Q8K9U9

PR
Gene name
thrA (BUsg_188)
Protein name
Bifunctional aspartokinase/homoserine dehydrogenase
Names
AK-HD
Species
Buchnera aphidicola subsp Schizaphis graminum (strain Sg)
KEGG Pathway
bas:BUsg_188
EC number
1.1.1.3: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

380-449 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K9U9

Entry ID Method Resolution Chain Position Source
AF-Q8K9U9-F1 Predicted AlphaFoldDB

No variants for Q8K9U9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8K9U9

No associated diseases with Q8K9U9

8 regional properties for Q8K9U9

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 3 - 283 IPR001048
domain Aspartate kinase 4 - 459 IPR001341
domain Homoserine dehydrogenase, catalytic 613 - 810 IPR001342
domain ACT domain 319 - 400 IPR002912
domain Aspartate/homoserine dehydrogenase, NAD-binding 471 - 605 IPR005106
conserved_site Aspartate kinase, conserved site 3 - 11 IPR018042
conserved_site Homoserine dehydrogenase, conserved site 659 - 681 IPR019811
domain Bifunctional aspartokinase/homoserine dehydrogenase, N-terminal catalytic domain 1 - 295 IPR041743

Functions

Description
EC Number 1.1.1.3 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
aspartate kinase activity Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
homoserine dehydrogenase activity Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

3 GO annotations of biological process

Name Definition
lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLLKFGGTS LANAKKFLCV ADIIEKKNKK EQIAVVLSAP AKITNYLATI IENKIDDEVL
70 80 90 100 110 120
KKINLAKNIF IELIQDIKRI QPLFPYENTK STIEIEFNKL KKIINGILLI KQCPEGIKPI
130 140 150 160 170 180
IISRGEILSV DIMKNILQSR NHEVTILNPV TNLLSIGNYL DSTIDIKESK KRIKKINIDQ
190 200 210 220 230 240
KNIILMAGFI AGNKEGELVV LGRNGSDYSA AILASCLNAK CCEIWTDVDG VLTADPRIVS
250 260 270 280 290 300
NTYLLDYISY QEAMELSYFG AKVLHPRTIE PISQFQIPCV IKNTNNTESK GTWIGKENNP
310 320 330 340 350 360
SDNSLKGVTY LDNIIMFNIS GSCLKDSGNT IARIFTILSR ESMKIILIIQ SSSENQINFC
370 380 390 400 410 420
TFEKDIDYIL LILKKEFTLE IKEGLLNDFN IVKNLTILSV IGSNISEKNN IASKIFSSLG
430 440 450 460 470 480
SSKINVLAIA HGSSKHSISI VIKKENLLQG IQNIHNTLFF KKTIINVFLI GIGGVGKALL
490 500 510 520 530 540
KQILKQEKFL DQKNIKIQFR MIANSKKLLF LKNSINLNNW EENFKKSKEK FNLTILNELL
550 560 570 580 590 600
KNTCDSNSVI IDCTSDYILS KQYISFIKKG FHIITSNKKA NTDSLKYYSE IRTTALKENK
610 620 630 640 650 660
KFLYETNVGA GLPVINTLQS LFSTGDCLIS FKGILSGSLS FIFGKLEEGV LLSEATKEAK
670 680 690 700 710 720
KLGFTEPNPF DDLSGIDVAR KLLVLAREIG YSIELKDISI EPILPERFKK YQNSEEFLFK
730 740 750 760 770 780
LKELDSFFSE RVNKARDIGN VLRFIGSIEK NGKCSVKIEE INSNNPLYKV KNGENALTFY
790 800 810
TNYYQPIPLV LRGYGAGNDV TASGVFSDLL RIIL