Q8K298
PR
Gene name |
Anln |
Protein name |
Anillin |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68743 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K298
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K298-F1 | Predicted | AlphaFoldDB |
69 variants for Q8K298
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389027890 | 6 | E>K | No | EVA | |
| rs225193183 | 55 | P>S | No | EVA | |
| rs3389030427 | 71 | R>L | No | EVA | |
| rs37932230 | 96 | S>F | No | EVA | |
| rs37157079 | 138 | T>A | No | EVA | |
| rs3389023494 | 187 | S>T | No | EVA | |
| rs38027729 | 271 | P>R | No | EVA | |
| rs265252769 | 297 | A>S | No | EVA | |
| rs37272738 | 299 | T>P | No | EVA | |
| rs258759247 | 303 | E>K | No | EVA | |
| rs242487726 | 307 | A>V | No | EVA | |
| rs223794682 | 317 | A>V | No | EVA | |
| rs260590324 | 325 | R>G | No | EVA | |
| rs237471318 | 325 | R>L | No | EVA | |
| rs3389032877 | 337 | A>P | No | EVA | |
| rs220725387 | 337 | A>V | No | EVA | |
| rs3399552323 | 350 | Q>L* | No | EVA | |
| rs3389019302 | 363 | R>* | No | EVA | |
| rs3389009706 | 380 | S>I | No | EVA | |
| rs243645917 | 388 | A>E | No | EVA | |
| rs3399883416 | 402 | I>F | No | EVA | |
| rs38133168 | 445 | A>T | No | EVA | |
| rs3389035768 | 453 | S>G | No | EVA | |
| rs3389029371 | 462 | V>L | No | EVA | |
| rs3389009657 | 477 | S>R | No | EVA | |
| rs37859091 | 478 | T>A | No | EVA | |
| rs3389004392 | 504 | S>F | No | EVA | |
| rs3389031740 | 513 | S>N | No | EVA | |
| rs3389027932 | 521 | L>V | No | EVA | |
| rs3388997792 | 543 | R>S | No | EVA | |
| rs3389027869 | 560 | I>N | No | EVA | |
| rs3389032911 | 571 | G>R | No | EVA | |
| rs3389027909 | 577 | K>R | No | EVA | |
| rs3389004389 | 599 | I>N | No | EVA | |
| rs3389035821 | 602 | M>L | No | EVA | |
| rs213152048 | 621 | I>S | No | EVA | |
| rs243729029 | 625 | P>L | No | EVA | |
| rs226708982 | 632 | N>S | No | EVA | |
| rs3389032935 | 637 | S>R | No | EVA | |
| rs3389035804 | 638 | P>A | No | EVA | |
| rs3389024084 | 648 | V>L | No | EVA | |
| rs3389027928 | 662 | R>L | No | EVA | |
| rs218585683 | 702 | K>N | No | EVA | |
| rs3389036956 | 733 | S>I | No | EVA | |
| rs3389027880 | 770 | D>Y | No | EVA | |
| rs3389036981 | 791 | Q>H | No | EVA | |
| rs219271054 | 795 | A>V | No | EVA | |
| rs36930798 | 844 | P>S | No | EVA | |
| rs3389032902 | 861 | T>S | No | EVA | |
| rs37518540 | 868 | V>D | No | EVA | |
| rs37770781 | 873 | E>D | No | EVA | |
| rs3389027844 | 883 | Q>* | No | EVA | |
| rs3389004356 | 890 | P>S | No | EVA | |
| rs3388997759 | 928 | L>F | No | EVA | |
| rs3389028049 | 932 | R>C | No | EVA | |
| rs3389035858 | 939 | V>L | No | EVA | |
| rs37547815 | 955 | A>G | No | EVA | |
| rs3389024054 | 959 | V>I | No | EVA | |
| rs37513608 | 966 | E>A | No | EVA | |
| rs3388997824 | 973 | I>K | No | EVA | |
| rs38554154 | 994 | S>G | No | EVA | |
| rs3389028077 | 996 | F>L | No | EVA | |
| rs3389024062 | 1012 | S>P | No | EVA | |
| rs3389036919 | 1013 | Y>* | No | EVA | |
| rs37952958 | 1013 | Y>S | No | EVA | |
| rs3388978823 | 1033 | N>T | No | EVA | |
| rs3389029388 | 1039 | I>K | No | EVA | |
| rs3389009667 | 1046 | F>L | No | EVA | |
| rs3389019264 | 1081 | K>* | No | EVA |
No associated diseases with Q8K298
5 regional properties for Q8K298
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pleckstrin homology domain | 980 - 1106 | IPR001849 |
| domain | Anillin homology domain | 797 - 950 | IPR012966 |
