Q8K3W3

PR
Gene name
Casc3 (Mln51)
Protein name
Protein CASC3
Names
Cancer susceptibility candidate gene 3 protein homolog, Metastatic lymph node gene 51 protein homolog, MLN 51 homolog, Protein barentsz, Btz, mBtz
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:192160
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K3W3

Entry ID Method Resolution Chain Position Source
AF-Q8K3W3-F1 Predicted AlphaFoldDB

36 variants for Q8K3W3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs238376883 63 V>L No EVA
rs3389210403 100 E>K No EVA
rs3389161672 119 D>E No EVA
rs3389199062 125 A>E No EVA
rs3389161659 135 S>Y No EVA
rs3389186470 150 E>D No EVA
rs3389210470 153 E>K No EVA
rs3389133824 163 G>D No EVA
rs3389133759 169 D>V No EVA
rs3389161696 189 D>Y No EVA
rs3389161671 192 G>V No EVA
rs3402983702 207 K>IFP* No EVA
rs3389210411 218 D>G No EVA
rs3389210491 228 K>T No EVA
rs3389199089 253 R>Q No EVA
rs3389214924 287 N>K No EVA
rs3389202917 317 K>N No EVA
rs3389169578 340 L>R No EVA
rs3389203161 343 E>D No EVA
rs245461399 393 D>E No EVA
rs3389133849 410 K>E No EVA
rs256421968 450 V>I No EVA
rs3389200027 471 W>R No EVA
rs3389186484 472 S>N No EVA
rs27040992 474 S>G No EVA
rs3389133823 493 M>I No EVA
rs3389199100 503 R>Q No EVA
rs3389200409 503 R>W No EVA
rs3389214950 532 P>S No EVA
rs3389200072 533 V>A No EVA
rs3389169583 599 V>A No EVA
rs3389200403 651 A>T No EVA
rs214847108 653 P>S No EVA
rs3389173586 654 Q>* No EVA
rs3389200460 657 G>R No EVA
rs246160243 696 G>S No EVA

No associated diseases with Q8K3W3

No regional properties for Q8K3W3

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8K3W3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, perinuclear region
  • Nucleus
  • Nucleus speckle
  • Cytoplasm, Stress granule
  • Cytoplasm, Cytoplasmic ribonucleoprotein granule
  • Cell projection, dendrite
  • Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (PubMed:12843282)
  • Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
  • In nuclear speckles, colocalizes with MAGOH
  • Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (By similarity)
  • In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (Probable)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
U2-type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs.

4 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
identical protein binding Binding to an identical protein or proteins.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

6 GO annotations of biological process

Name Definition
intracellular mRNA localization Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADRRRQRAS QDTEDEESGA SGSDSGSPAR GGGSCSGSVG GGGSGSLPSQ RGGRGGGLHL
70 80 90 100 110 120
RRVESGGAKS AEESECESED GMEGDAVLSD YESAEDSEGE EDYSEEENSK VELKSEANDA
130 140 150 160 170 180
ADSSAKEKGE EKPESKGTVT GERQSGDGQE STEPVENKVG KKGPKHLDDD EDRKNPAYIP
190 200 210 220 230 240
RKGLFFEHDL RGQTQEEEVR PKGRQRKLWK DEGRWEHDKF REDEQAPKSR QELIALYGYD
250 260 270 280 290 300
IRSAHNPDDI KPRRIRKPRF GSSPQRDPNW IGDRSSKSHR HQGPGGNLPP RTFINRNTAG
310 320 330 340 350 360
TGRMSASRNY SRSGGFKDGR TSFRPVEVAG QHGGRSAETL KHEASYRSRR LEQTPVRDPS
370 380 390 400 410 420
PEPDAPLLGS PEKEEVASET PAAVPDITPP APDRPIEKKS YSRARRTRTK VGDAVKAAEE
430 440 450 460 470 480
VPPPSEGLAS TATVPETTPA AKTGNWEAPV DSTTGGLEQD VAQLNIAEQS WSPSQPSFLQ
490 500 510 520 530 540
PRELRGVPNH IHMGAGPPPQ FNRMEEMGVQ SGRAKRYSSQ RQRPVPEPPA PPVHISIMEG
550 560 570 580 590 600
HYYDPLQFQG PIYTHGDSPA PLPPQGMIVQ PEMHLPHPGL HPHQSPGPLP NPGLYPPPVS
610 620 630 640 650 660
MSPGQPPPQQ LLAPTYFSAP GVMNFGNPNY PYAPGALPPP PPPHLYPNTQ APPQVYGGVT
670 680 690
YYNPAQQQVQ PKPSPPRRTP QPVSIKPPPP EVVSRGSS