Q8KGB6

PR
Gene name
bioB
Protein name
Biotin synthase
Names
Species
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
KEGG Pathway
cte:CT0052
EC number
2.8.1.6: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

287-333 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8KGB6

Entry ID Method Resolution Chain Position Source
AF-Q8KGB6-F1 Predicted AlphaFoldDB

No variants for Q8KGB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8KGB6

No associated diseases with Q8KGB6

3 regional properties for Q8KGB6

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 62 - 271 IPR006638
domain Radical SAM 15 - 329 IPR007197
domain Biotin and thiamin synthesis-associated domain 242 - 333 IPR010722

Functions

Description
EC Number 2.8.1.6 Sulfurtransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
biotin synthase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
iron ion binding Binding to an iron (Fe) ion.

1 GO annotations of biological process

Name Definition
biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSRLHPDIE KAYAVLDTGE PLSLELASAL GRLPDSEVLD LVSLANRVKA RHAANHGAIH
70 80 90 100 110 120
ACSIMNAKSG VCGENCRFCA QSKHNSAEVD VYELVDENKV LEQARSAWEQ GIGHFGIVTS
130 140 150 160 170 180
GYGYLKVTPE FERILGMIDR LHRELPGLHV CASLGVLGDA PAAELARHGI AHYNINIQVD
190 200 210 220 230 240
PARYGELIAD THAVNERIGT IRRLRSNGIG VCCGGILGVG ETMQERIGMI FALRDLDVTV
250 260 270 280 290 300
IPLNVLVPID GTPLEGAAPV SVPEIAKTFA ICRLAHPTKI IKFAAGRETV MKDFQGLLML
310 320 330
AGADGFLTGG YLTTRGRDIS TDRQLARQLS KFS