Q8K310
PR
Gene name |
Matr3 |
Protein name |
Matrin-3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17184 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q8K310
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1X4D | NMR | - | A | 390-478 | PDB |
| 1X4F | NMR | - | A | 478-576 | PDB |
| 7FBR | NMR | - | A | 390-478 | PDB |
| 7FBV | NMR | - | A | 478-576 | PDB |
| AF-Q8K310-F1 | Predicted | AlphaFoldDB |
37 variants for Q8K310
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1132787270 | 8 | S>T | No | EVA | |
| rs1134940209 | 9 | S>T | No | EVA | |
| rs1132059995 | 13 | D>V | No | EVA | |
| rs1134329482 | 14 | S>L | No | EVA | |
| rs3389473321 | 88 | N>T | No | EVA | |
| rs13475493 | 89 | I>M | No | EVA | |
| rs13475495 | 97 | L>W | No | EVA | |
| rs13475494 | 112 | L>W | No | EVA | |
| rs3408318621 | 122 | L>S | No | EVA | |
| rs3408418280 | 123 | D>V | No | EVA | |
| rs3408418284 | 124 | E>D | No | EVA | |
| rs3408352848 | 124 | E>Q | No | EVA | |
| rs3408418272 | 127 | R>L | No | EVA | |
| rs3389509325 | 155 | T>S | No | EVA | |
| rs3389502433 | 180 | E>K | No | EVA | |
| rs3389487703 | 195 | S>G | No | EVA | |
| rs3389509323 | 204 | H>N | No | EVA | |
| rs3389498429 | 248 | S>N | No | EVA | |
| rs3389442634 | 251 | E>D | No | EVA | |
| rs3389487714 | 272 | A>S | No | EVA | |
| rs3389509306 | 276 | S>R | No | EVA | |
| rs1132264544 | 359 | P>L | No | EVA | |
| rs3408589420 | 366 | G>PTAGPPR* | No | EVA | |
| rs3408352857 | 366 | G>PTAGPPR* | No | EVA | |
| rs3408352847 | 446 | D>M | No | EVA | |
| rs3389487061 | 543 | E>Q | No | EVA | |
| rs1133028246 | 548 | M>V | No | EVA | |
| rs31810788 | 624 | K>R | No | EVA | |
| rs1134863460 | 630 | S>A | No | EVA | |
| rs1133596136 | 634 | G>D | No | EVA | |
| rs31810784 | 742 | P>L | No | EVA | |
| rs217367340 | 771 | D>G | No | EVA | |
| rs236339133 | 776 | D>E | No | EVA | |
| rs256520889 | 780 | I>V | No | EVA | |
| rs3408589480 | 789 | V>LGIT* | No | EVA | |
| rs3406533367 | 834 | N>* | No | EVA | |
| rs1133160336 | 838 | E>* | No | EVA |
No associated diseases with Q8K310
7 regional properties for Q8K310
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 398 - 473 | IPR000504-1 |
| domain | RNA recognition motif domain | 496 - 571 | IPR000504-2 |
| domain | Matrin/U1-C, C2H2-type zinc finger | 800 - 831 | IPR000690 |
| domain | Matrin/U1-C-like, C2H2-type zinc finger | 288 - 322 | IPR003604-1 |
| domain | Matrin/U1-C-like, C2H2-type zinc finger | 797 - 832 | IPR003604-2 |
| domain | Matrin-3, RNA recognition motif 1 | 398 - 473 | IPR034928 |
| domain | Matrin-3, RNA recognition motif 2 | 496 - 575 | IPR034930 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| miRNA binding | Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of innate immune response | Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. |
| blastocyst formation | The initial formation of a blastocyst from a solid ball of cells known as a morula. |
| heart valve development | The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
| ventricular septum development | The progression of the ventricular septum over time from its formation to the mature structure. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43243 | MATR3 | Matrin-3 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKSFQQSSL | GRDSQGHGRD | LSAAGIGLLA | AATQSLSMPA | SLGRMNQGTA | RLASLMNLGM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSSLNQQGAH | SALSSASTSS | HNLQSIFNIG | SRGPLPLSSQ | HRGDTDQASN | ILASFGLSAR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLDELSRYPE | DKITPENLPQ | ILLQLKRRRT | EEGPTLSYGR | DGRSATREPP | YRVPRDDWEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRHFRRDSFD | DRGPSLNPVL | DYDHGSRSQE | SGYYDRMDYE | DDRLRDGERC | RDDSFFGETS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HNYHKFDSEY | ERMGRGPGPL | QERSLFEKKR | GAPPSSNIED | FHGLLPKGYP | HLCSICDLPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HSNKEWSQHI | NGASHSRRCQ | LLLEIYPEWN | PDNDTGHTMG | DPFMLQQSTN | PAPGILGPPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSFHLGGPAV | GPRGNLGAGN | GNLQGPRHMQ | KGRVETSRVV | HIMDFQRGKN | LRYQLLQLVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PFGVISNHLI | LNKINEAFIE | MATTEDAQAA | VDYYTTTPAL | VFGKPVRVHL | SQKYKRIKKP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EGKPDQKFDQ | KQELGRVIHL | SNLPHSGYSD | SAVLKLAEPY | GKIKNYILMR | MKSQAFIEME |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TREDAMAMVD | HCLKKALWFQ | GRCVKVDLSE | KYKKLVLRIP | NRGIDLLKKD | KSRKRSYSPD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GKESPSDKKS | KTDAQKTESP | AEGKEQEEKS | GEDGEKDTKD | DQTEQEPSML | LESEDELLVD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EEEAAALLES | GSSVGDETDL | ANLGDVSSDG | KKEPSDKAVK | KDPSASATSK | KKLKKVDKIE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ELDQENEAAL | ENGIKNEENT | EPGAESAENA | DDPNKDTSEN | ADGQNDENKE | DYTIPDEYRI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GPYQPNVPVG | IDYVIPKTGF | YCKLCSLFYT | NEEVAKNTHC | SSLPHYQKLK | KFLNKLAEER |
| RQKKET |