AiPD: Autoinhibited Protein Database

Gene name	Ssh3 (Ssh3l)
Protein name	Protein phosphatase Slingshot homolog 3
Names	SSH-like protein 3, SSH-3L, mSSH-3L
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:245857
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-117 (Predicted disordered autoinhibitory region) PR

1-117 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K330-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389525020	51	D>*	No	EVA
rs3389481232	52	G>*	No	EVA
rs3389515931	71	G>C	No	EVA
rs3389525051	72	E>Q	No	EVA
rs3389527526	80	T>I	No	EVA
rs3389516692	87	Q>H	No	EVA
rs3389519593	175	D>E	No	EVA
rs3389527472	224	A>P	No	EVA
rs3389424890	230	Q>H	No	EVA
rs3389507728	242	E>D	No	EVA
rs3389510821	250	E>G	No	EVA
rs3389509639	267	K>R	No	EVA
rs3389525071	271	A>E	No	EVA
rs3413061712	274	A>T	No	EVA
rs233289140	278	Q>R	No	EVA
rs3389473574	377	V>I	No	EVA
rs3389515898	393	H>Y	No	EVA
rs3389527474	397	E>V	No	EVA
rs3389424813	403	G>V	No	EVA
rs3389515854	421	V>I	No	EVA
rs3389481220	424	Y>F	No	EVA
rs3389507721	460	Y>*	No	EVA
rs3389464013	477	V>L	No	EVA
rs223697279	495	P>L	No	EVA
rs3389507733	506	E>G	No	EVA
rs3389525025	545	E>A	No	EVA
rs3389517183	566	L>F	No	EVA
rs3389424897	603	L>M	No	EVA
rs3408718559	604	V>L	No	EVA
rs216759300	621	S>R	No	EVA
rs3389527500	629	P>S	No	EVA

Type	Name	Position	InterPro Accession
domain	Dual specificity phosphatase, catalytic domain	333 - 461	IPR000340
domain	Tyrosine-specific protein phosphatases domain	390 - 445	IPR000387
domain	DEK, C-terminal	266 - 321	IPR014876
active_site	Protein-tyrosine phosphatase, active site	408 - 418	IPR016130
domain	Dual specificity protein phosphatase domain	325 - 466	IPR020422

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm, cytoskeleton Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
myosin phosphatase activity	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein tyrosine/serine/threonine phosphatase activity	Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
negative regulation of actin filament polymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8TE77	SSH3	Protein phosphatase Slingshot homolog 3	Homo sapiens (Human)	PR
Q5XIS1	Ssh3	Protein phosphatase Slingshot homolog 3	Rattus norvegicus (Rat)	PR