Q8K1Y2

SS
Gene name
Prkd3 (Prkcn)
Protein name
Serine/threonine-protein kinase D3
Names
Protein kinase C nu type, nPKC-nu
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
mmu:75292
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) regulates axon degeneration, functioning as a key player in the cellular processes involved in neurodegenerative diseases and nerve injury. The physical interaction between the autoinhibitory Armadillo/HEAT motif (ARM) and catalytic Toll/interleukin-1 receptor (TIR) domains blocks the NAD hydrolase activity of SARM1. The autoinhibited TIR domain is activated upon axon injury, activating its NAD+ hydrolase activity and enabling TIR-dependent neuronal destruction.

Autoinhibitory domains (AIDs)

416-532 (PH domain) SS

Target domain

575-831 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

718-740 (Activation loop from InterPro)

Target domain

575-831 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8K1Y2

Entry ID Method Resolution Chain Position Source
AF-Q8K1Y2-F1 Predicted AlphaFoldDB

3 variants for Q8K1Y2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241386634 13 S>P No Ensembl
rs224432625 18 T>S No Ensembl
rs227209410 416 T>A No Ensembl

No associated diseases with Q8K1Y2

3 regional properties for Q8K1Y2

Type Name Position InterPro Accession
domain Toll/interleukin-1 receptor homology (TIR) domain 837 - 981 IPR000157
domain Sterile alpha motif domain 687 - 754 IPR001660-1
domain Sterile alpha motif domain 757 - 826 IPR001660-2

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Cytoplasm
  • Cell projection, axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

1 GO annotations of biological process

Name Definition
protein kinase D signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15139 PRKD1 Serine/threonine-protein kinase D1 Homo sapiens (Human) EV
Q9BZL6 PRKD2 Serine/threonine-protein kinase D2 Homo sapiens (Human) SS
O94806 PRKD3 Serine/threonine-protein kinase D3 Homo sapiens (Human) SS
Q62101 Prkd1 Serine/threonine-protein kinase D1 Mus musculus (Mouse) SS
Q8BZ03 Prkd2 Serine/threonine-protein kinase D2 Mus musculus (Mouse) SS
Q5XIS9 Prkd2 Serine/threonine-protein kinase D2 Rattus norvegicus (Rat) SS
Q9WTQ1 Prkd1 Serine/threonine-protein kinase D1 Rattus norvegicus (Rat) SS
O45818 dkf-2 Serine/threonine-protein kinase dkf-2 Caenorhabditis elegans SS
10 20 30 40 50 60
MKAAEIKRDL TNIQKSMSEI NDLAKERITG GPGSISTTSA SAITAPSTMS QTTTSRLAPK
70 80 90 100 110 120
LTSAHPSIDD LRGLSRQDKI TQLQKKIRAS FENLVDHDDS NVIVTLPDDD DCPHNHFGSG
130 140 150 160 170 180
LNLTHPTAAQ LSASGLSGSS KTIDTIKFQE KSMKTESKTK VVTDGFSSEQ ATSNSAEMKR
190 200 210 220 230 240
LQAGDIDYQE SKGASAMRNR LEVDGVKTEE NAAVIKEALS LRTGDITQQA SNNVAASSIT
250 260 270 280 290 300
VQSENFSADK KAISQSQQSQ TMTSNGIISQ EKHVSSASQA NYSMSHKGVS STGSSMITSS
310 320 330 340 350 360
SQMSAMNGQM LKLADLKLDD LKSLTAGSGQ QEIEQTINKY SNMLTSIVSS LQEDERGGSA
370 380 390 400 410 420
ITVHDVGGKK SQYLEKINEV IRRAWAVPTH GHELGYSLCN SLRQSGGLDL LMKNCVKPDL
430 440 450 460 470 480
QFSSAQLLEQ CLTTENRKHV VDNGLDKVVN VACVCTKNSN MEHSRVGTGI LEHLFKHSEG
490 500 510 520 530 540
TCSDVIRLGG LDAVLFECRT SDLETLRHCA SALANLSLYG GAENQEEMIL RKVPMWLFPL
550 560 570 580 590 600
AFHNDDNIKY YACLAIAVLV ANKEIEAEVL KSGCLDLVEP FVTSHDPSAF ARSNLAHAHG
610 620 630 640 650 660
QSKHWLKRLV PVLSSNREEA RNLAAFHFCM EAGIKREQGN TDIFREINAI EALKNVASCP
670 680 690 700 710 720
NAIASKFAAQ ALRLIGETVP HKLSQQVPLW SVEDVQEWVK QIGFNDYIDK FNESQVDGDL
730 740 750 760 770 780
LLKLNQDNLR ADIGIGNGIL LKRFERELQN LKRMADYSSK DTAKMHQFLS EIGTDYCTYT
790 800 810 820 830 840
YAMLNAGIDK CALPHVNEDM LMTECGIHNS IHRLRILNAV KNLENSLPSS SEENMAKTLD
850 860 870 880 890 900
VFVSYRRSNG SQLASLLKVH LQLRGFSVFI DVERLEAGKF DNGLLNSIRQ AKNFVLVLTP
910 920 930 940 950 960
DALHRCINDE DCKDWVHREI VAALNSNCNI IPIIDQQFDW PEVERLPEDM RSVAHFNGVN
970 980 990 1000 1010 1020
WIHDYQDACI DKLERFLRGE KNIDRIAAMV PGTPGSVSYQ RMHSNDSDYQ SGGAGAGSGA
1030 1040 1050 1060 1070 1080
GTGGGGGGGV TGSVVDGLMV AANGSGQANH QANRYRQSPS PARQRGSTSQ LSGYSRAPSK
1090 1100 1110 1120 1130 1140
RSQILTPYRT QQAALLHKTG AGSASMQNMM PLAYLPPRRS SAAGLGHGSG SGMGSGYRSH
1150 1160 1170 1180 1190 1200
SVDGLLDQAG STPEQRIAAA AAKVTAGSTA LTNASSTSTL QPEEEVTDAA LNDSVTRRDK
1210 1220 1230 1240 1250 1260
HTLSPPGNVQ QHRKSRSLDH ILSKQTLAEL LPPSSELADG TQSMQNLAIP MTPQPQRRDT
1270 1280 1290 1300 1310 1320
SSSSKSPTPE RPPQPAMERV RERQSPEGVS ATESEREDQP EECLRHGNQQ RASASVHRGA
1330 1340 1350
SLTSNKTSNS SLGSNFSAGG NNKTIFNRTM KKVRSLIKKP