Q8JZY4
Gene name |
Prorp (Kiaa0391, Mrpp3) |
Protein name |
Mitochondrial ribonuclease P catalytic subunit |
Names |
Mitochondrial ribonuclease P protein 3, Mitochondrial RNase P protein 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66132 |
EC number |
3.1.26.5: Endoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8JZY4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8JZY4-F1 | Predicted | AlphaFoldDB |
33 variants for Q8JZY4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389200594 | 7 | G>V | No | EVA | |
| rs3389225914 | 11 | I>V | No | EVA | |
| rs585929988 | 36 | A>V | No | EVA | |
| rs580047539 | 43 | W>R | No | EVA | |
| rs215185403 | 50 | T>I | No | EVA | |
| rs3389207967 | 57 | L>H | No | EVA | |
| rs3389200596 | 63 | K>N | No | EVA | |
| rs3389238824 | 68 | R>G | No | EVA | |
| rs51785818 | 76 | Q>P | No | EVA | |
| rs3389242030 | 93 | S>T | No | EVA | |
| rs3389225939 | 97 | A>V | No | EVA | |
| rs3389200582 | 123 | E>* | No | EVA | |
| rs3389236551 | 175 | L>V | No | EVA | |
| rs579599758 | 219 | H>D | No | EVA | |
| rs3389243540 | 256 | D>E | No | EVA | |
| rs3389200588 | 256 | D>N | No | EVA | |
| rs583009248 | 262 | N>S | No | EVA | |
| rs3389247503 | 271 | N>K | No | EVA | |
| rs3389238199 | 272 | L>F | No | EVA | |
| rs3389207995 | 284 | D>N | No | EVA | |
| rs3389249731 | 284 | D>V | No | EVA | |
| rs224187111 | 297 | K>I | No | EVA | |
| rs580907809 | 304 | Y>* | No | EVA | |
| rs3389207994 | 322 | T>P | No | EVA | |
| rs3389238888 | 408 | L>I | No | EVA | |
| rs3389233521 | 418 | R>C | No | EVA | |
| rs3389225950 | 512 | R>C | No | EVA | |
| rs3389212816 | 515 | F>S | No | EVA | |
| rs3389172969 | 569 | V>L | No | EVA | |
| rs247364233 | 582 | D>A | No | EVA | |
| rs864298021 | 582 | D>N | No | EVA | |
| rs3389200599 | 584 | C>S | No | EVA | |
| rs3389247512 | 585 | C>S | No | EVA |
No associated diseases with Q8JZY4
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.26.5 | Endoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrial ribonuclease P complex | A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| ribonuclease P activity | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial tRNA 5'-end processing | The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. |
| tRNA 5'-leader removal | Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O15091 | PRORP | Mitochondrial ribonuclease P catalytic subunit | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTFYLSGFRS | IPKLWKSNPY | FELGPATSST | PFFLCAIGNQ | QRWFSVKPTT | PPNSKALNLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTKARTHRKG | NDNNGQVSSD | PHYFAAGAAK | KRSHIGANPQ | NQGHALPVRS | SVQLPTKPLN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SAEWDKLKED | FKGKASFEDF | IISQMARNCC | SVDVAKSLLA | WVAAKNNGIV | GYNLLVKYLY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LCVFHKQTSE | VIDVYEIMKA | KYKSLESGGY | TLLIRGLIHS | DRWRESLLLL | EDIKKVMVPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKNYGDCIQG | ALLHQDVNTA | WNLYQELIGH | NLIPPLETLK | AFFDYGKDIN | DDHYSDKLLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ILLYLRNNQL | YPGESFAHSI | KTWFESIPGR | QWKGQFTTIQ | KSGQCSGCGR | TIEPIHLSPE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EYEFLKEKIM | RDVIDGGDQY | KKTTPQELKR | FESFVNSCPP | FDIVIDGLNV | AKMFPKGRES |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QNLLGVVSQL | AQQNLQLLVL | GRKHMLRPSS | QWRKEEMEQV | RKQAHCFFAD | NISEDDPFLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YATLNSGNHC | KFITKDLLRD | HKACLPDART | QRLFFKWQQG | HQLAIMKGFQ | KSKLTFQHIL |
| 550 | 560 | 570 | 580 | ||
| SYDTVVQRTG | DSWHIPYDED | LVQRSSCEVP | TKWLCLQRKT | PDPC |