Q8K5B2
Gene name |
Mcfd2 (Sdnsf) |
Protein name |
Multiple coagulation factor deficiency protein 2 homolog |
Names |
Neural stem cell-derived neuronal survival protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:193813 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K5B2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K5B2-F1 | Predicted | AlphaFoldDB |
3 variants for Q8K5B2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13474682 | 95 | A>S | No | EVA | |
| rs3389474785 | 103 | E>G | No | EVA | |
| rs3389493370 | 112 | S>I | No | EVA |
No associated diseases with Q8K5B2
No regional properties for Q8K5B2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8K5B2 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum-Golgi intermediate compartment | A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
| negative regulation of cell death | Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATLQLLRAP | LLCVLLWVFC | APGARAHDHG | ADVHHGSVGL | DKSTVHDQEH | IMEHLEGVID |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPEAEMSPQE | LQLHYFKMHD | YDGNSLLDGL | ELSIAITHVH | KEEGSEQAPV | MSEDELVSII |
| 130 | 140 | ||||
| DGVLRDDDKN | NDGYIDYAEF | AKSLQ |