Q8KDU6

PR
Gene name
cobS
Protein name
Adenosylcobinamide-GDP ribazoletransferase
Names
Cobalamin synthase, Cobalamin-5'-phosphate synthase
Species
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
KEGG Pathway
cte:CT0948
EC number
2.7.8.26: Transferases for other substituted phosphate groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

123-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8KDU6

Entry ID Method Resolution Chain Position Source
AF-Q8KDU6-F1 Predicted AlphaFoldDB

No variants for Q8KDU6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8KDU6

No associated diseases with Q8KDU6

No regional properties for Q8KDU6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8KDU6

Functions

Description
EC Number 2.7.8.26 Transferases for other substituted phosphate groups
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
adenosylcobinamide-GDP ribazoletransferase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin.
cobalamin 5'-phosphate synthase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP.

1 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSGLVTALR TLTALPVPGR DAERFSSSLY WFPVVGLVIG GIVVLLARAG MGVGWPELAA
70 80 90 100 110 120
VLALLGGLIL TRGLHADGLA DLADGFFGGR TREAALRIMK DPNVGSFGSL ALIGVMLFKW
130 140 150 160 170 180
ICLLELARAE AYGMIAAGAV LSRTAQVLLA ARMPYARSDG GTAMAFVEDA GWPHLLVASI
190 200 210 220 230 240
SGVVLLFVLL DWQLAPSLIL LFGSVVALFF VGWLSHRKIG GITGDVLGAC SELVEAAVWL
250
LAALWLKGLF WAIA