Q8JZX9

PR
Gene name
Cdc42ep2 (Borg1, Cep2)
Protein name
Cdc42 effector protein 2
Names
Binder of Rho GTPases 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:104252
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-176 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JZX9

Entry ID Method Resolution Chain Position Source
AF-Q8JZX9-F1 Predicted AlphaFoldDB

11 variants for Q8JZX9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389518897 31 S>I No EVA
rs3389486623 59 Q>* No EVA
rs3389519924 64 L>F No EVA
rs3389512915 84 Q>* No EVA
rs3389511996 92 C>Y No EVA
rs3389511975 121 L>M No EVA
rs3389529066 135 L>F No EVA
rs3407824832 143 Q>H No EVA
rs3389512006 161 G>D No EVA
rs217693899 172 E>D No EVA
rs37244441 205 H>Q No EVA

No associated diseases with Q8JZX9

1 regional properties for Q8JZX9

Type Name Position InterPro Accession
domain CRIB domain 29 - 85 IPR000095

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system ; Peripheral membrane protein
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
opioid peptide activity Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.
small GTPase binding Binding to a small monomeric GTPase.

6 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cellular response to interferon-gamma Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of pseudopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.
regulation of cell shape Any process that modulates the surface configuration of a cell.
Rho protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGDD MFGDISFLQG
70 80 90 100 110 120
KFHLLPGTAV EEAEEDGSFD LPFQFTRTTT VCGRELPDGL SPLLKNAISL PVIGGPQALT
130 140 150 160 170 180
LPTAQAPPKP PRLHLESPQP SPQPSPQGAG NVDVWRIPEA GSPHNGMSPE PEAEEPFLSH
190 200 210
ASSLLSLHVD LGPSILDDVL QIMDHDLGRV QIPT