Q8J0Q0

PR
Gene name
MNS1
Protein name
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Names
Crh-like protein 1, Man(9)-alpha-mannosidase
Species
Candida albicans (Yeast)
KEGG Pathway
EC number
3.2.1.113: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8J0Q0

Entry ID Method Resolution Chain Position Source
AF-Q8J0Q0-F1 Predicted AlphaFoldDB

No variants for Q8J0Q0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8J0Q0

No associated diseases with Q8J0Q0

1 regional properties for Q8J0Q0

Type Name Position InterPro Accession
domain Myc-type, basic helix-loop-helix (bHLH) domain 129 - 193 IPR011598

Functions

Description
EC Number 3.2.1.113 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide.

3 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLLKGFMLSL VLYAVYHLAS NGGQFMFDFS GQSKWERAQS EVRQAILDSW HTYEKYGWGY
70 80 90 100 110 120
DVYHPIKQEG ENMGPKPLGW MIVDSLDTLM IMDCPEEVSR ARDWIKNDLD YTFDYNVNTF
130 140 150 160 170 180
ETTIRMLGGL LSAYHFSNDD VYLDKAVQLA NALHGAYDSP SGIPYSSVNL KSGKGIKNHV
190 200 210 220 230 240
DNGASSTAEA ATVQLEMKYL SKLTGEILWW NLAEKVMQVL ESNKPQDGLV PIYVNPDTGK
250 260 270 280 290 300
YQGHLIRLGS RGDSYYEYLL KQYLQTNKQE LVYWDMYRES VEGVKKHLVS DSYPSGLTFI
310 320 330 340 350 360
GELDNGIGGK LSTKMDHLVC FYGGLLALGA TGGLTLNEAQ SLKSWNEERE ADFKLGEELT
370 380 390 400 410 420
YTCYKMYHDV SPTGLSPEIV VFNEDTSKSK DFIIKPLDRH NLQRPETVES LFYLYRLTGD
430 440 450 460 470 480
VKYREMGYEI FQNFIKYTKV VNSEGEVSFS SLSDVTSFDS NGLPKFKDNT ESFWWAETLK
490 500 510 520 530 540
YLYLLFDDTN KIPLTDYVFN TEAHPFPRFD TNDYFKTGWR RKIDENEKAQ MRESKVIDKS
550 560
NLPEAQPVDK SADQEAKEII EEIAG