Q8JI28

PR
Gene name
tll1 (xlr)
Protein name
Tolloid-like protein 1
Names
Metalloprotease xolloid-like, Xenopus tolloid-like protein 1, Xlr
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399178
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JI28

Entry ID Method Resolution Chain Position Source
AF-Q8JI28-F1 Predicted AlphaFoldDB

No variants for Q8JI28

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8JI28

No associated diseases with Q8JI28

16 regional properties for Q8JI28

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 585 - 596 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 740 - 751 IPR000152-2
domain EGF-like domain 569 - 610 IPR000742-1
domain EGF-like domain 725 - 765 IPR000742-2
domain CUB domain 344 - 456 IPR000859-1
domain CUB domain 457 - 569 IPR000859-2
domain CUB domain 613 - 725 IPR000859-3
domain CUB domain 769 - 881 IPR000859-4
domain CUB domain 882 - 998 IPR000859-5
domain Peptidase M12A 143 - 342 IPR001506
domain EGF-like calcium-binding domain 569 - 610 IPR001881-1
domain EGF-like calcium-binding domain 725 - 765 IPR001881-2
domain Peptidase, metallopeptidase 148 - 290 IPR006026
conserved_site EGF-like calcium-binding, conserved site 569 - 594 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 725 - 749 IPR018097-2
domain Tolloid/BMP1 peptidase domain 143 - 342 IPR034036

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNMPSWLIFL LTGWTFCGNF FACGGLDYDY PNYENEEEKN EAIDYKDPCK AVVFWGDIAL
70 80 90 100 110 120
DEEDLKMFHI DRTIDLTQHS NEKLGHTTGG LEEHDLSKKR GALYQLIERI RRFGSGQENT
130 140 150 160 170 180
TANSQKVDNN QSGKSKKIRI PRAATSRTER IWPGGVIPYV IGGNFTGSQR AMFKQAMRHW
190 200 210 220 230 240
EKHTCVTFIE RTDEESYIVF TYRPCGCCSY VGRRGNGPQA ISIGKNCDKF GIVVHELGHV
250 260 270 280 290 300
IGFWHEHTRP DRDDHVTIIR ENIQPGQEYN FLKMEPGEVH SLGESYDFDS IMHYARNTFS
310 320 330 340 350 360
RGMFLDTILP SRDENGLRPP IGQRTRLSKG DIAQARKLYR CPACGETLQE STGNFSSPGF
370 380 390 400 410 420
PNGYPSYTHC IWRISVTPGE KIVLNFTTMD LYKSSLCWYD YIEVRDGYWK KSPLLGRFCG
430 440 450 460 470 480
DKLPDVLTST DSRMWIEFRS SSNWVGKGFA AVYEAICGGE IHKDAGQIQS PNYPDDYRPL
490 500 510 520 530 540
KECVWKITVA ENYNVGLTFQ AFEIERHDNC AYDYLEVRDG SSENSPLIGH FCGYDKPEDI
550 560 570 580 590 600
RSTSNTLWMK FVSDGTVNKA GFAANFLKEE DECARPDNGG CEQRCVNTLG SYKCSCDPGY
610 620 630 640 650 660
ELAPDKKSCE AACGGLLTKL NGTITTPAWP KEYPPNKNCV WQVVAPSQYR ISMKFDYFEL
670 680 690 700 710 720
EGNEVCKYDY VEVRSGLSSD SKLHGKFCGT EVPEVITSQF NNMRIEFKSD NTVSKKGFRA
730 740 750 760 770 780
HFFSDKDECS KDNGGCQHEC INTIGSYVCQ CRNGFVLHDN KHDCKEAECE HRIHSSNGVI
790 800 810 820 830 840
TSPNWPDKYP SRKECTWEIS ATPGHRVKLS FSEFEIEQHQ ECAYDHLEVF DGETEKSSIL
850 860 870 880 890 900
GRLCGSKVPE PLVATGNEMF IRFVSDASVQ RKGFQATHST ECGGRLKAEA KPRDLFSHAQ
910 920 930 940 950 960
FGDNNYPVQA DCEWILMTER GLRIELNFQT FEVEEEADCG YDFMELFDGH DASAMRLGRF
970 980 990 1000
CGSGPPEEIV STGDAVLIHF HTDDTISKKG FHIRYRSVKY QDILHTK