Q8K4I3
Gene name |
Arhgef6 |
Protein name |
Rho guanine nucleotide exchange factor 6 |
Names |
Alpha-PIX, Rac/Cdc42 guanine nucleotide exchange factor 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73341 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q8K4I3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1V61 | NMR | - | A | 429-547 | PDB |
| AF-Q8K4I3-F1 | Predicted | AlphaFoldDB |
No variants for Q8K4I3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8K4I3 | |||||
No associated diseases with Q8K4I3
8 regional properties for Q8K4I3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 240 - 420 | IPR000219 |
| conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | 368 - 393 | IPR001331 |
| domain | SH3 domain | 159 - 218 | IPR001452 |
| domain | Calponin homology domain | 1 - 111 | IPR001715 |
| domain | Pleckstrin homology domain | 442 - 549 | IPR001849 |
| domain | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain | 680 - 763 | IPR032409 |
| domain | Rho guanine nucleotide exchange factor 6, SH3 domain | 161 - 217 | IPR035788 |
| domain | RhoGEF 6/7, PH domain | 449 - 547 | IPR046376 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lamellipodium assembly | Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15052 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNPEERLVTW | LISLGVLESP | KKTVCDPEEF | LKSSLKNGVV | LCKLINRLLP | GSVEKYCLEP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QTEADCIDNI | NDFLKGCATL | QVEVFEPDDL | YSGANFSKVL | NTLLAVNKAT | EDQLSERPCG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RSSSLSAATS | SQTNPQVAVP | STAPEQHSEE | KAEMTENGSH | QLIVKARFNF | KQTNEDELSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CKGDIIYVTR | VEEGGWWEGT | LNGRTGWFPS | NYVREIKPSE | RPLSPKAIKG | FDTAPLTKNY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YTVVLQNILD | TEKEYAKELQ | SLLVTYLRPL | QSNNNLSTVE | FTCLLGNFEE | VCTFQQTLCQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALEECSKFPE | NQHKVGGCLL | NLMPHFKSMY | LAYCANHPSA | VNVLTQHSDD | LERFMENQGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSPGILILTT | SLSKPFMRLE | KYVTLLQELE | RHMEDTHPDH | QDILKAIIAF | KTLMGQCQDL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RKRKQLELQI | LSEPIQAWEG | DDIKTLGNVI | FMSQVVMQHG | ACEEKEERYF | LLFSSVLIML |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SASPRMSGFM | YQGKIPIAGM | VVNRLDEIEG | SDCMFEITGS | TVERIVVHCN | NNQDFQEWME |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QLNRLTKGPT | SCGSLSKTSS | SSCSTHSSFS | STGQPRGPLE | PPQIIKPWSL | SCLRPAPPLR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PSAALGYKER | MSYILKESSK | SPKTMKKFLH | KRKTERKASE | EEYVIRKSTA | ALEEDAQILK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VIEAYCTSAS | FQQGTRKDSV | PQVLLPEEEK | LIIEETRSNG | QTIIEEKSLV | DTVYALKDEV |
| 730 | 740 | 750 | 760 | 770 | |
| KELKQENKKM | KQCLEEELKS | RKDLEKLVRK | LLKQTDECIR | SESSSKTSIL | Q |