Q8K561

PR
Gene name
Otoa
Protein name
Otoancorin
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:246190
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

455-527 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K561

Entry ID Method Resolution Chain Position Source
AF-Q8K561-F1 Predicted AlphaFoldDB

88 variants for Q8K561

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388916731 2 S>T No EVA
rs240040770 5 P>S No EVA
rs3398434043 17 S>R No EVA
rs3388949586 25 E>V No EVA
rs1133683030 44 I>T No EVA
rs3388928294 72 V>I No EVA
rs32665955 79 K>R No EVA
rs32669289 95 H>Y No EVA
rs3388942506 106 L>M No EVA
rs235382495 108 E>Q No EVA
rs3388943685 120 T>I No EVA
rs3388949594 164 L>* No EVA
rs3388943694 177 V>M No EVA
rs32668135 198 E>D No EVA
rs3398532676 216 F>L No EVA
rs3398349287 220 Y>* No EVA
rs3388939988 241 T>I No EVA
rs3388937630 321 N>Y No EVA
rs3388916787 322 I>T No EVA
rs3388946395 327 R>K No EVA
rs3388928248 332 V>A No EVA
rs32666957 383 L>F No EVA
rs3398482557 389 S>I No EVA
rs32666960 414 I>T No EVA
rs3398565634 447 V>A No EVA
rs221995724 455 A>T No EVA
rs3388942458 459 T>M No EVA
rs3388946404 470 L>H No EVA
rs3388943733 472 Q>R No EVA
rs3388949015 477 P>T No EVA
rs3388933076 489 Q>K No EVA
rs246232316 493 V>I No EVA
rs1133556956 495 G>S No EVA
rs3398565668 496 K>Q No EVA
rs32671019 508 A>S No EVA
rs32671019 508 A>T No EVA
rs32671022 516 K>R No EVA
rs3388946220 548 Y>* No EVA
rs221226416 550 F>L No EVA
rs31403410 571 V>M No EVA
rs32671631 582 H>R No EVA
rs3388900926 583 L>I No EVA
rs221066952 586 A>T No EVA
rs3388947317 592 D>H No EVA
rs3388947370 611 W>L No EVA
rs3388949637 622 L>P No EVA
rs3388916789 627 P>T No EVA
rs49639828 634 I>V No EVA
rs51809010 657 D>N No EVA
rs3388947351 658 S>A No EVA
rs261035555 674 G>D No EVA
rs3388900871 687 H>R No EVA
rs51900635 695 S>T No EVA
rs3388942485 702 S>F No EVA
rs231030237 707 A>T No EVA
rs3388939952 714 R>K No EVA
rs3388943695 717 T>I No EVA
rs1133544707 729 V>I No EVA
rs3398715281 741 W>* No EVA
rs3398565607 741 W>* No EVA
rs3398483448 742 T>K No EVA
rs3388900842 746 T>S No EVA
rs3388928325 747 K>* No EVA
rs3398533880 752 F>V No EVA
rs3398491975 753 L>S No EVA
rs247094203 755 F>V No EVA
rs3388948977 781 G>E No EVA
rs3388924498 822 D>V No EVA
rs3388942464 834 D>N No EVA
rs224873823 842 E>A No EVA
rs242869395 862 A>S No EVA
rs263392870 880 R>H No EVA
rs3388933045 881 W>* No EVA
rs3388946254 884 H>Q No EVA
rs3388946377 889 L>Q No EVA
rs232267539 905 D>N No EVA
rs3388939907 916 G>D No EVA
rs246076081 932 A>S No EVA
rs3398483421 937 S>* No EVA
rs3398500515 941 I>L No EVA
rs257295682 952 F>L No EVA
rs256767179 1028 M>T No EVA
rs32675990 1030 N>D No EVA
rs234426163 1035 T>P No EVA
rs32673212 1109 P>A No EVA
rs3388942492 1112 T>N No EVA
rs246764562 1123 A>V No EVA
rs3398251611 1138 S>L No EVA

No associated diseases with Q8K561

No regional properties for Q8K561

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8K561

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side
  • Secreted, extracellular space, extracellular matrix
  • At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell surface The external part of the cell wall and/or plasma membrane.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
transmission of nerve impulse The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7RTW8 OTOA Otoancorin Homo sapiens (Human) PR
10 20 30 40 50 60
MSQGPRTCSL LLVLLLSHGG AYQREPSPRQ DLHPLLQKMA EEIIEGSYLN ALLDLTLFER
70 80 90 100 110 120
SHVWTADLSH RVLAYLNSKN VAFTIPSLQA VMEAHLEQYL YQPQKLLEDL RATDNQQFHT
130 140 150 160 170 180
AMKCLLEDKW GHLDLEDVVI NLGDIRDEAL QSPGVNRSLF LITLERCFQV LNALECVEVL
190 200 210 220 230 240
GRVLRGSSGS FLQPDITERL PQDLHEDAFK NLSAVFKDLY DQTSAHTQRA LYSWMTGILR
250 260 270 280 290 300
TPFNVTDGSV SWVSAEKLWI LGRYMVHLSF EEIMNISPIE IGLFISYDNA TKQLDMVYDI
310 320 330 340 350 360
TPELAQAFLE RIRCSSFDVR NISTIHRLGL LVCFYDGLEL LDATLAQVLL HQMLKCSRLR
370 380 390 400 410 420
GFQAGVQKLK ANLLDIATEN QTLNETLGSL SDAVVGLTSS QLESLSSDAV HSAISTLNQV
430 440 450 460 470 480
TGWGRSQIVI LSAKYLAQEK VLSFYNVCQM GVLLAGVGTQ AFYSMDHKDL WQVLRSPLSQ
490 500 510 520 530 540
DMSDLSPVQQ QGVLGKLMEA EDATSGIAEV PRALFKEVSL YDLWKESRFN ATVLKAKELR
550 560 570 580 590 600
RSQALFLYEF LGKTTERPEE LLSAGQLVKG VPCSHIDAMS DHLFLALFQY FDNNFSLLSP
610 620 630 640 650 660
DQVNCLAWKY WEVSRSSMPP FLLATLPSRF LSSIPPSRCV RFLISLGKRR LETLVLDSDK
670 680 690 700 710 720
RSVVVRKVQQ CLDGVIADEY TVDIVGHLLC HLPASFIERG ISPRAWAAAL HGLRSCTALS
730 740 750 760 770 780
SEQKAAVRVR LLEQWGPPEN WTAETTKDLA PFLAFFSGDE LHTVATKFPE ILQQTASKMV
790 800 810 820 830 840
GVLLPKEFLW AVFESVQNSS NESPSFDPTF GCHGVVTPSS DDIFKLAEAN ACWDPEVLLC
850 860 870 880 890 900
MEEDTFIRNV ELLGAVKGFS RAQLMALKEK AIQVWDLPSR WKEHHIVSLG RIALALSESE
910 920 930 940 950 960
LEQLDLSSID TVASLGQQTE WTPGQAKSIL QAFLEDSGYG IQDLKSFHLV GFGPTLCAMD
970 980 990 1000 1010 1020
PTEIQLIKTS EFRAVVARIG TLFCSTPVLA GFKKKAEVVF GRPTEWTSSI LQELGTIAAG
1030 1040 1050 1060 1070 1080
ITKAELRMLN KELMTYFQPS AIRCLPGEVF KELSTEQIAS LGPQNAASVT HSQRLQLSSA
1090 1100 1110 1120 1130
QLQSLQRALD GAKTHSWQTD PLSSSPTWPA STGSPTGEPA SQALWLGCTL LLLTAKS