Q8J093
Gene name |
PMI40 (HPODL_00814) |
Protein name |
Mannose-6-phosphate isomerase |
Names |
Phosphohexomutase, Phosphomannose isomerase, PMI |
Species |
Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1) (Yeast) (Hansenula polymorpha) |
KEGG Pathway |
|
EC number |
5.3.1.8: Interconverting aldoses and ketoses |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8J093
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8J093-F1 | Predicted | AlphaFoldDB |
No variants for Q8J093
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8J093 | |||||
No associated diseases with Q8J093
5 regional properties for Q8J093
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Phosphomannose isomerase, type I, conserved site | 131 - 139 | IPR018050-1 |
| conserved_site | Phosphomannose isomerase, type I, conserved site | 277 - 302 | IPR018050-2 |
| domain | Phosphomannose isomerase type I, C-terminal domain | 341 - 385 | IPR046456 |
| domain | Phosphomannose isomerase type I, catalytic domain | 7 - 156 | IPR046457 |
| domain | Phosphomannose isomerase type I, helical insertion domain | 178 - 258 | IPR046458 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.3.1.8 | Interconverting aldoses and ketoses |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose-6-phosphate isomerase activity | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| GDP-mannose biosynthetic process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSAPKLFRV | IGGAQNYDWG | KLGSTSAVAR | FAKLNDPENV | SIEEEKPYAE | LWMGTHPSVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVSAQDRTPL | RDLVRAAPEE | MLGQDIIDKF | GSKEGIPFLF | KVLSIRKVLS | IQAHPDKALA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RQLHASDPKH | YPDDNHKPEM | AVAITDFEAF | CGFKPLAEID | ALLQKIPEFR | ELVGDDVVAE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FHSGIDSSDV | AGKKKLLQKV | FSRVMNSPES | KFEPLAARLV | ERTKSDPQLF | GETLADLIQR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDAQFPNDIG | LFCGCLLLNH | CILKSGEAMF | LEAKDPHAYI | SGDIMECMAA | SDNVIRAGFT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PKFKDVEVLV | DCLTYSFNPV | EEQKLKPAPF | PRGTGVAELK | LYDPPIDEFS | VLQTTFTSAG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEKFEGLDGP | SLLIVTEGKG | KIKLQGSDEA | LDASTGNIFF | VAPKAAIELV | SESKDTFTSY |
| RAFCEA |