Q8KB35

PR
Gene name
eno1
Protein name
Enolase 1
Names
2-phospho-D-glycerate hydro-lyase 1, 2-phosphoglycerate dehydratase 1
Species
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
KEGG Pathway
cte:CT1962
EC number
4.2.1.11: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8KB35

Entry ID Method Resolution Chain Position Source
AF-Q8KB35-F1 Predicted AlphaFoldDB

No variants for Q8KB35

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8KB35

No associated diseases with Q8KB35

3 regional properties for Q8KB35

Type Name Position InterPro Accession
conserved_site Enolase, conserved site 334 - 347 IPR020809
domain Enolase, C-terminal TIM barrel domain 138 - 425 IPR020810
domain Enolase, N-terminal 3 - 133 IPR020811

Functions

Description
EC Number 4.2.1.11 Hydro-lyases
Subcellular Localization
  • Cytoplasm
  • Secreted
  • Cell surface
  • Fractions of enolase are present in both the cytoplasm and on the cell surface
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.

2 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphopyruvate hydratase activity Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

1 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIQNVNAIE ILDSRGNPTV EVNLKLEDGT ISRAMVPSGA STGEREATEL RDGDKKRYGG
70 80 90 100 110 120
KGVLKAVENV NSAIAKAIEN KHFTNQRELD YFLIELDETN NKSKLGANAI LGVSMAFARA
130 140 150 160 170 180
KAQSSRTPLY QYLGGSNAHI MPVPCMNVIN GGKHADNTID FQEFMIAPHN APSFRESIRM
190 200 210 220 230 240
GEEVFHALKA VLKLKGLSTG VGDEGGFAPD LKSNEQAVEM ILEGITKAGY KPSVDVSICL
250 260 270 280 290 300
DPASSEMWEN GKYKFFKSTQ KLVSSDEMVK LWESWVNQYP IVLLEDGMAE NDWEGWKNLT
310 320 330 340 350 360
DVIGNKIEIV GDDLFCTNKS ILLNGINKGV ANSILIKLNQ IGTVTETLET IELAYKNSYN
370 380 390 400 410 420
CFVSHRSGET VDSFIADLTV GINAGHLKSG SGCRGERIEK FNQLMRIENE LGKSAQFAGL
KAFKNAK