Q8K2A7
Gene name |
Ints10 |
Protein name |
Integrator complex subunit 10 |
Names |
Int10 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70885 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K2A7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K2A7-F1 | Predicted | AlphaFoldDB |
28 variants for Q8K2A7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs46040480 | 88 | R>T | No | EVA | |
| rs3388962252 | 94 | K>M | No | EVA | |
| rs3388989355 | 104 | E>* | No | EVA | |
| rs3388983973 | 138 | R>L | No | EVA | |
| rs3399271902 | 151 | G>A | No | EVA | |
| rs3399240086 | 151 | G>R | No | EVA | |
| rs3388983789 | 189 | R>P | No | EVA | |
| rs3388983846 | 223 | A>P | No | EVA | |
| rs211763929 | 236 | S>G | No | EVA | |
| rs3388986534 | 266 | V>I | No | EVA | |
| rs3399202893 | 267 | G>E | No | EVA | |
| rs49601394 | 304 | N>T | No | EVA | |
| rs246623707 | 343 | V>I | No | EVA | |
| rs49902410 | 346 | I>V | No | EVA | |
| rs3388986472 | 376 | R>I | No | EVA | |
| rs3388983809 | 411 | E>G | No | EVA | |
| rs3388983773 | 438 | L>M | No | EVA | |
| rs3398753719 | 552 | L>H | No | EVA | |
| rs3399240098 | 553 | L>V | No | EVA | |
| rs3399132062 | 586 | L>Q | No | EVA | |
| rs3399036737 | 587 | G>C | No | EVA | |
| rs3388984006 | 614 | Q>H | No | EVA | |
| rs3388990825 | 646 | I>N | No | EVA | |
| rs3399132075 | 654 | Q>R | No | EVA | |
| rs3388986481 | 686 | C>S | No | EVA | |
| rs3388979062 | 689 | N>K | No | EVA | |
| rs221747886 | 699 | I>T | No | EVA | |
| rs3388986550 | 707 | Q>E | No | EVA |
No associated diseases with Q8K2A7
No regional properties for Q8K2A7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8K2A7 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integrator complex | A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| snRNA processing | Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NVR2 | INTS10 | Integrator complex subunit 10 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAQGDCEFL | VQRARELVPQ | DLWAAKAWLI | TARSLYPADF | NIQYEMYTIE | RNAERTATAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLLYDMFVNF | PDQPVVWREI | SIITSALRND | SQDKQTQFLR | SLFETLPGRV | QCEMLLKVTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QCFNTLERSE | MLLLLLRRFP | ETVVQHGVGL | GEALLEAETI | EEQDSPVNCF | RKLFVCDVLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LIINNHDVRL | PANLLYKYLN | KAAEFYINYV | TRSTQSENQH | QGAQDTSDLM | SPSKRSSQKY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IIEGLTEKSS | HIVDPWERLF | KILNVVGMRC | EWQMDKGRRS | CSDLLHRMKE | LCRYMNSFDS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAHNNYKNQV | LYSTMLVFFK | SAFQYVSSIQ | PSLFQGPNAP | SQVPLILLED | VANVYGDVEI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DRSKHIHKKR | KLAEGREKTM | SSDDEECSAK | GRNRHIVVSK | ADLSNSIEVL | ESFKLARESW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELLYSLEFLD | KEFTRICLAW | KTDTWLWLRI | FLTDMIIYQG | QYKKAIASLH | HLAALQGSLS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPQITGQGTL | EHQRALIQLA | TCHFALGEYR | MTCEKVLDLM | CYMVLPIQDG | GKPQEEPSKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPKCRKGLDL | KLLPCTSKAI | MPYCLHLMLA | CFKLRAFTDS | RDDMALGHVI | VLLQQEWPRG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ENLFLKAISK | ICQQGNFQYE | NFFSYVTNID | MLEEFAYLRT | QEGGKIHLEL | LPNQGMLIKH |
| 670 | 680 | 690 | 700 | ||
| HTVTRGITKG | VKEDFRLAME | RQVSRCGENL | MAVLHRFCIN | EKILLLQTLT |