AiPD: Autoinhibited Protein Database

Gene name	Ebf4 (Coe4)
Protein name	Transcription factor COE4
Names	Early B-cell factor 4, EBF-4, Olf-1/EBF-like 4, O/E-4, OE-4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:228598
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

422-505 (Predicted disordered autoinhibitory region) PR

422-505 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K4J2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388584367	52	R>*	No	EVA
rs3388590709	111	Y>C	No	EVA
rs3388587978	135	M>I	No	EVA
rs3388584375	190	K>I	No	EVA
rs3388580158	211	R>H	No	EVA
rs3388585434	218	T>A	No	EVA
rs3388594025	222	V>M	No	EVA
rs3388592749	223	D>V	No	EVA
rs3388580192	269	T>M	No	EVA
rs3388585122	280	N>S	No	EVA
rs3388593122	281	F>V	No	EVA
rs3388595747	284	G>R	No	EVA
rs3388585067	375	R>K	No	EVA
rs3388589711	457	A>S	No	EVA
rs3388593991	458	S>Y	No	EVA
rs3388593157	466	G>R	No	EVA
rs3388589718	469	Q>R	No	EVA
rs3388585061	515	S>T	No	EVA
rs3388592578	516	P>S	No	EVA
rs3388595640	596	L>F	No	EVA

Type	Name	Position	InterPro Accession
domain	IPT domain	255 - 339	IPR002909
conserved_site	Transcription factor COE, conserved site	162 - 171	IPR018350
domain	Transcription factor COE, DNA-binding domain	22 - 248	IPR032200
domain	Transcription factor COE, helix-loop-helix domain	341 - 384	IPR032201
domain	Transcription factor COE, IPT domain	256 - 340	IPR038006

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.

Name	Definition
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins