal transduction histidine kinase-related protein, C-terminal 330 - 344 IPR004358-1
domain Signal transduction histidine kinase-related protein, C-terminal 348 - 358 IPR004358-2
domain Signal transduction histidine kinase-related protein, C-terminal 365 - 383 IPR004358-3
domain Signal transduction histidine kinase-related protein, C-terminal 389 - 402 IPR004358-4
domain Histidine kinase domain 187 - 405 IPR005467-1
domain Histidine kinase domain 757 - 973 IPR005467-2
domain PAS fold-4 42 - 154 IPR013656
domain PAS fold 614 - 722 IPR013767

Functions

Description
EC Number 2.7.13.3 Protein-histidine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.

1 GO annotations of biological process

Name Definition
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSLDKRKTQ NRSKKNSYSI CLKEKASAEL KREELARIIF DGLYEFVGLL DAQGNVLEVN
70 80 90 100 110 120
QAALNGAGVT LEEIRGKPFW KARWWQISKE SVANQKRLVE AASSGEFVRC DIEILGKSGG
130 140 150 160 170 180
REVIAVDFSL LPIRDEQENI VFLLAEGRNI TDKKKAEAML ALKNHELEQL VERIRKLDNA
190 200 210 220 230 240
KSDFFAKVSH ELRTPLSLIL GPLETIMEAE SGRGSPYWKK FEVIQRNAMT LLKQVNTLLD
250 260 270 280 290 300
LAKMDAQQMG LSYRRADLSQ LTRVISSNFD GIAQQKSITL DAELPPHLIA EVDCEKYERI
310 320 330 340 350 360
ILNLLSNAFK FTPDGGLIRC HLSLSQPAHA LITVSDSGPG IPQNLRKEIF ERFHQLNQEG
370 380 390 400 410 420
QQANQGTGLG LSIVKEFVEL HHGTISVSDA PGGGALFQVK LPLNAPEGAY VANNAMSRSD
430 440 450 460 470 480
NPQTVNPDEY LLPIPTAGSG AELPQFQSDQ PRVLIVEDNP DMRCFIRDCL STDYQVYVAP
490 500 510 520 530 540
DGAKALELMC SAPPDLLITD LMMPVMSGDT LVHKVREKNE FAHIPIMVLS AKPDEKLRVK
550 560 570 580 590 600
LLSESVQDYL LKPFSAHELR ARVSNLISMK IAGDALRKEL SDQSNDIALL THRLIKSRHR
610 620 630 640 650 660
LQQSNIALTA SEARWKAVYE NSAAGIVLTD TENRILNANP AFQRITGYTE KDLAQLSMEQ
670 680 690 700 710 720
LTPPNERTQM KQRLARLLQS GGAEYSVECS YLCKNGSTIW ANASVSLMSP RVDEPQVILQ
730 740 750 760 770 780
IIDDITEKKQ AQETLNQLQQ ELVQVSRSAT MGEFAAYIAH EINQPLSAIM TNANAGTRWI
790 800 810 820 830 840
GNEPPNIMEA KEALARIIRD SDRAADIIRM VRSFLKRQGP VLKPIDLKAL VADTTLILKA
850 860 870 880 890 900
PSQSNGVSLN VIAGDTLPAI MGDAVQIQQL VINLAMNSIE AMSQVGCETR QLALSFSSNA
910 920 930 940 950 960
SNDALIICVK DTGPGIPEDQ IGQLFNAFYT TKKEGLGMGL AICLTIAEVH NGKIWAESPP
970
AGGACFFVSI PVS