| domain | Anillin, N-terminal domain | 141 - 227 | IPR031970-1 |
| domain | Anillin, N-terminal domain | 424 - 480 | IPR031970-2 |
| domain | Anillin, PH domain | 981 - 1107 | IPR037840 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| actomyosin contractile ring | A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis. |
| bleb | A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| midbody | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| actomyosin contractile ring assembly | The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. |
| hematopoietic progenitor cell differentiation | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| podocyte cell migration | The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell. |
| positive regulation of bleb assembly | Any process that activates or increases the frequency, rate or extent of bleb assembly. |
| septin ring organization | Control of the formation, spatial distribution, and breakdown of the septin ring. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPFTEKLLE | RTRARRENLQ | RKMAERPTAV | ARSAPHAKRG | REPLSEASNQ | QQPLPGGEEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SCTKPSPSKK | RCSDKIEVGA | PDLENTEPID | VAKPCSPMPA | PRQAKPPAPA | AISESVAAPA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALLSADRGLN | SGSEASATSS | VKTRMQRLAE | QRRHWDSDLT | DDVSESSYFA | PVPTEDKAAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSKPPISNAS | ATPVGRRGRL | ANLAATICSW | EDDVSHSSAK | QNSVQEQPGT | ACLSKSSSAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GASASINSSS | VQQEATCCSP | RDGNASVRKD | PSSNAAHGPL | LSASVSSSVK | ASSPVTAATF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITENREAQNP | ELLHKTASPL | KTEARKPCEK | PTLSQGAQPK | EEANREVCLQ | SQSKDKLATP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGRGIKPFLE | RFGERCQEHS | KESPSYRASH | KTPNITPNTK | AIQERLFKQN | TCSSTTHLAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QLKQEREKEL | ACLRGRLDKG | NLWSAEKNEK | SRSKHLETKQ | EVHCQNTPLK | KHQTVASTPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TSVTDKVAEN | EPAVKLSSTE | PAGSTESEMT | KSSPLKITLF | LEEEKSLKVA | SDLEVEQNTE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AVREVEMSVD | DEDINSSRVI | NDIFSDVLEE | GELDVEKSQE | EMDQVGAENS | EEQEDALNIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SMSLLAPLAQ | TVGVVSLENV | ISSPPSELRD | SNLSAASPKP | GKFQRTRVPR | AESADSLGSE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DRDLLYSIDA | YRSQRFKETE | RPSIKQVIVR | KEDVTSKLGE | KKNVFSGQVN | IKQKMQELNN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DINLQQTVIY | QASQALNCCV | DEEHGKGSLE | EAEAERLLLI | ATEKRALLID | ELNKLKSEGP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QRRNKTSVIS | QSEFAPSKGS | VTLSEICLPL | KADFVCSTAQ | KTDASNYYYL | IMLKAGAEQM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VATPLASTAN | SLSGDALTFP | TTFTLHDVSN | DFEINIEVYS | LVQKKDSLGP | DKKKKASKSK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AITPKRLLTS | ITSKSSLHSS | VMASPGGLGA | VRTSNFTLVG | SHTLSLSSVG | DTKFALDKVP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FLSPLEGHIC | LKISCQVNSA | VEEKGFLTIF | EDVSGFGAWH | RRWCVLSGNC | ISYWTYPDDE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RRKNPIGRIN | LANCISHQIE | PANREFCARR | NTLELITVRP | QREDDRETLV | SQCRDTLCVT |
| 1090 | 1100 | 1110 | 1120 | ||
| KNWLSADTKE | ERDLWMQKLN | QVIVDIRLWQ | PDACYKPVGK | P |