Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8K1S1

Entry ID Method Resolution Chain Position Source
AF-Q8K1S1-F1 Predicted AlphaFoldDB

30 variants for Q8K1S1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs230850557 30 H>R No EVA
rs3388904578 32 S>P No EVA
rs3388893276 110 N>K No EVA
rs3388893234 160 F>I No EVA
rs3388902731 163 D>V No EVA
rs3388879080 174 P>S No EVA
rs3388896094 187 G>R No EVA
rs3388879111 188 P>S No EVA
rs3388891420 196 L>Q No EVA
rs32208677 208 A>T No EVA
rs255224041 244 R>L No EVA
rs3388882499 250 W>* No EVA
rs3388897353 255 Q>E No EVA
rs3388891329 256 R>S No EVA
rs3388896096 307 Q>H No EVA
rs3388858506 311 P>S No EVA
rs47279719 320 A>V No EVA
rs3388858456 343 T>K No EVA
rs31650947 350 P>L No EVA
rs3388858490 357 S>I No EVA
rs3388900079 359 H>Q No EVA
rs3388879069 377 H>Y No EVA
rs3388891471 379 L>P No EVA
rs3388882483 392 W>C No EVA
rs3388896049 395 G>S No EVA
rs3388904614 444 L>V No EVA
rs3388899522 455 V>D No EVA
rs3388858504 480 R>H No EVA
rs31573735 531 H>Y No EVA
rs264798503 532 E>K No EVA

1 associated diseases with Q8K1S1

Without disease ID

13 regional properties for Q8K1S1

Type Name Position InterPro Accession
domain Cysteine-rich flanking region, C-terminal 158 - 207 IPR000483
repeat Leucine-rich repeat 101 - 159 IPR001611
repeat Leucine-rich repeat, typical subtype 75 - 98 IPR003591-1
repeat Leucine-rich repeat, typical subtype 99 - 122 IPR003591-2
repeat Leucine-rich repeat, typical subtype 123 - 146 IPR003591-3
repeat Leucine-rich glioma-inactivated, EPTP repeat 396 - 438 IPR005492
repeat EAR 210 - 252 IPR009039-1
repeat EAR 256 - 298 IPR009039-2
repeat EAR 302 - 349 IPR009039-3
repeat EAR 351 - 394 IPR009039-4
repeat EAR 396 - 439 IPR009039-5
repeat EAR 441 - 483 IPR009039-6
repeat EAR 487 - 532 IPR009039-7

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

9 GO annotations of biological process

Name Definition
adult locomotory behavior Locomotory behavior in a fully developed and mature organism.
glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.
gliogenesis The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
myelination in peripheral nervous system The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
neuron maturation A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
Schwann cell development The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGGAGILLFL LAWAGAGVAW SPPKGKCPPH CSCSKENTLC EGSPELPESF STTLLSLSLV
70 80 90 100 110 120
RMGVSRLKAG SFLKMPSLHL LLFTSNTFSV IEGDAFIGLS YLQYLFIEDN KIGSISKNAL
130 140 150 160 170 180
RGLRSLTHLS LANNHLEALP RFLFRGLETL THVDLRGNPF QCDCRVLWLL QWMPTVNASV
190 200 210 220 230 240
GTGACAGPPA VAQIQLNHLD PKKFKCRATE LSWLQTVGES ALSVESFSYQ GEPHMVLAQP
250 260 270 280 290 300
FAGRCLILVW DYSLQRFRPE EELSAPSVVS CKPLVLGPRL FILAARLWGG SQLWSRSSPD
310 320 330 340 350 360
LRLTPVQVLA PQRLLRPNDA ELLWLDGQPC FVVADASKAG STTLLCRDGP GFYPRQSLHA
370 380 390 400 410 420
WHRDTDAEAL ELDGRPHLLL ASASQRPVLF HWVGGRFERR TDIPEAEDVY ATKHFQAGGD
430 440 450 460 470 480
VFLCLTRYIG DSMVMRWDGS MFRLLQQLPS RGSHVFQPLL IARDQLAILG SDFAFSQVFR
490 500 510 520 530
FESDKGILEP LQELGPPALV APRAFAQVTV AGRRFLFAAC FKGPTQIYQH HELDLSA